Rchr
J-GLOBAL ID：200901082605993847
Update date: Feb. 01, 2024
Nagai Hirokazu
ナガイ ヒロカズ | Nagai Hirokazu
Affiliation and department：
Job title：
准教授
Research field (1)：
Surgical dentistry
Research keywords (2)：
口腔外科学
, Oral and maxillofacial surgery
Research theme for competitive and other funds (34)：
- 2022 - 2025 ナノ粒子化した炭酸アパタイトによる多剤徐放を目指した新規骨置換型人工骨の開発
- 2018 - 2021 Development of bioresorbable artificial bone using hydrogel and ceramics
- 2016 - 2020 Development of the bone regenerative medicine with the porous carbonate apatite made from calcium sulfate and bone marrow stem cell
- 2016 - 2019 The inducing differentiation of iPS cells and salivary gland regeneration that reproduces the epithelial-mesenchymal interaction in initiation stage
- 2015 - 2019 the examination of microRNA related with lymph node metastasis
- 2015 - 2018 Novel immunotherapy with HDAC inhibitor and OK-432 targeting PD-1
- 2015 - 2018 Bone regeneration using a hybrid-type artificial bone consisted of iPS cells and low crystalline carbonate apatite
- 2014 - 2018 Role of miR-518c-5p on the metastasis of oral cancer via CXCR4 system
- 2015 - 2017 We investigate the essence of osseointegration and biointegration in the cell
- 2013 - 2016 Development of combination therapy, targeting NF-kB and CXCR4-related miRNA in oral cancer
- 2013 - 2016 Development of the anticancer drug sensitivity testing and elucidation of the resistance mechanism for oral cancer using new cultural method CTOS
- 2013 - 2016 Fabrication of gelatin-coated carbonate apatite foam and its application on reconstruction of jaw
- 2013 - 2015 Promoting differentiation of osteoblasts from induced pluripotent stem (iPS) cells using scaffolds recreating the bone tissue microenvironment.
- 2012 - 2015 Development of tooth regenerative therapy using the interaction between immortalized odontogenic cell and iPS cells.
- 2012 - 2015 Development of novel molecular therapy target at epigenetics against salivary gland cancer
- 2012 - 2015 Analysis of PARP as nobel potencial therapeutic targets in oral cancer
- 2010 - 2012 The elucidation of a mechanotransduction mechanism to the joint destruction in the temporomandibular joint synovial cell
- 2010 - 2011 Establisment of differentiation method from induced pluripotent stem(iPS) cells to osteoblasts via mesenchymal stem cells
- 2009 - 2011 Development of tooth regenerative therapy applied molecular mechanisms of epithelial-mesenchymal interactions in tooth morphogenesis
- 2009 - 2011 Development of new oral cancer treatment as molecular target for antiapoptosis protein and NF-kB
- 2007 - 2008 pplication to oral cancer of the sentinel lymph node identificationmethod using lymphangiography CT
- 2007 - 2008 Development of tooth regenerative therapy using the low crystalline carbonate apatite and mesenchymal stem cells derivedfrom adipose tissue
- 2006 - 2008 Development of the cell transplantation therapy for the tooth regeneration using the committed progenitor cell of the tooth established from the tooth germ
- 2006 - 2008 Applications of bone-replaceable carbonate spatife for jawbone recanstruetion and for scaffold of bone regeneration
- 2006 - 2008 不死化歯由来細胞株と生体内吸収性材料を用いた歯の再生医療用スキャフォールドの開発
- 2006 - 2007 Molecular biological analysis of bone metabolism by compressive mechanical stress in human synovial cells of the temporomandibular joint
- 2005 - 2006 Analysis of the stress signaling pathway using synovial cells from human temporomandibular joint and application to a gene therapy.
- 2004 - 2006 Elucidation of temporomandibular disorders using contrast-enhancement MRI and analysis of synovial fluid/tissue
- 2004 - 2005 Fabrication of scaffolds made of bioresorbable polymer for bone and cartilage regeneration and its bone reconstruction using transplantation with the blood vessel pattern.
