Rchr
J-GLOBAL ID：200901083915352120
Update date: Oct. 05, 2024
Keiji Miyazawa
ミヤザワ ケイジ | Keiji Miyazawa
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.med.yamanashi.ac.jp/basic/bioche02/bioch2.html
Research field (5)：
Pharmaceuticals - health and biochemistry
, Tumor biology
, Pathobiochemistry
, Medical biochemistry
, Functional biochemistry
Research theme for competitive and other funds (23)：
- 2021 - 2025 EMT関連形質を個別に誘導するTGF-βシグナル分岐経路の解析
- 2020 - 2023 Comprehensive Studies on the Mechanisms of Cancer Metastasis from Molecular Signaling to Whole-Body Level
- 2017 - 2020 Smad転写複合体のheterogeneityを識別する手法の開発
- 2016 - 2019 がん悪性化に関与するSmad cofactorの同定と機能解析
- 2011 - 2014 Studies on a role of TGF-beta mimetic activity of HCV NS3 protease in pathogenesis of liver cirrhosis
- 2010 - 2013 TGF-βシグナルの細胞応答選択的な制御手法の研究
- 2005 - 2009 Establishment of New Strategies for Treatment of Cancer Using TGF-beta Signaling
- 2005 - 2006 Molecular basis of the signaling networks that regulate vasculogenesis
- 2002 - 2005 Study on cell biological activities of serine-threonine kinase receptors
- 2003 - 2004 Molecular mechanism of vascular endothelial/mural cell differentiation by receptor tyrosine kinases
- 2000 - 2004 Mechanisms of TGF-β signaling and its abnormalities in human cancer
- 2002 - 2002 細胞増殖因子刺激による増殖促進・抑制のスイッチング機構に関する研究
- 2001 - 2002 Regulation of HAM function by proteolytic processing
- 1999 - 2000 Use of hepatocyte growth factor activator for limited digestion of tagged fusion proteins
- 1999 - 1999 細胞増殖制御の新しいシグナル伝達経路に関わる蛋白質の立体構造の解明
- 1999 - 1999 細胞増殖因子と受容体の細胞内分解の分子機構
- 1998 - 1999 Mechanism of ligand : receptor complex assembly of platelet-derived growth factor (PDGF)
- 1998 - 1998 細胞増殖制御の新しいシグナル伝達径路に関わる蛋白質の立体構造の解明
- 1998 - 1998 細胞増殖因子と受容体の細胞内分解の分子機構
- 1994 - 1994 肝細胞増殖因子活性化活性化酵素(HGFactivator)の肝障害時の機能に関する研究
- 1993 - 1994 Structural and functional characterization of a novel serine protease responsible for activation of hepatocyte growth factor
- 1993 - 1993 障害肝における肝細胞増殖因子の活性化機構に関する研究
- 1990 - 1990 肝癌および肝障害における肝細胞増殖因子の遺伝子発現調節機構の解析
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Papers (133)：
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Arisa Kinouchi, Takahiro Jubashi, Rikito Tatsuno, Jiro Ichikawa, Kaname Sakamoto, Daiju Sakurai, Tomonori Kawasaki, Hiroki Ishii, Keiji Miyazawa, Masao Saitoh. Roles of ZEB1 and ZEB2 in E-cadherin expression and cell aggressiveness in head and neck cancer. Genes to cells : devoted to molecular & cellular mechanisms. 2024
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Jeong-Hwan Yoon, Eunjin Bae, Yasuo Nagafuchi, Katsuko Sudo, Jin Soo Han, Seok Hee Park, Susumu Nakae, Tadashi Yamashita, Ji Hyeon Ju, Isao Matsumoto, et al. Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation. Life science alliance. 2024. 7. 9
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Yuka Itoh, Kunio Miyake, Daizo Koinuma, Chiho Omata, Masao Saitoh, Keiji Miyazawa. Analysis of the DNA-binding properties of TGF-β-activated Smad complexes unveils a possible molecular basis for cellular context-dependent signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024. 38. 15. e23877
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Motizuki M, Yokoyama T, Saitoh M, Miyazawa K. The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation. 2024. 300. 1. 105580
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Itoh Y, Sawaguchi T, Fu H, Omata C, Saitoh M, Miyazawa K. Indole-derived compound SIS3 targets a subset of activated Smad complexes. JOURNAL OF BIOCHEMISTRY. 2023. 173. 283-291
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MISC (16)：
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Miyazawa K, Itoh Y, Fu H, Miyazono K. Receptor-activated transcription factors and beyond: multiple modes of Smad2/3-dependent transmission of TGF-β signaling. JOURNAL OF BIOLOGICAL CHEMISTRY. 2024. 300. 107256
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Yan X, Zhang L, Miyazawa K, Ten Dijke P. TGF- β and BMP signaling in cancer. Frontiers in Cell and Developmental Biology. 2022. 10. 1012326
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Yuka Itoh, Masao Saitoh, Keiji Miyazawa. Smad3-STAT3 crosstalk in pathophysiological contexts. Acta Biochimica et Biophysica Sinica. 2018. 50. 1. 82-90
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Keiji Miyazawa, Kohei Miyazono. Regulation of TGF-beta Family Signaling by Inhibitory Smads. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2017. 9. 3. a022095
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Akira Hayakawa, Masao Saitoh, Keiji Miyazawa. Dual roles for epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) in cancer progression. Advances in Experimental Medicine and Biology. 2017. 925. 33-40
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Books (19)：
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臨床生化学(第7版)
メディカ出版 2024 ISBN:9784840481557
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分子細胞生物学(第9版)
2023
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薬と生命を学人のための基礎生化学
化学同人 2023 ISBN:9784759821666
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臨床生化学(第6版)
メディカ出版 2023 ISBN:9784840478328
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ミースフェルド 生化学
東京化学同人 2020
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Education (2)：
- - 1988 The University of Tokyo 薬学系研究科
- - 1983 The University of Tokyo 薬学部 薬学科
Professional career (1)：
Work history (7)：
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