Okamoto Shigefumi

オカモトシゲフミ | Okamoto Shigefumi

Affiliation and department：
Job title： Professor

Research field (4)： Bacteriology , Virology , Oral medicine , Basic nursing

Research keywords (5)： Enterococcus , Streptococcus , microbiome , superinfection , インフルエンザウイルス

Research theme for competitive and other funds (33)：

2023 - 2027 Exosomes derived from intestinal bacteria in bronchial asthma induced by environmental chemicals and their prevention methods
2023 - 2027 Establishment of diabetic foot ulcer management using the diabetic foot ulcer healing process monitoring scale
2023 - 2026 頭頸部がん患者の重症放射線皮膚炎の評価指標と関連するスキンパラメーターの同定
2022 - 2026 Development of preventive methods for age-related diseases based on the elucidation of the relationship between oral frailty and intestinal bacterial frailty
2023 - 2025 Analysis of the association between polyamine production in the scalp bacterial flora and hair growth.

2022 - 2025 Development of a framework for improving lifestyle-related diseases targeting the mutual network of gut microbiota

2021 - 2025 The onset mechanism of cellulitis caused by streptococci secondary to lymphedema and its preventive and palliative care measures

2021 - 2025 Pathogenic mechanism of cellulitis caused by Streptococcus secondary to lymphedema and its its preventive / palliative care measures

2021 - 2025 糖代謝異常者への個別食事箋の提案を可能とする食後高血糖制御アルゴリズムの開発

2020 - 2024 Development of an noninvasive liquid assessment technologies for smart home-care

2020 - 2023 ASSOCIATION BETWEEN FRAGIL SKIN ENVIRONMENT AND PRESSURE INJURY RECURRENCE AFTER WOUND CLOSURE FOR ADVANCED CARE DEVELOPMENT

2019 - 2023 Relationship between microbiota changes on the epithelium and onset of epithelial infectious diseases caused by HIV infection, and application to palliative care against the diseases

2017 - 2021 Investigation for the cause of postpressure sores infections focusing on the change in skin resident flora, and study on preventive and palliative care based on the results for this investigation

2016 - 2020 Molecular epidemiological analysis of Streptococcus pneumoniae in Southeast Asian countries

2017 - 2020 インフルエンザウイルス感染に続発する細菌性肺炎の重症化に寄与する宿主・細菌因子群の探索と新規感染制御法の開発

2016 - 2018 先端的日和見感染症研究プロジェクト

2014 - 2017 Mechanism of invasive diseases by superinfection with influenza virus and oral Streptococcus

2015 - 2016 インフルエンザウイルスとの並行感染により重症肺炎を発症するレンサ球菌群の同定とその発症に関与する細菌側の病原因子の解析

2012 - 2015 Amino acid mutations associated with growth ability of avian influenza viruses

2011 - 2014 粘膜免疫により産生される粘膜分泌型抗インフルエンザ抗体の交叉防御機構の解析

2009 - 2012 将来出現が予想される新型インフルエンザに即応できる次世代ワクチンの臨床応用に向けた研究

2009 - 2010 インフルエンザ感染による肺炎レンサ球菌の組織侵入増強に関わる分子群同定とその機能

2008 - 2010 Identification and functional analysis of factors related to human herpesvirus pathogenesis

2009 - 2009 口腔レンサ球菌による新しい肺炎発症モデルの確立とその発症機序の解明

2006 - 2007 Pathogenic mechanism of severe pneumonia caused by superinfection with influenza virus and oral bacteria

2006 - 2007 Protective immunity against group Astreptococcus infection following immunization with fibronectin-binding proteins

2004 - 2005 Molecular mimic of group A streptococcal surface proteins

2004 - 2005 Induction of inflammatory immune response by streptococcal water-insoluble α-glucans and association with periodontal diseases

2002 - 2004 Molecular analysis of streptococcal infections diseases by the functional genomics.

2002 - 2003 Characterization of surface proteins on cell invasion of streptococcus pyogenes

2002 - 2003 インフルエンザウイルスとの混合感染で発症する劇症型A群レンサ球菌感染症の病因解析

2000 - 2001 Induction of mucosal immune responses by DNA vaccine encoding Porphyromonas gingivalis fimbriae

