2021 - 2024 Analysis of galactose carbohydrates regulating homing and differentiation of HSC in the bone marrow niche
2020 - 2024 Development of degron system for cancer therapy
2019 - 2022 Establishment of new ADHD model mice based on ganglioside deficiency
2018 - 2021 Establishment of a novel cancer therapy using degron system in mice
2017 - 2020 Functions of B4galt1 in the homing of hematopoietic stem cells.
2016 - 2019 Attempt to establish totipotent stem cells using degron system
2016 - 2019 Establishment of new mental disease model mouse by heterochromatin factor HP1 deficiency
2016 - 2019 Study on neurological disorder caused by ganglioside-deficiency and therapeutics by glycolipid supplement
2015 - 2018 Analysis of gut microbiota and gut immunity in the development of IgA nephropathy using its mouse model
2013 - 2016 The roles of histone modifications in the perinatal period.
2013 - 2016 Analysis of brain functions regulated by histone modification and development of psychiatric disorder animal models
2011 - 2013 Identification of novel homing molecules of hematopoietic stem cells and development of efficient bone marrow transfer methods by modifying carbohydrates
2011 - 2013 The development and demonstration of methodology to elucidate the sugar chain function and glycosyltransferase knockout mouse phenotype.
2011 - 2012 生殖細胞の発生・分化においてヒストン修飾因子が果たす制御機構の解析
2010 - 2012 The role of carbohydrates including galactose and sialic acids in higher brain functions
2009 - 2011 Characterization of AEP/Legumain-deficient mice as a new model of lysosome disease
2009 - 2010 始原生殖細胞の初期分化におけるHP1γとヒストン修飾の機能解析
2007 - 2010 Genesis and physiologic significance of secretory RAGE-a new vasoprotective factor
2007 - 2009 Development of mouse models for human diseases caused by impaired glycosylation and analysis of their mechanisms
2006 - 2008 Characterization of AEP/Legumain-deficient mice as a model of hemophagocytic syndrome-like disease
2006 - 2007 生殖細胞のインプリンティングおよび減数分裂におけるHP1γの機能解明
2005 - 2006 β4-ガラクトース転移酵素-I欠損によるIga腎症発症機構の解析
2004 - 2005 Development of a fundamental technology, which is applicable to drug development and therapeutic applications through analysis of sulfated glycosaminoglycan chains
2004 - 2004 自己免疫疾患におけるアスパラギンエンドペプチダーゼによる免疫記憶の調節
2003 - 2004 ORC4変異マウスを用いた個体レベルでの細胞周期研究
2003 - 2004 Functional analysis of carbohydrate antigens in chemically induced tumor cells derived from beta-1,4-galactosyltransferase-I knockout mice
2002 - 2003 改良遺伝子トラップ法による新規発生制御遺伝子の単離と機能解析
2001 - 2003 Elucidation of individual roles of the galactosyl|ransferase gene family using gene knockout mice
2001 - 2003 Analysis of the biosynthetic mechanism and functions of glycosaminogycans by manipulating the genes encoding biosynthetic enzymes.
