Komatsu Yoshito

コマツヨシト | Komatsu Yoshito

Affiliation and department：
Job title： Clinical Professor, Associate Professor

Research field (1)： Tumor diagnostics and therapeutics

Research keywords (10)： GIST , Cancer Chemotherapy , 緩和ケア , 支持療法 , ゲノム医療 , 免疫チェックポイント阻害薬 , 薬物療法 , 消化器癌(腫瘍学) , Gastroenterology , Clinical Oncology

Research theme for competitive and other funds (5)：

2022 - 2025 PARP inhibitor resistance in cancer stem cells in hepatocelular carcinoma
2014 - 2017 Analysis of cancer stem cell niche by using esophageal orgnotypic 3D culture system
2013 - 2016 RNA binding proteins modulate drug sensitivity of cancer chemotherapy via EMT related proteins.
消化器癌の化学療法固形癌の化学療法
GI oncology Cancer Chemotherapy Clinical Study

Papers (296)：

Yoshitaka Saito, Yoh Takekuma, Yoshito Komatsu, Mitsuru Sugawara. Impact of renal impairment on early development of severe neutropenia with trifluridine/tipiracil treatment for metastatic colorectal cancer. Scientific reports. 2024. 14. 1. 26990-26990
Yuta Toji, Shintaro Takeuchi, Yuma Ebihara, Yo Kurashima, Kazuaki Harada, Mariko Hayashi, Hirotake Abe, Hideyuki Wada, Satoko Yorinaga, Toshiaki Shichinohe, et al. Perioperative chemotherapy with nivolumab for HER2-negative locally advanced gastric cancer: a case series. Surgical case reports. 2024. 10. 1. 200-200
Naoko Iida, Mitsuho Imai, Wataru Okamoto, Takeshi Kato, Taito Esaki, Ken Kato, Yoshito Komatsu, Satoshi Yuki, Toshiki Masuishi, Tomohiro Nishina, et al. Novel ERBB2 Variant Potentially Associated with Resistance against Anti-HER2 Monoclonal Antibody-Based Therapy in ERBB2-Amplified Metastatic Colorectal Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2024. OF1-OF12
Hiroshi Nakatsumi, Yoshito Komatsu, Kazuaki Harada, Yasuyuki Kawamoto, Satoshi Yuki, Kentaro Sawada, Atsushi Ishiguro, Susumu Sogabe, Takayuki Ando, Yusuke Sasaki, et al. A multicenter, prospective, phase II trial of second-line aflibercept plus FOLFIRI in patients with metastatic colorectal cancer refractory to an anti-EGFR antibody: HGCSG1801. International journal of cancer. 2024
Hideaki Bando, Daisuke Kotani, Hironaga Satake, Tetsuya Hamaguchi, Manabu Shiozawa, Masahito Kotaka, Toshiki Masuishi, Hisateru Yasui, Yoshinori Kagawa, Yoshito Komatsu, et al. QUATTRO-II randomized trial: CAPOXIRI+bevacizumab vs. FOLFOXIRI+bevacizumab as first-line treatment in patients with mCRC. Med (New York, N.Y.). 2024

