Rchr
J-GLOBAL ID：200901083002301815
Update date: Apr. 04, 2024
Masuda Takeshi
Masuda Takeshi | Masuda Takeshi
Affiliation and department：
Job title：
Project Lecturer
Research field (1)：
Genomics
Research keywords (4)：
Single-cell
, 多発性骨髄腫
, 鎌状赤血球
, プロテオミクス
Research theme for competitive and other funds (22)：
- 2022 - 2026 Elucidation of the mechanism of AML progression through a genomic structure-dependent regulation of transcriptional elongation
- 2022 - 2025 1つの核に存在するタンパク質を 網羅的に定量する技術の確立
- 2022 - 2025 ハイスループット1細胞プロテオミクスシステムの開発
- 2020 - 2025 Development of novel therapeutic strategies for therapy-refractory leukemia
- 2022 - 2024 tRNA修飾異常を起点とした赤血球プロテオスタシスの破綻
- 2021 - 2024 New molecular mechanisms for membrane-mediated transcellular transport across the blood brain barrier
- 2022 - 2024 Development of highly sensitive quantitative proteomics for cross biology
- 2021 - 2024 高分解能な空間プロテオミクス技術の開発
- 2021 - 2022 油中液滴法を基盤とした1細胞プロテオミクス技術の開発
- 2020 - 2022 Development of Single-cell proteomics system based on water-in oil method
- 2019 - 2022 油中液滴チャンバー法が可能にする1細胞プロテオミクスの開発
- 2020 - 2021 Identifying molecular mechanisms underlying treatment-refractory leukemia and their targeting strategies
- 2020 - 2021 Water droplet in oil-aided single cell proteomics
- 2018 - 2021 Mcrotransport of the blood-brain barrier and its application to the permeable carrier.
- 2017 - 2019 1 細胞プロテオミクスシステムの開発と鎌状赤血球症の治療標的候補の探索
- 2016 - 2019 Regulation mechanism of cell senescence by orphan transporter
- 2017 - 2018 偽装カシミヤ製品根絶に向けた高精度かつ簡易的な獣毛繊維鑑別システムの開発
- 2017 - 造血幹細胞の増幅効率を飛躍的に向上させるin vivo-mimic 培養ディッシュの開発と自己複製機構の 包括的理解
- 2013 - 翻訳後修飾依存的な時空間変動解析法の開発 -細胞間接着機構解明への応用-
- 2011 - 2012 代謝制御機構解明のための網羅的酵素定量法
- 2011 - 2012 高感度細胞表面抗原マーカー検出に向けたエピトープ領域の網羅的同定
- 2009 - 2011 プロテインキナーゼのインタラクトーム解析
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Papers (73)：
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Shingo Ito, Ryotaro Yagi, Seiryo Ogata, Takeshi Masuda, Takashi Saito, Takaomi Saido, Sumio Ohtsuki. Proteomic alterations in the brain and blood-brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer's disease. Fluids and barriers of the CNS. 2023. 20. 1. 66-66
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Yu Sakurai, Asa Ohtani, Yuka Nakayama, Masaki Gomi, Takeshi Masuda, Sumio Ohtsuki, Hiroki Tanaka, Hidetaka Akita. Logistics and distribution of small extracellular vesicles from the subcutaneous space to the lymphatic system. Journal of Controlled Release. 2023. 361. 77-86
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Yudai Hamada, Seiryo Ogata, Takeshi Masuda, Shingo Ito, Sumio Ohtsuki. Development of a method for isolating brain capillaries from a single neonatal mouse brain and comparison of proteomic profiles between neonatal and adult brain capillaries. Fluids and barriers of the CNS. 2023. 20. 1. 50-50
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Ryotaro Yagi, Takeshi Masuda, Shingo Ito, Sumio Ohtsuki. Effect of antibiotic-administration period on hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries. Drug metabolism and pharmacokinetics. 2023. 50. 100494-100494
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Nakao F, Setoguchi K, Semba Y, Yamauchi T, Nogami J, Sasaki K, Imanaga H, Terasaki T, Miyazaki M, Shigeki Hirabayashi, et al. Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance. Leukemia. 2023
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MISC (8)：
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増田 豪. 質量分析を使った1細胞プロテオミクス技術. Journal of Mass Spectrometry Society of Japan. 2023. 71. 3. 134-135
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増田豪, 大槻純男. 次世代プロテオミクス技術の開発と展開. Dojin news. 2023. 186. 8-11
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1細胞プロテオミクスの現在. THE CELL. 2023. 55. 7. 71-74
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増田 豪. 1細胞プロテオミクス技術の最前線. ファルマシア. 2022. 58. 6. 577-581
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Takeshi Masuda. Trends in Single-Cell Proteomics Technology. Journal of the Mass Spectrometry Society of Japan. 2022. 70. 1. 72-73
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Patents (6)：
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Animal Hair Fiber Identification Method
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獣毛繊維の鑑別方法
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エチレングリコール及び界面活性剤を含む溶液を用いた細胞分画法
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タンパク質試料の調製方法
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豚浮腫病のスクリーニング方法
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Lectures and oral presentations (167)：
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High-throughput single-cell proteomics based on water droplet-in-oil digestion method
(HUPO 2023 World Congress 2023)
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Proteomics evaluation of isolated neonatal brain capillaries and developmental changes in the blood-brain barrier proteins in mice.
(2023)
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Water droplet in oil digestion method-aided high-throughput single-cell proteomics
(2023)
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Deep proteomic analysis of species differences in the blood-brain barrier between mice and humans
(2023)
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It's time for Single-cell proteomics
(2023)
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Education (2)：
- 2002 - 2004 Tokyo University of Agriculture Graduate School of Bio-industry Department of Bio-industry
- 1998 - 2002 Tokyo University of Agriculture Faculty of Bio-industry Department of Bio-production
Professional career (1)：
- 生物産業学 (東京農業大学大学院生物産業学研究科)
Work history (6)：
Committee career (1)：
- 2021/04 - 現在 日本プロテオーム学会 理事
Awards (5)：
- 2015 - The American Society of Hematology ASH Abstract Achievement Award
- 2012 - 日本プロテオーム学会 奨励賞
- 2011 - 2011 JHUPO Best Poster Award
- 2008 - 2008年度BMSトラベルアワード
- 2008 - BMS travel award
Association Membership(s) (3)：
日本質量分析学会
, 日本生化学会
, 日本プロテオーム学会
