Rchr
J-GLOBAL ID：200901082606738158   Update date: Feb. 23, 2024

Hari Yoshiyuki

ハリ ヨシユキ | Hari Yoshiyuki
Affiliation and department：
Tokushima Bunri University Faculty of Pharmaceutical Sciences

About Tokushima Bunri University Faculty of Pharmaceutical Sciences


Job title： Professor
Homepage URL  (1)： http://p.bunri-u.ac.jp/lab06/index.html
Research field  (2)： Pharmaceuticals - chemistry and drug development ,  Biochemistry
Research theme for competitive and other funds  (8)：
  • 2020 - 2023 アンチセンス核酸の脱PS化を志向したRNase H活性を持つ修飾核酸の開発
  • 2017 - 2020 Development of a pinpoint functionalization method of nucleic acids
  • 2010 - 2016 Establishment of Integrative Multi-level Systems Biology and its Applications
  • 2010 - 2015 Development of synthetic methodology to supply materials for understanding of physiological system
  • 2012 - 2014 Identification of plasma membrane leucine receptor and elucidation of its link to mTOR signaling pathway
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Papers (112)：
  • Yu Mikame, Honoka Eshima, Haruki Toyama, Juki Nakao, Misaki Matsuo, Tsuyoshi Yamamoto, Yoshiyuki Hari, Jun A Komano, Asako Yamayoshi. Development and Crosslinking Properties of Psoralen-Conjugated Triplex-Forming Oligonucleotides as Antigene Tools Targeting Genome DNA. ChemMedChem. 2023. 18. 21. e202300348
  • Yuta Ito, Chisa Takemori, Yoshiyuki Hari. Chemical Conversion of 5-Fluoromethyl- and 5-Difluoromethyl-Uracil Bases in Oligonucleotides Using Postsynthetic Modification Strategy. Current Protocols in Nucleic Acid Chemistry. 2023. 3. 7. e837
  • Yasufumi Fuchi, Kouki Watanabe, Misa Shoji, Yuta Ito, Yoshiyuki Hari. Synthesis of purine derivatives of Me-TaNA and properties of Me-TaNA-modified oligonucleotides. Organic and Biomolecular Chemistry. 2023. 21. 25. 5203-5213
  • Yasufumi Fuchi, Kazuki Yamamoto, Yuta Ito, Yoshiyuki Hari. Benzo-Fused 7-Oxabicyclo[22.1]heptane-2,3-diol Derivatives as Universal Linkers for Solid-Phase Oligonucleotide Synthesis. Synthesis (Germany). 2023. 55. 7. 1112-1122
  • Kazuki Yamamoto, Yasufumi Fuchi, Yuta Ito, Yoshiyuki Hari. Expansion of Phosphoramidite Chemistry in Solid-Phase Oligonucleotide Synthesis: Rapid 3′-Dephosphorylation and Strand Cleavage. Journal of Organic Chemistry. 2023. 88. 5. 2726-2734
ｍore...
MISC (9)：
  • Yuta Ito, Yoshiyuki Hari. Synthesis of Nucleobase-Modified Oligonucleotides by Post-Synthetic Modification in Solution. The Chemical Record. 2022. 22. 5. e202100325
  • Yoshiyuki Hari. Bridged Nucleosides as Building Blocks of Oligonucleotides: Synthesis and Properties. HETEROCYCLES. 2020. 100. 5. 681-717
  • Duplex-forming ability. 2016. 74. 2. 169-169
  • Yoshiyuki Hari, Satoshi Obika. Synthesis and Properties of 2’,4’-Bridged Nucleic Acids Containing Multiple Heteroatoms in the Bridges. Journal of Synthetic Organic Chemistry, Japan. 2016. 74. 2. 141-153
  • Yoshiyuki Hari. Development of Artificial Nucleic Acid That Recognizes a CG Base Pair in Triplex DNA Formation. YAKUGAKU ZASSHI. 2013. 133. 11. 1201-1208
ｍore...
Books (7)：
  • 核酸科学ハンドブック
    講談社 2020
  • 2'-C,4'-C-Ethyleneoxy-bridged 2'-deoxyribonucleic acids (EoDNAs) with thymine nucleobases: Synthesis, duplex-forming ability and enzymatic stability
    Humana Press 2019
  • 2',4'-Bridged nucleic acids containing plural heteroatoms in the bridge moiety
    Springer Singapore 2018
  • Site-specific modification of nucleobases in oligonucleotides
    Springer Singapore 2018
  • 2',4'-Bridged nucleic acids for targeting double-stranded DNA
    Springer 2016
ｍore...
Education (2)：
  • 1997 - 2002 Osaka University Graduate School of Pharmaceutical Sciences
  • 1993 - 1997 Osaka University School of Pharmaceutical Sciences
Professional career (1)：
  • PhD (Osaka University)
Work history (8)：
  • 2015/04 - 現在 Tokushima Bunri University Faculty of Pharmaceutical Sciences
  • 2013/04 - 2015/03 Osaka University Graduate School of Pharmaceutical Sciences
  • 2009/01 - 2013/03 Osaka University Graduate School of Pharmaceutical Sciences
  • 2008/04 - 2009/01 Nagoya City University Graduate School of Pharmaceutical Sciences
  • 2007/04 - 2008/03 Nagoya City University Graduate School of Pharmaceutical Sciences
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Association Membership(s) (5)：
THE CHEMICAL SOCIETY OF JAPAN ,  Japan Society of Nucleic Acids Chemistry ,  The Nucleic Acids Therapeutics Society of Japan ,  The Society of Synthetic Organic Chemistry, Japan ,  The Pharmaceutical Society of Japan
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