Rchr

J-GLOBAL ID：200901082274197328 Update date: Jan. 31, 2024

Saku Takashi

Affiliation and department：
Job title： Professor
Other affiliations (1)：

新潟大学名誉教授

Research field (1)： Oral medicine

Research keywords (1)： oral cancer

Research theme for competitive and other funds (60)：

2019 - 2022 Cell competition at the lateral invasion front of oral squamous cell carcinoma
2015 - 2019 ミャンマーにおける噛みタバコ習慣関連口腔がん発症に関する分子病理疫学的研究
2015 - 2018 Hypoxia-responsive MYC promotes the survival and growth of pleomorphic adenoma cells in hypoxic conditions.
2015 - 2018 Phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: a possible driving force for cancer progression
2015 - 2017 Molecular pathways and functional varieties of hemophagocytosis-induced keratinization in oral squamous cell carcinoma cells: from cell death to proliferation and invasion

2013 - 2017 Molecular patho-epidemiological study on the etiological background for oral superficial carcinoma among Asian ethnic groups

2013 - 2016 Proteome analysis of invasion starter molecules in oral squamous cell carcinoma

2012 - 2015 Survival of salivary pleomorphic adenoma cells under the hypoxia-responsive extracellular matrix biosynthesis

2011 - 2015 A molecular pathoepidemiological study on tobacco chewing-related oral cancer in Asian and African areas

2011 - 2013 A novel visualization approach on a 64-row multidetector CT perfusion in the early detection of subclinical cervical lymph node metastases

2010 - 2012 Molecular mechanisms of ghost cell formation and calcification in calcifying cystic odontogenic tumor (CCOT) cell lines

2009 - 2011 The mechanism of signal transduction of perlecan in the tooth enamel organ morphogenesis

2008 - 2011 Molecular patho-epidemiological study on oral superficial carcinoma in East Asia regions

2007 - 2010 Pathogenesis of oral cancer due to chewing habits spread in Asia to East Africa

2007 - 2008 The role of perlecan in the oral mucosa and the skin appendage-Transgenic mice overexpression of perlecan-

2006 - 2008 Molecular and pathology analyses for switching mechanism of stromal inducement in invasive oral carcinoma

2006 - 2007 歯原性角化嚢胞モデルとしてのMsx2ノックアウトマウスの顎骨嚢胞

2006 - 2007 Establishment of the sonogiaphic scanning techniques and diagnostic criteria of intraoral sonography for tongue squamous cell carcinoma

2006 - 2007 Molecular pathological study of mechanism in malignant changes of benign odontogenic tumors

2005 - 2007 Construction of highly individualized dyagnostic sustem by expresson level of biomarker genes

2006 - 2006 口腔粘膜悪性境界病変の病理組織学的診断基準の策定

2005 - 2006 口腔粘膜上皮<胚細胞>の同定とその二方向性分化経路概念の確立

2005 - 2006 The role of basement membrane type heparan sulfate proteoglycan, perlecan, in epithelial morphogenesis -transgenic mice overexpressing perlecan in the epithelial cells-

2004 - 2006 Molecular biologic and pathologic analysis of Epstein-Barr virus infection related salivary lymphoepithelial carcinoma

2003 - 2006 Molecular pathological analysis of oral carcinoma caused by chewing habits in Asia

2004 - 2005 Molecular pathological study of mechanism in malignant changes of oral benign tumors

2004 - 2004 口腔粘膜癌とその境界病変の病理組織学的診断基準のグローバル化策定

2003 - 2004 免疫担当細胞による細胞外基質分子の生合成とその意義-リンパ球・マクロファージの遊走機構基盤と間質改造現象への貢献-

2003 - 2004 Molecular pathological analysis of intraepithelial distribution of extracellular matrix molecules

2002 - 2004 Development of a general information system for dental and oral disease targeting electronic medical record.

2002 - 2004 A new anti-cancer strategy by control ling crosstalk of oral carcinoma cells with extracellular matrix molecules

2002 - 2003 Metastasis-associated genes in salivary adenoid cystic carcinoma and oral squamous cell carcinoma : a differential DNA chip analysis between metastatic and non-metastatic cell systems

2002 - 2003 Molecularbaological study of craniofacial dysmorphology in transgenic mice bearing Apert type mutant Fgfr2 gene

2001 - 2003 Polymorphism in cancer-related genes among oral cancers from the eastern Asian area

2001 - 2003 A new anti-cancer strategy by control ling cross talk of oral carcinoma cells with extra cellular matrix molecules

2002 - 2002 アジア民族の表在型口腔粘膜癌の発生に関する病理疫学的研究

2001 - 2002 口腔粘膜上皮層内に細胞外基質は存在するか

2000 - 2002 Molecular biologic and pathologic study of Epstein-Barr virus infected lymphepithalial carcinomas in salivary gland

2000 - 2001 Microarray gene expression analysis for development prognostic factors for oral squamous cell carcinoma

2000 - 2001 Mutational events of p53 gene in salivary gland tumors

1999 - 2000 Molecular pathologic study of precancerous lesions of the salivary gland

1998 - 2000 Anti-oral cancer strategy by means of inhibition of cellular adhesion to extracellula matrices

1998 - 2000 A variety of molecular crosstalks between extracellular matrices and their cell surface receptors in oral carcinomas

1999 - 1999 唾液腺多形性腺腫の血管に乏しい間質の分子病理学的特性とCT造影性

1997 - 1999 Study on the mechanism of lymph node metastasis using high and low metastatic cell lines established from O-IN.

