Sakurai Hiroaki

サクライヒロアキ | Sakurai Hiroaki

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.pha.u-toyama.ac.jp/cliche2/index-j.html

Research field (2)： Tumor biology , Pharmaceuticals - health and biochemistry

Research keywords (3)：分子腫瘍学 , シグナル伝達 , Signal transduction

Research theme for competitive and other funds (19)：

2022 - 2025 Cancer pathophysiology and treatment from the perspective of dual-mode control of EGFR
2019 - 2022 Alternative activation mechanisms of receptor tyrosine kinases in inflammation-induced cancer progression
2016 - 2019 Noncanonical activation of receptor tyrosine kinases: next target mechanisms for cancer progression
2016 - 2018 Functional interactions between inflammatory signal and growth singaling in the Warburg effect in cancer cells
2014 - 2016 Effects of a TAK1 inhibitor on radiation-and heat-induced cell killing

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Papers (109)：

Yutaka Yasuta, Ryuya Kaminaka, Shutaro Nagai, Shuto Mouri, Katsuya Ishida, Akihiro Tanaka, Yue Zhou, Hiroaki Sakurai, Satoru Yokoyama. Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodia. Scientific Reports. 2024. 14. 1
Yue Zhou, Jun-Ichiro Takahashi, Hiroaki Sakurai. New Directions for Advanced Targeting Strategies of EGFR Signaling in Cancer. Biological & pharmaceutical bulletin. 2024. 47. 5. 895-903
Yue Zhou, Ryota Oki, Akihiro Tanaka, Leixin Song, Atsushi Takashima, Naru Hamada, Satoru Yokoyama, Seiji Yano, Hiroaki Sakurai. Cellular stress induces non-canonical activation of the receptor tyrosine kinase EphA2 through the p38-MK2-RSK signaling pathway. Journal of Biological Chemistry. 2023. 299. 5
Aki Kohyama, Aya Shiuchi, Yue Zhou, Masaru Tanioka, Kenji Sugimoto, Hiroaki Sakurai, Yuji Matsuya. Controllable conformation and reactivity of bicyclic α-methylene cyclopentanones and their NF-κB pathway inhibitory activity. Organic & Biomolecular Chemistry. 2023
Jun-Ichiro Takahashi, Shiori Nakamura, Iimi Onuma, Yue Zhou, Satoru Yokoyama, Hiroaki Sakurai. Synchronous intracellular delivery of EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis. Scientific reports. 2022. 12. 1. 11561-11561

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MISC (74)：

岩原宏幸, 岩田悠輔, 名取香奈子, 小澤龍彦, ZHOU Yue, 定清直, 横山悟, 櫻井宏明. Phosphorylation of TAB1 by Src: A new signaling pathway of oxidative stress. 衛生薬学・環境トキシコロジー講演要旨集. 2020. 2020
大賀英司, 田中智大, 小澤龍彦, 村口篤, 櫻井宏明. p38活性化はEGFR Ser-1015のリン酸化を介したエンドサイトーシスを誘導する. 日本生化学会大会(Web). 2017. 90th
河崎優希, 崎村綾香, パクチョルミン, 都丸里佳, 小澤龍彦, 周越, 成田香織, 村口篤, 櫻井宏明. ErbB2/ErbB3ヘテロ二量体におけるERKを介したErbB2Thr-677リン酸化によるフィードバック制御. 日本分子生物学会年会プログラム・要旨集(Web). 2016. 39th
河崎優希, 崎村綾香, Park Chulmin, 周越, 都丸里佳, 成田香織, 小澤龍彦, 村口篤, 櫻井宏明. ERKを介したErbB2 Thr-677リン酸化によるErbB2/ErbB3ヘテロ二量体のフィードバック阻害機構. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [2P0209]-[2P0209]
周越, 山田直樹, 田中智大, 堀隆, 横山悟, 早川芳弘, 矢野聖二, 福岡順也, 小泉桂一, 済木育夫, et al. RSKを介したEphA2 Ser-897リン酸化による細胞運動の制御機構. 日本癌学会総会記事. 2015. 74回. P-3038

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Patents (1)：

Books (2)：

Education (3)：

Professional career (1)：

Work history (6)：

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Awards (1)：

Association Membership(s) (7)：

日本ケミカルバイオロジー学会 , 日本薬学会 , 日本がん転移学会 , 日本がん分子標的治療学会 , 日本癌学会 , 日本生化学会 , 日本分子生物学会

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