2000 - 2001 劇症型GAS感染症と好中球,筋細胞表面ADPリボシル転移酵素活性との因果関係

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Papers (97)：

Masaki Karino, Masashi Yanagihara, Tetsuya Harada, Megumi Sugo, Mizuki Karino, Hirofumi Ohtaki, Hiroyuki Hanada, Toru Takano, Masaya Yamato, Shigefumi Okamoto. New multilocus sequence typing scheme for Enterococcus faecium reveals sequential outbreaks of vancomycin-resistant E. faecium ST1162 and ST610 in a Japanese tertiary medical center. Microbiology Spectrum. 2024
Nao Miyamae, Kazuhiro Ogai, Mao Kunimitsu, Masayuki Fujiwara, Makoto Nagai, Shigefumi Okamoto, Mayumi Okuwa, Makoto Oe. Frequency of ischemic cardiac events in patients receiving long-term multikinase inhibitor: A report of three cases. Asia-Pacific Journal of Oncology Nursing. 2024. 12. 100624-100624
Yuna Miyajima, Shigehiro Karashima, Ren Mizoguchi, Masaki Kawakami, Kohei Ogura, Kazuhiro Ogai, Aoi Koshida, Yasuo Ikagawa, Yuta Ami, Qiunan Zhu, et al. Prediction and causal inference of hyperuricemia using gut microbiota. Scientific reports. 2024. 14. 1. 9901-9901
Fumihiko Suzuki, Shigefumi Okamoto, Shingo Nakai, Sakae Miyagi, Hiromasa Tsujiguchi, Akinori Hara, Thao Thi Thu Nguyen, Yukari Shimizu, Koichiro Hayashi, Keita Suzuki, et al. Association between animal protein intake, oral frailty and calf circumference in middle-aged and older adults: a cross-sectional analysis from the Shika study. BMJ open. 2024. 14. 2. e078129
Kazuhiro Ogai, Benderli Christine Nana, Yukie Michelle Lloyd, John Paul Arios, Boonyanudh Jiyarom, Honore Awanakam, Livo Forgu Esemu, Aki Hori, Ayaka Matsuoka, Firzan Nainu, et al. Skin microbiome profile in people living with HIV/AIDS in Cameroon. Frontiers in Cellular and Infection Microbiology. 2023. 13. 1211899

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MISC (30)：

鈴木史彦, 岡本成史, 宮城栄重, 辻口博聖, 原章規, NGUYEN Thao Thi Thu, 清水由加里, 林宏一郎, 鈴木啓太, 仲井慎吾, et al. オーラルフレイルによるミネラル摂取量の減少と骨密度の関係:志賀町研究から. 日本予防医学会学術総会プログラム・抄録集. 2021. 18th (CD-ROM)
岡本成史. ココナッツオイル中に含有する中鎖脂肪酸の抗菌作用について. 食と健康. 2020. 13. 88-98
岡本成史. 寝たきり高齢者における皮膚常在細菌叢の特徴と褥瘡後感染症発症ととの関連性-マイクロバイオーム解析からみえたこと-. 地域ケアリング. 2019. 21. 11. 93-98
長谷剛志, 小山岳海, 大矢明日香, 本保敦志, 川尻秀一, 岡本成史. 高齢入院患者における誤嚥性肺炎発症に関連する口腔因子ならびに認知症の有無・種別と年齢による同因子の変化. 日本口腔科学会雑誌. 2019. 68. 2. 160-160
岡本成史, 大貝和裕, 須釜淳子. 福祉の現場から寝たきり高齢者における皮膚常在細菌叢構成の変化. 地域ケアリング. 2018. 20. 1. 60-66

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Books (6)：

進化する皮膚科学機能研究・臨床・評価・製品開発の最前線
エヌ・ティー・エス 2021
ヒト常在菌叢と生理機能・全身疾患
シーエムシー出版 2020 ISBN:9784781315195
ワクチンー基礎から臨床までー
朝倉書店 2018 ISBN:9784254301151
メディカルサイエンス微生物学検査学<第二版>
近代出版 2016 ISBN:9784874022283
Interface Oral Health Science 2007-Water-insoluble α-glucans from Streptococcus sobrinus induce inflammatory immune responses.
Springer Japan 2007

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Education (2)：

1991 - 1995 Tohoku University Graduate School of Dentistry Department of Clinical Dentistry
1985 - 1991 Tohoku University School of Dentistry Department of Dentistry

Professional career (1)：

Ph.D. (Dental Science) (Tohoku University)

Work history (8)：

2023/04 - 現在 Osaka University Graduate School of Medicine Division of Health Sciences Professor
2021/04 - 2023/03 Kanazawa University Institute for Frontier Science Initiative Professor
2014/04 - 2021/03 Kanazawa University Graduate School of Medical Health Sciences Professor
2006/04 - 2014/03 医薬基盤研究所研究員
2004/07 - 2006/03 Fukuoka Dental College

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Association Membership(s) (7)：

日本臨床微生物学会 , 日本創傷治癒学会 , 臨床検査教育学会 , JAPANESE SOCIETY FOR INFECTION PREVENTION AND CONTROL , THE JAPANESE ASSOCIATION FOR INFECTIOUS DISEASES , 日本細菌学会 , American Society for Microbiology

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