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MISC (624)：

Takayuki Yoshino, Jun Watanabe, Kohei Shitara, Hirofumi Yasui, Hisatsugu Ohori, Manabu Shiozawa, Kentaro Yamazaki, Eiji Oki, Takeo Sato, Takeshi Naitoh, et al. Panitumumab (PAN) plus mFOLFOX6 versus bevacizumab (BEV) plus mFOLFOX6 as first-line treatment in patients with RAS wild-type (metastatic colorectal cancer (mCRC): Results from the phase 3 PARADIGM trial. JOURNAL OF CLINICAL ONCOLOGY. 2022. 40. 17
塚田祐一郎, 坂東英明, 稲守宏冶, 冨樫庸介, 結城敏志, 小松嘉人, 本間重紀, 武冨紹信, 植村守, 加藤健志, et al. 大腸癌周術期治療の臨床開発と将来展望進行直腸癌に対する化学放射線療法と免疫チェックポイント阻害剤を用いた術前治療. 日本癌治療学会学術集会抄録集. 2021. 59回. SY2-4
Koji Inamori, Yosuke Togashi, Hideaki Bando, Yuichiro Tsukada, Shota Fukuoka, Ayako Suzuki, Yutaka Suzuki, Daisuke Kotani, Motohiro Kojima, Makoto Fukui, et al. Efficacy predictors of preoperative CRT and consolidation nivolumab in patients with locally advanced rectal cancer. ANNALS OF ONCOLOGY. 2021. 32. S343-S343
Yoshitaka Honma, Yukinori Kurokawa, Akira Sawaki, Yoichi Naito, Shiro Iwagami, Hideo Baba, Yoshito Komatsu, Toshirou Nishida, Toshihiko Doi. Randomized, double-blind, placebo (PL)-controlled, phase III trial of pimitespib (TAS-116), an oral inhibitor of heat shock protein 90 (HSP90), in patients (pts) with advanced gastrointestinal stromal tumor (GIST) refractory to imatinib (IM), sunitinib (SU) and regorafenib (REG). JOURNAL OF CLINICAL ONCOLOGY. 2021. 39. 15
Hideaki Bando, Daisuke Kotani, Masahito Kotaka, Akihito Kawazoe, Toshiki Masuishi, Hironaga Satake, Hiroya Taniguchi, Kentaro Yamazaki, Takeharu Yamanaka, Eiji Oki, et al. Quadruplet regimen with capecitabine, irinotecan, oxaliplatin, and bevacizumab in chemo-naive patients with metastatic colorectal cancer: Results from the safety lead-in of QUATTRO-II study. JOURNAL OF CLINICAL ONCOLOGY. 2021. 39. 3

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Books (13)：

消化器がん化学療法副作用マネジメント
メジカルビュー社 2019 ISBN:9784758318068
Gastrointestinal Stromal Tumor
2019
Chapter 8. Gastrointestinal Stromal Tumor Adjuvant Chemotherapy: Current Practices, Efficacy and Future Directions
2018
安全ながん薬物療法のために知っておきたい薬のハンドブック
ヴァンメディカル 2017 ISBN:9784860921255
消化器がん化学療法副作用マネジメント : プロのコツ
メジカルビュー社 2014 ISBN:9784758303781

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Works (2)：

『CPT-11を用いた消化器癌化学療法』
2002 -
札幌薬剤師会学術講演会『消化器癌に対する薬物療法』
2002 -

Education (3)：

2001 - 現在 Hokkaido University Graduate School of Medicine
1989 - 現在 Tokyo Medical University
1989 - 2001 Hokkaido University School of Medicine

Professional career (1)：

医学博士 (北海道大学)

Work history (15)：

2018/10 - 現在 Hokkaido University Hokkaido University Hospital
2011/04 - 現在 Hokkaido University Hokkaido University Hospital
2008/01 - 2011/03 Hokkaido University Hokkaido University Hospital
2007/12 - 2008/01 Hokkaido University Hokkaido University Hospital
2008 - - 腫瘍センター准教授

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Committee career (10)：

- 現在日本消化器内視鏡学会支部評議員
- 現在日本消化器病学会評議員
- 現在日本大腸肛門病学会代議員
- 現在日本胃癌学会評議員
- 現在日本臨床腫瘍学会協議委員

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Awards (2)：

2009/10 - 日本癌治療学会優秀演題賞
2003/10 - 17th Asia Pacific Cancer Conference Best Poster AWARD

Association Membership(s) (19)：

日本緩和医療学会 , 日本胃癌学会 , 米国臨床腫瘍学会 , 日本大腸肛門病学会 , 日本消化器病学会 , 日本癌学会 , 食道癌研究会 , GIST研究会 , 欧州臨床腫瘍学会 , 日本内科学会 , 日本消化器学会 , 北海道食道癌研究会 , 北海道消化器癌化学療法研究会 , American Society of Clinical Oncology , European Society for Medical Oncology , 日本がん予防学会 , 日本消化器内視鏡学会 , 日本消化管学会 , 北海道癌治療研究会

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