Takahashi Masaharu

タカハシマサハル | Takahashi Masaharu

Affiliation and department：

Research field (2)： Immunology , Virology

Research keywords (2)：肝炎ウイルス , Viral Hepatitis

Research theme for competitive and other funds (11)：

2013 - 2015 Research on mechanism of hepatitis E virus egress utilizing membrane traffic
2011 - 2012 Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles
2010 - 2012 Characterization of cell culture-generated hepatitis E virus particles:evaluation of neutralizing antibodies-inducing ability as the material of inactivated vaccineproduction
2010 - 2012 Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEV
2007 - 2008 Characterization of hepatitis E virus (HEV) particles and analysis of replication mechanism by using a cell culture system for HEV

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Papers (205)：

Shigeo Nagashima, Putu Prathiwi Primadharsini, Takashi Nishiyama, Masaharu Takahashi, Kazumoto Murata, Hiroaki Okamoto. Development of a HiBiT-tagged reporter hepatitis E virus and its utility as an antiviral drug screening platform. JOURNAL OF VIROLOGY. 2023
Masaharu Takahashi, Satoshi Kunita, Tsutomu Nishizawa, Hiroshi Ohnishi, Putu Prathiwi Primadharsini, Shigeo Nagashima, Kazumoto Murata, Hiroaki Okamoto. Infection Dynamics and Genomic Mutations of Hepatitis E Virus in Naturally Infected Pigs on a Farrow-to-Finish Farm in Japan: A Survey from 2012 to 2021. VIRUSES-BASEL. 2023. 15. 7
Putu Prathiwi Primadharsini, Shigeo Nagashima, Toshinori Tanaka, Suljid Jirintai, Masaharu Takahashi, Kazumoto Murata, Hiroaki Okamoto. Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA Clone. VIRUSES-BASEL. 2023. 15. 4
Satoshi Takakusagi, Hitoshi Takagi, Yuichi Yamazaki, Takashi Kosone, Shigeo Nagashima, Masaharu Takahashi, Kazumoto Murata, Hiroaki Okamoto. Chronic hepatitis E in an elderly immunocompetent patient who achieved a sustained virologic response with ribavirin treatment. Clinical journal of gastroenterology. 2023. 16. 2. 206-215
Putu Prathiwi Primadharsini, Shigeo Nagashima, Masaharu Takahashi, Kazumoto Murata, Hiroaki Okamoto. Ritonavir Blocks Hepatitis E Virus Internalization and Clears Hepatitis E Virus In Vitro with Ribavirin. VIRUSES-BASEL. 2022. 14. 11

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MISC (20)：

長嶋茂雄, プリマダルシニプトゥプラティウィ, 西山尚志, 高橋雅春, 村田一素, 岡本宏明. 発光タグHiBiTを保有する組換えE型肝炎ウイルスの開発と薬剤スクリーニングへの応用. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2022. 69th
Yuichi Yamazaki, Takashi Ueno, Takeshi Hatanaka, Satoshi Takakusagi, Daichi Takizawa, Atsushi Naganuma, Takashi Kosone, Hiroaki Nakajima, Ken Sato, Satoru Kakizaki, et al. Characteristics of cases of hepatitis E in Gunma prefecture: Small epidemics caused by the same subgenotype 3a strains. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2021. 36. 87-88
小林富成, 高橋雅春, 長嶋茂雄, 西山尚志, PRIMADHARSINI Putu Prathiwi, 西澤勉, 岡本宏明. E型肝炎ワクチン開発に向けた大腸菌でのHEV(3型と4型)ORF2蛋白質の産生とウイルス様粒子の構築. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2019. 67th
プリマダルシニプトゥプラティウィ, 長嶋茂雄, 小林富成, 高橋雅春, 安田二朗, 岡本宏明. ラットE型肝炎ウイルスの感染細胞からの放出にはMVB sortingならびにエクソソーム分泌経路が重要である. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2019. 67th
大和田洋平, 大城幸雄, 稲垣勇紀, 高橋一広, 湯沢賢治, 大西浩史, 長嶋茂雄, 高橋雅春, 岡本宏明, 大河内信弘. わが国における心・腎移植患者のE型肝炎ウイルス感染の全国実態調査最終報告. 移植. 2018. 53. 総会臨時. 454-454

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Education (4)：

- 1985 Iwate University Graduate School of Agriculture
- 1985 Iwate University Graduate School, Division of Agriculture
- 1983 Iwate University Faculty of Agriculture
- 1983 Iwate University Faculty of Agriculture

Professional career (2)：

(BLANK) (Iwate University)
博士(医学) (自治医科大学(JMU))

Work history (7)：

2000 - 2003 Jichi Medical University School of Medicine
2000 - 2003 Reseach Associate, Jichi Medical School
2003 - - 自治医科大学医学部学内講師
2003 - - Lecturer, Jichi Medical School
1985 - 1999 (株)特殊免疫研究所研究員

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