Hari Yoshiyuki

ハリヨシユキ | Hari Yoshiyuki

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://p.bunri-u.ac.jp/lab06/index.html

Research field (2)： Pharmaceuticals - chemistry and drug development , Biochemistry

Research theme for competitive and other funds (8)：

2020 - 2023 アンチセンス核酸の脱PS化を志向したRNase H活性を持つ修飾核酸の開発
2017 - 2020 Development of a pinpoint functionalization method of nucleic acids
2010 - 2016 Establishment of Integrative Multi-level Systems Biology and its Applications
2010 - 2015 Development of synthetic methodology to supply materials for understanding of physiological system
2012 - 2014 Identification of plasma membrane leucine receptor and elucidation of its link to mTOR signaling pathway

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Papers (116)：

Misa Shoji, Yasufumi Fuchi, Yuta Ito, Yoshiyuki Hari. Synthesis and characterization of oligonucleotides containing 2′-O,4′-C-methyleneoxy-bridged 5-methyluridine with an unsubstituted bridge. Tetrahedron. 2024. 163
Yuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari. Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion. Organic and Biomolecular Chemistry. 2024. 22. 17. 3510-3517
Yu Mikame, Honoka Eshima, Haruki Toyama, Juki Nakao, Misaki Matsuo, Tsuyoshi Yamamoto, Yoshiyuki Hari, Jun A Komano, Asako Yamayoshi. Development and Crosslinking Properties of Psoralen-Conjugated Triplex-Forming Oligonucleotides as Antigene Tools Targeting Genome DNA. ChemMedChem. 2023. 18. 21. e202300348
Yasufumi Fuchi, Miho Kawaguchi, Yuta Ito, Yoshiyuki Hari. Synthesis and Properties of 2′-Deoxyadenosine Mimics Bearing a Thieno[3,2- d ]pyrimidine Ring. Synlett. 2023. 35. 6. 716-720
Yuta Ito, Chisa Takemori, Yoshiyuki Hari. Chemical Conversion of 5-Fluoromethyl- and 5-Difluoromethyl-Uracil Bases in Oligonucleotides Using Postsynthetic Modification Strategy. Current Protocols in Nucleic Acid Chemistry. 2023. 3. 7. e837

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MISC (9)：

Yuta Ito, Yoshiyuki Hari. Synthesis of Nucleobase-Modified Oligonucleotides by Post-Synthetic Modification in Solution. The Chemical Record. 2022. 22. 5. e202100325
Yoshiyuki Hari. Bridged Nucleosides as Building Blocks of Oligonucleotides: Synthesis and Properties. HETEROCYCLES. 2020. 100. 5. 681-717
Duplex-forming ability. 2016. 74. 2. 169-169
Yoshiyuki Hari, Satoshi Obika. Synthesis and Properties of 2’,4’-Bridged Nucleic Acids Containing Multiple Heteroatoms in the Bridges. Journal of Synthetic Organic Chemistry, Japan. 2016. 74. 2. 141-153
Yoshiyuki Hari. Development of Artificial Nucleic Acid That Recognizes a CG Base Pair in Triplex DNA Formation. YAKUGAKU ZASSHI. 2013. 133. 11. 1201-1208

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Books (7)：

核酸科学ハンドブック
講談社 2020
2'-C,4'-C-Ethyleneoxy-bridged 2'-deoxyribonucleic acids (EoDNAs) with thymine nucleobases: Synthesis, duplex-forming ability and enzymatic stability
Humana Press 2019
2',4'-Bridged nucleic acids containing plural heteroatoms in the bridge moiety
Springer Singapore 2018
Site-specific modification of nucleobases in oligonucleotides
Springer Singapore 2018
2',4'-Bridged nucleic acids for targeting double-stranded DNA
Springer 2016

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Education (2)：

1997 - 2002 Osaka University Graduate School of Pharmaceutical Sciences
1993 - 1997 Osaka University School of Pharmaceutical Sciences

Professional career (1)：

PhD (Osaka University)

Work history (8)：

2015/04 - 現在 Tokushima Bunri University Faculty of Pharmaceutical Sciences
2013/04 - 2015/03 Osaka University Graduate School of Pharmaceutical Sciences
2009/01 - 2013/03 Osaka University Graduate School of Pharmaceutical Sciences
2008/04 - 2009/01 Nagoya City University Graduate School of Pharmaceutical Sciences
2007/04 - 2008/03 Nagoya City University Graduate School of Pharmaceutical Sciences

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Association Membership(s) (5)：

THE CHEMICAL SOCIETY OF JAPAN , Japan Society of Nucleic Acids Chemistry , The Nucleic Acids Therapeutics Society of Japan , The Society of Synthetic Organic Chemistry, Japan , The Pharmaceutical Society of Japan

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