- 2002 - 2004 Effect of mechanical stress on the osteoblastic differentiation of human mesenchymal stem cell
- 2002 - 2004 顎関節構成体のメカニカルストレスに対する細胞応答の遺伝子解析による解明
- 2003 - 骨再生に関する研究
- 2001 - 顎関節症に関する研究
- 2001 - Study on TMD
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Papers (67)：
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武田 裕利, 永井 宏和, 森島 浩允, 鈴木 飛佳理, 大竹 義雄, 高山 慎騎, 宮下 仁, 山内 健介, 高橋 哲. リンパ球数は薬剤関連顎骨壊死に対する外科的治療の予後予測因子となりうる. 日本口腔科学会雑誌. 2022. 71. 2. 138-138
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岩間 亮介, 三浦 桂一郎, 宮下 仁, 木村 太, 柳沢 佑太, 纐纈 衆, 山内 健介, 永井 宏和, 熊本 裕行, 高橋 哲. 口腔粘膜蛍光観察機器を用いた口腔扁平上皮癌切除断端の評価. 頭頸部癌. 2022. 48. 2. 155-155
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柳沢 佑太, 三浦 桂一郎, 宮下 仁, 纐纈 衆, 梶田 倫功, 武田 裕利, 森 士朗, 野上 晋之介, 山内 健介, 永井 宏和, et al. 当科におけるAYA世代口腔癌患者に関する臨床的検討. 頭頸部癌. 2022. 48. 2. 220-220
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深瀬 了嗣, 梶田 倫功, 宮下 仁, 纐纈 衆, 三浦 桂一郎, 野上 晋之介, 山内 健介, 永井 宏和, 熊本 裕行, 高橋 哲. 下顎歯肉に転移した肝細胞癌の1例. 頭頸部癌. 2022. 48. 2. 232-232
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柳沢 佑太, 三浦 桂一郎, 宮下 仁, 纐纈 衆, 梶田 倫功, 武田 裕利, 森 士朗, 野上 晋之介, 山内 健介, 永井 宏和, et al. 当科におけるAYA世代口腔癌患者に関する臨床的検討. 頭頸部癌. 2022. 48. 2. 220-220
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MISC (106)：
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小川武則, 大越明, 石田英一, 石井亮, 石川智彦, 宮下仁, 永井宏和, 佐藤奈央子, 小山重人, 高地崇, et al. 下歯肉癌手術における下顎骨切除範囲と術後機能の検討. 頭頸部癌. 2018. 44. 2. 168-168
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玉谷 哲也, 高丸 菜都美, 永井 宏和, 宮本 洋二. 口腔扁平上皮癌におけるSOX2発現の臨床病理学的意義. 日本癌学会総会記事. 2016. 75回. P-2288
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藤澤 健司, 永井 宏和, 大江 剛, 高丸 菜都美, 都留 寛治, 石川 邦夫, 宮本 洋二. 低結晶性炭酸アパタイトのインプラント領域への応用 イヌ顎骨へのインプラント体との同時埋植. 日本口腔インプラント学会学術大会抄録集. 2016. 46回. P-28
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山村 佳子, 藤澤 健司, 鎌田 久美子, 高丸 菜都美, 工藤 景子, 大江 剛, 工藤 隆治, 高橋 章, 玉谷 哲也, 永井 宏和, et al. 口腔がん患者の歯科疾患罹患状況. 日本歯科人間ドック学会誌. 2016. 11. 1. 29-32
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Novel Concepts of Surgery and Progress of Operative Procedure. Journal of Oral Health and Biosciences. 2016. 29. 1. 1-15
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Education (4)：
- - 2001 Akita University
- - 2001 Akita University Graduate School, Division of Medicine Biochemisyry
- - 1993 Tohoku University Faculty of Dentistry
- - 1993 Tohoku University Faculty of Dentistry
Professional career (1)：
- Ph. D. in Medicine (Akita University)
Work history (4)：
- 2001 - - Assistant professor, School of Medicine, University of
- 1996 - 1997 Assistant professor, School of Medicine, University of
- 1993 - 1995 Junior Resident, School of Dentistry, University of
- 1995 - Senior Resident, School of Medicine, University of
Association Membership(s) (6)：
日本口腔インプラント学会
, 日本顎関節学会
, 日本口腔科学会
, 日本生化学会
, 日本癌学会
, 口腔外科学会