2003 - 哺乳類発生過程のエピジェネティクスによる制御機構の解析
2003 - Epigenetic regulation of mammalian development
2001 - 2001 糖転移酵素遺伝子欠損マウスを用いた発癌・転移における糖鎖機能の解析
2001 - 2001 改良遺伝子トラップ法による新規発生制御遺伝子の単離と機能解析
2000 - 2000 糖転移酵素遺伝子欠損マウスを用いた発癌・転移における糖鎖機能の解析
2000 - 2000 ガラクトース転移酵素遺伝子ノックアウトマウスを用いた糖鎖機能の解析
1999 - 2000 A trial to generate recipient mice which support the development of human hematopoietic stem cells to T-lymphocytes
1998 - 2000 Functional analysis of IL-1 in immune and stress responses using gene knockout mice
1998 - 2000 Development of rheumatoid arthritis models using transgenic technique
2000 - 発生工学的手法を用いたヒト疾患モデル動物の開発
2000 - Development of animal model for human disease using embryo manipulating technology
1993 - Functional analysis of carbohydrates using glycosyltransferase knockout mice
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Papers (160)：
Kohtaro Morita, Arata Honda, Masahide Asano. A Simple and Efficient Method for Generating KO Rats Using In Vitro Fertilized Oocytes. Methods in Molecular Biology. 2023. 233-246
Heng Wei, Chie Naruse, Daisuke Takakura, Kazushi Sugihara, Xuchi Pan, Aki Ikeda, Nana Kawasaki, Masahide Asano. Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice. Frontiers in immunology. 2023. 14. 1272537-1272537
魏 恒, 成瀬 智恵, 川崎 ナナ, 浅野 雅秀. ガラクトース転移酵素欠損マウスは高免疫原性腫瘍の増殖を抑制する(Galactosyltransferase-deficiency suppresses the growth of immunogenic tumors in mice). 日本癌学会総会記事. 2022. 81回. P-3009
Chie Naruse, Kazushi Sugihara, Tatsuhiko Miyazaki, Xuchi Pan, Fumihiro Sugiyama, Masahide Asano. A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice. NAR cancer. 2022. 4. 2. zcac019
Momoe Sukegawa, Toru Yoshihara, Shengqun Hou, Masahide Asano, Anthony J Hannan, Dan Ohtan Wang. Long-lasting housing environment manipulation and acute loss of environmental enrichment impact BALB/c mice behaviour in multiple functional domains. The European journal of neuroscience. 2022. 55. 5. 1118-1140
Masahide Asano. Galactose-containing carbohydrates in the inflammation, development and nervous system. Seikagaku. 2014. 86. 3. 382-390
Cui Hong, Okamoto Yasuo, Yoshioka Kazuaki, Du Wa, Takuwa Noriko, Zhang Wei, Biswas Kuntal, Aki Sho, Zhao JuanJuan, Kuda Yuichi, et al. Sphingosine-1-phosphate receptor-2 plays a protective role against anaphylactic shock through inhibiting eNOS. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S119
Chi-Bun Chan, Michiyo Abe, Noriyoshi Hashimoto, Chunhai Hao, Ifor R. Williams, Xia Liu, Shinji Nakao, Akitsugu Yamamoto, Chengyun Zheng, Jan-Inge Henter, et al. Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome (vol 106, pg 468, 2008). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009. 106. 14. 6023-6023
Analysis of IgA nephropathy development in b4-galactosyltransferase KO mice
2005 -
Quality of water produced by super pure water maker
2005 -
Education (3)：
1985 - 1988 京都大学大学院 理学研究科博士後期課程 化学
1983 - 1985 京都大学大学院 理学研究科博士前期課程 化学
1979 - 1983 Kyoto University Faculty of Science
Professional career (2)：
Doctor of Science (Kyoto University)
Master of Science (Kyoto University)
Work history (8)：
2014/12 - 現在 Kyoto University
2003/04 - 2014/11 Kanazawa University
2008/04 - 2014/06 Kanazawa University
2000/01 - 2003/03 Kanazawa University
1999/05 - 1999/12 The University of Tokyo The Institute of Medical Science
1993/04 - 1999/04 The University of Tokyo The Institute of Medical Science
1991/04 - 1993/03 マックスプランク生物物理化学研究所 博士研究員
1988/04 - 1991/03 Osaka Bioscience Institute
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Committee career (7)：
2018 - 現在 日本実験動物学会 理事
2016 - 2017 日本実験動物学会 評議員
2010 - 2015 日本実験動物学会 理事
2012 - 2013 国立大学法人動物実験施設協議会 会長
2010 - 2011 国立大学法人動物実験施設協議会 副会長
2002 - 2007 日本実験動物学会 評議員
2004 - 2005 国立大学法人動物実験施設協議会 副会長
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Awards (5)：
2019/05 - 日本実験動物学会 安東・田嶋賞
2004 - 水谷糖質科学振興財団第11回研究助成
2002 - 第8回日本ニ分脊椎・水頭症研究振興財団研究助成金
2000 - 平成12年度稲盛財団助成金
2000 - 平成12年度持田記念研究奨励賞
Association Membership(s) (9)：
日本エピジェネティクス研究会
, 日本生化学会
, 日本分子生物学会
, 日本実験動物学会
, Japanese Society of Epigenetics
, The Japanese Biochemical Society
, The Molecular Biology Society of Japan
, Japanese Association for Laboratory Animal Science
, 関西実験動物研究会
