2016 - 2019 Development of novel antidepressants targetting lysophosphatidic-acid-signaling
2015 - 2017 Quantitative analysis of lysophosphatidic acid (LPA) in serum and cerebrospinal fluid of depressed patients
2014 - 2017 Investigation of the mechanisms on the emotional behaviors in mice via delta opioid receptors in prelimbic prefrontal cortex
2014 - 2017 Lysophosphatidic acid induces anxiety-like behavior via its receptors in mice
2013 - 2016 Development of a new suicide education program for social work students in Japan
2013 - 2016 A study on the therapeutic mechanisms of depression through a transcription factor MATH2 and its target gene Prg1.
2010 - 2012 Gene expression analysis in ventral and dorsal hippocampal dentate gyrus after 4 weeks treatment with sertraline
2010 - 2012 Prg1, regulated by MATH2, is an important factor for survival of neurons derived from neural stem cells
2008 - 2010 The investigation to Dynamin-1 for new antidepressats binding protein
2007 - 2009 An antidepressant related transcription factor Math2 regulates Prg1 expression and induces neurite differentiation.
2007 - 2008 The guide for points and issues of clinical trial with high-risk persons in suicidality
2006 - 2007 SCREENING FOR ANTIDEPRESSANT RELATED GENES RELATED TO NEUROGENESIS
2006 - 2007 The cloning and investigations for antidepressants affected protein with new chemical proteomics approach
2005 - 2006 THE EXPRESSION AND FUNCTION OF NOVEL GENE WITH RING H2 FINGER MOTIF IN VITRO AND IN VIVO.
2004 - 2006 Synthetic research on the actual condition of oral environment and function in mental disorder.
2004 - 2005 THE EXPRESSION OF SYNAPTIC VESICLE PROTEINS AFTER CHRONIC ANTIDEPRESSANT TREATMENT IN RAT BRAIN.
2002 - 2004 治療抵抗性うつ病の病態背景にあるヒト遺伝子多型の系統的探索
2002 - 2003 THE STUDY OF THE THERAPEUTIC MECHANISMS OF ANTIDEPRESSANT ON NEURONAL REMODELING
2001 - 2003 THE INVESTIGATION OF THE THERAPEUTIC MECHANISMS OF ANTIDEPRESSANT ON NEUROTRANSMITTER RELEASE
2000 - 2001 Ring fingerモチーフを有する新規遺伝子SRG34の分子生物学的研究
1999 - 2001 The study for molecular mechanisms of antidepressant.
Kazuya Okamura, Takashi Komori, Mai Sugimoto, Yoshitaka Kawashima, Mitsuhiko Yamada, Toshifumi Kishimoto. Implementation of evidence-based intervention for suicidal patients admitted to the emergency department: Implications from our real-world experience of assertive case management. Psychiatry and clinical neurosciences. 2021. 75. 3. 108-109
Hiroshi Kuniishi, Masayuki Sekiguchi, Mitsuhiko Yamada. [The contribution of orbitofrontal cortex to stress-related psychiatric disorders: stress induced synaptic change in the orbitofrontal-basolateral amygdala pathway]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2021. 156. 2. 62-65
Okito Hashimoto, Hiroshi Kuniishi, Yuko Nakatake, Mitsuhiko Yamada, Keiji Wada, Masayuki Sekiguchi. Early life stress from allergic dermatitis causes depressive-like behaviors in adolescent male mice through neuroinflammatory priming. Brain, behavior, and immunity. 2020. 90. 319-331