TAKASHI MIKI

Affiliation and department：
Job title： Professor

Research keywords (3)： insulin , obesity , Diabetes mellitus

Research theme for competitive and other funds (22)：

2022 - 2026 構造特異的胆汁酸シグナルによる新規脂肪肝抑制機構のマルチオミクス解析
2020 - 2023 Pathophysiological roles of cell senescence related gene in the polycystic kidney disease
2019 - 2022 Mechanism of proliferation, differentiation, and dedifferentiation of pancreatic beta-cells induced by local signals
2019 - 2022 Roles of KATP channels on the regulation of heat production and metabolism in adipose tissues
2016 - 2019 Mechanism of repetitive proliferation and plasticity acquisition of pancreatic beta cells: prerequisites for the maintenance of glucose homeostasis

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Papers (117)：

Ryo Hatano, Eunyoung Lee, Hiromi Sato, Masahiro Kiuchi, Kiyoshi Hirahara, Yoshimi Nakagawa, Hitoshi Shimano, Toshinori Nakayama, Tomoaki Tanaka, Takashi Miki. Hepatic ketone body regulation of renal gluconeogenesis. Molecular Metabolism. 2024. 101934-101934
Ikki Sakuma, Hidekazu Nagano, Naoko Hashimoto, Masanori Fujimoto, Akitoshi Nakayama, Takahiro Fuchigami, Yuki Taki, Tatsuma Matsuda, Hiroyuki Akamine, Satomi Kono, et al. Identification of genotype-biochemical phenotype correlations associated with fructose 1,6-bisphosphatase deficiency. Communications biology. 2023. 6. 1. 787-787
Hanna Deguchi-Horiuchi, Sawako Suzuki, Eun Young Lee, Takashi Miki, Noriko Yamanaka, Ichiro Manabe, Tomoaki Tanaka, Koutaro Yokote. Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia. Scientific reports. 2023. 13. 1. 7291-7291
Masanori Fujimoto, Masataka Yokoyama, Masahiro Kiuchi, Hiroyuki Hosokawa, Akitoshi Nakayama, Naoko Hashimoto, Ikki Sakuma, Hidekazu Nagano, Kazuyuki Yamagata, Fujimi Kudo, et al. Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis. Nature communications. 2022. 13. 1. 5408-5408
Carol Prives, Sawako Suzuki, Divya Venkatesh, Hiroaki Kanda, Akitoshi Nakayama, Hiroyuki Hosokawa, Eunyoung Lee, Takashi Miki, Brent R Stockwell, Koutaro Yokote, et al. GLS2 is a tumor suppressor and a regulator of ferroptosis in hepatocellular carcinoma. Cancer research. 2022. 82. 18. 3209-3222

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MISC (93)：

鈴木佐和子, 出口ハンナ, 李恩瑛, 三木隆司, 田中知明, 横手幸太郎. 栄養素(ブドウ糖,アミノ酸,脂質)の代謝と肝疾患と糖尿病 Glutaminolysisの肝臓・膵臓臓器間ネットワークを介した役割解明. 糖尿病. 2021. 64. Suppl.1. LD-4
出口ハンナ, 鈴木佐和子, 石渡一樹, 内藤久美子, 山中典子, 真鍋一郎, 李恩瑛, 三木隆司, 龍野一郎, 田中知明, et al. グルタミン代謝の破綻による糖尿病発症とその分子メカニズム解明. 肥満研究. 2019. 25. Suppl. 252-252
鈴木佐和子, 出口ハンナ, 石渡一樹, 内藤久美子, 藤本真徳, 李恩瑛, 三木隆司, 神田浩明, 龍野一郎, 小出尚史, et al. グルタミン代謝遺伝子Glutaminase2が癌と生活習慣病に及ぼす影響. 肥満研究. 2019. 25. Suppl. 264-264
E. Lee, M. Morimoto, T. Miki. Mechanism for anti-diabetic action of eicosapentaenoic acid in the high-fat diet-sensitive diabetes mouse model. DIABETOLOGIA. 2016. 59. S280-S281
鈴木佐和子, 中山哲俊, 李恩瑛, 三木隆司, 田中知明, 横手幸太郎. 生活習慣病と癌の共通の分子基盤としてのGLS2の役割の解明. 日本内分泌学会雑誌. 2016. 92. 1. 261-261

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Education (2)：

1993 - 1997 Chiba University Graduate School of Medicine
1982 - 1988 Chiba University Medical School

Professional career (1)：

博士(医学)(千葉大学)

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