J-GLOBAL ID:200901082606738158   Update date: Dec. 02, 2019

HARI Yoshiyuki

ハリ ヨシユキ | HARI Yoshiyuki
Affiliation and department:
Job title: Professor
Homepage URL  (2): http://p.bunri-u.ac.jp/lab06/index.htmlhttp://p.bunri-u.ac.jp/lab06/index.html
Research field  (3): Drug development chemistry ,  Chemical pharmacy ,  Bio-related chemistry
Papers (97):
  • Ito Y, Mizuno K, Domoto K, Hari Y. Synthesis and hybridization properties of iridium(III) polypyridyl complex-conjugated oligonucleotide. Nucleosides, Nucleotides & Nucleic Acids. 2020. in press
  • Osawa T, Onishi Y, Wakita S, Ito Y, Hari Y. Synthesis and hybridizing property of oligonucleotides including 2'-C,4'-C-ethyleneoxy-bridged 2'-deoxyadenosine with an exocyclic methylene unit. Heterocycles. 2020. 101. in press
  • Osawa T, Kim H, Shoji M, Saijo M, Dohi M, Ito Y, Obika S, Hari Y. Synthesis of 2'-C,4'-C-methyleneoxy-bridged thymidine derivatives and properties of modified oligonucleotides. The Journal of Organic Chemistry. 2019. 84. 13336-13344
  • Ito Y, Yamamoto K, Hari Y. Construction of pyrimidine bases bearing carboxylic acid equivalents at the C5 position by postsynthetic modification of oligonucleotides. Current Protocols in Nucleic Acid Chemistry. 2019. 78. 1. e91
  • Ito Y, Tsutsui N, Osawa T, Hari Y. Synthesis of the methyl analog of 2'-O,4'-C-ethylene-bridged 5-methyluridine via intramolecular radical cyclization and properties of the modified oligonucleotides. The Journal of Organic Chemistry. 2019. 84. 14. 9093-9100
Books (6):
  • 2’-O,4’-C-Methyleneoxymethylene bridged nucleic acid (2’,4’-BNA<sup>COC</sup>)
    Humana Press 2011
  • 1-Diazo-1-silylalkanes (Update 2010)
    Georg Thieme Verlag 2011
  • 2',4'-Bridged nucleic acids for targeting double-stranded DNA
    Springer 2016
  • Site-specific modification of nucleobases in oligonucleotides
    Springer Singapore 2018
  • 2',4'-Bridged nucleic acids containing plural heteroatoms in the bridge moiety
    Springer Singapore 2018
Education (2):
  • - 1997 Osaka University Faculty of Pharmaceutical Science
  • - 2002 Osaka University Graduate School, Division of Pharmaceutical Sciences
Professional career (1):
  • PhD (Osaka University)
Association Membership(s) (5):
THE CHEMICAL SOCIETY OF JAPAN ,  Japan Society of Nucleic Acids Chemistry ,  The Society of Synthetic Organic Chemistry, Japan ,  The Pharmaceutical Society of Japan ,  The Nucleic Acids Therapeutics Society of Japan
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