1997 - 1998 局所的ムコ多糖症としての唾液腺腫瘍-その疾患概念確立のための基礎的研究

1996 - 1997 Stromal remodeling in processes of proliferation, invasion and metastasis of oral carcinoma cells : a molecular pathological study

1996 - 1996 口腔病変におけるウィルス感染のパラフィン切片上ポリメラーゼ連鎖反応による検出

1996 - 1996 Epstein-Barr virus infection in Chinese salivary cancers

1995 - 1996 Extracellular matrix production by salivary gland tumor cells in three-dimensional culture system

1995 - 1996 Analysis of the mecharism of lymph node metastasis of oral carcinomas using O-IN,hamster squamous cell carcinoma with high metastatic potential.

1994 - 1995 Precarcerous or preneoplastic lesions in salivary glands

1994 - 1995 The role of stromal tissue in the development of odontomas

1994 - 1995 ANALYSIS OF GROWTH OF JAW CYSTS BY ASSESSMENT OF CELL PROLIFERATION

1994 - 1995 Dynamic changes of basement membrane molecules and degradation enzymes in stroma remodelled by proliferation and in asion of salivary gland carcinoma cells.

1994 - 1995 Epstein-Barr Virus Infection in Chinese Salivary Cancers

1992 - 1994 Fibroblast growth factor in saliva and oral lesions

1992 - 1994 Analysis of the mechanism of lymph node metastasis of oral carcinomas

1992 - 1993 Biosynthesis and secretory pathway of basement membrane molecules by salivary gland carcinoma cells.

1989 - 1990 硬組織に由来する細胞の機能発現とリソゾ-ム性酵素の役割に関する実験薬理学的研究

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Papers (176)：

Satoshi Maruyama, Manabu Yamazaki, Tatsuya Abé, Jun Cheng, Takashi Saku, Jun-ichi Tanuma. Hypoxia-Induced Biosynthesis of the Extracellular Matrix Molecules, Perlecan and Fibronectin, Promotes the Growth of Pleomorphic Adenoma Cells In Vitro Models. Biomedicines. 2023. 11. 11. 2981-2981
Hitoshi Hara, Tsunemi Misawa, Eri Ishii, Miki Nakagawa, Saki Amemiya, Kenji Amemiya, Toshio Oyama, Takashi Saku. Usefulness of Five-Parameter System Reconfirmed for Cytopathology of Oral Squamous Cell Carcinoma regardless of Differentiation Degree. Acta cytologica. 2022. 1-12
Tetsuo Kiguchi, Yoshito Kakihara, Manabu Yamazaki, Kouji Katsura, Kenji Izumi, Jun-ichi Tanuma, Takashi Saku, Ritsuo Takagi, Makio Saeki. Identification and characterization of R2TP in the development of oral squamous cell carcinoma. Biochemical and Biophysical Research Communications. 2021. 548. 161-166
Tatsuya Abé, Norio Kitagawa, Shohei Yoshimoto, Satoshi Maruyama, Manabu Yamazaki, Tetsuichiro Inai, Shuichi Hashimoto, Takashi Saku. Keratin 17-positive Civatte bodies in oral lichen planus-distribution variety, diagnostic significance and histopathogenesis. Scientific Reports. 2020. 10. 1
Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abé, Masayuki Tsuneki, Hiroko Kato, Kenji Izumi, Jun-Ichi Tanuma, Jun Cheng, Takashi Saku. Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression. Experimental cell research. 2020. 392. 1. 112013-112013

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MISC (180)：

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Books (5)：

口腔病理アトラス・第3版
文光堂 2018
新口腔病理学
2008
病理学・第2版
医歯薬出版 2008
口腔病理アトラス・第2版
文光堂 2006
口腔病理アトラス
文光堂 1998

Lectures and oral presentations (1)：

顎骨嚢胞
(日本病理学会 2002)

Works (5)：

科学研究費補助金基盤研究(C) 口腔粘膜悪性境界病変の病理組織学的診断基準の策定
2006 - 2007
Grant-in-Aid
2006 - 2007
科学研究費補助金基盤研究(C) 口腔粘膜癌とその境界病変の病理組織学的診断基準のグローバル化策定
2004 - 2005
科学研究費補助金基盤研究(B)(2)
2001 - 2004
Grant-in-Aid for Scientific Research (B)
2001 - 2004

Education (2)：

1976 - 1980 Kagoshima University School of Medicine
1970 - 1976 Tokyo Medical and Dental University Faculty of Dentistry

Professional career (1)：

医学博士 (鹿児島大学)

Work history (4)：

2018/04 - 現在 Fukuoka Dental College visiting professor
2016/04 - 2018/03 Osaka Dental University visiting professor
2004/04 - 2016/03 Niigata University Graduate School of Medical and Dental Sciences professor
1990/12 - 2004/03 Niigata University Faculty of Dentistry professor

Association Membership(s) (3)：

THE JAPANESE SOCIETY OF ORAL PATHOLOGY , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE SOCIETY OF PATHOLOGY

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