J-GLOBAL ID:200901085108578436   Update date: Nov. 26, 2019


マチダ タクジ | MACHIDA Takuji
Affiliation and department:
Job title: Assistant Professor
Research field  (3): Cell biology ,  Pharmacology in pharmacy ,  General pharmacology
Research keywords  (4): Vascular Smooth Muscle Cells ,  Docosahexaenotic Acid ,  Inducible Nitiric Oxide Synthase ,  Cyclooxygenase
Research theme for competitive and other funds  (1):
  • Specific modulation of vascular smooth muscle cell functions by docosahexaenoic acid.
Papers (19):
  • Takano Y, Hirano M, Machida T, Obara Y, Hamaue N, Fujita K, Taniguchi M, Endo T, Shiga S, Machida M, Iizuka K, Hirafuji M. Nitric oxide plays a critical role in methotrexate-induced hyperplasia of enterochromaffin cells containing 5-hydroxytryptamine in rat small intestine. Journal of pharmacological sciences. 2019. 141. 1. 32-40
  • Machida M, Shiga S, Machida T, Ohno M, Iizuka K, Hirafuji M. Potentiation of Glucagon-Like Peptide-2 Dynamics by Methotrexate Administration in Rat Small Intestine. Biological & pharmaceutical bulletin. 2019. 42. 10. 1733-1740
  • Obara Y, Machida T, Takano Y, Shiga S, Suzuki A, Hamaue N, Iizuka K, Hirafuji M. Cisplatin increases the number of enterochromaffin cells containing substance P in rat intestine. Naunyn-Schmiedeberg's archives of pharmacology. 2018
  • Machida T, Yutani M, Goto A, Nishimura S, Kawamura A, Iizuka K, Hirafuji M. Docosahexaenoic acid suppresses angiotensin II-induced A7r5 vascular smooth muscle cell proliferation and migration under pulsatile pressure stress. Biomedical research (Tokyo, Japan). 2018. 39. 3. 141-148
  • Endo T, Samokhvalov V, Darwesh AM, Khey KMW, El-Sherbeni AA, Ei-Kadi AOS, Machida T, Hirafuji M, Seubert JM. DHA and 19,20-EDP induce lysosomal-proteolytic-dependent cytotoxicity through de novo ceramide production in H9c2 cells with a glycolytic profile. Cell death discovery. 2018. 5. 29
MISC (2):
Lectures and oral presentations  (143):
  • Mitogen-activated protein kinase-mediated cyclooxygenase-2 induction by 5-hydroxytryptamine in cultured rat vascular smooth muscle cells.
    (第75回日本薬理学会年会 2002)
  • Effect of sphingosine 1-phosphate on interleukin-1 -induced nitric oxide production by vascular smooth muscle cells.
  • Docosahexaenoic acid potentiates interleukin-1-induced nitric oxide synthase expression via p44/42 mitogen-activated protein kinase activation in vascular smooth muscle cells.
    (第75回日本薬理学会年会 2002)
  • ドコサヘキサエン酸は血管平滑筋細胞においてp44/42 MAPキナーゼの活性化を亢進してiNOS誘導を促進する
    (日本薬学会北海道支部第118回例会 2002)
  • Docosahexaenoic acid potentiates interleukin-1-induced nitric oxide production pathways in rat vascular smooth muscle cells.
    (第14回国際薬理学会 2002)
Education (2):
  • - 1999 Health Sciences University of Hokkaido Faculty of Pharmaceutical Science
  • - 2001 Health Sciences University of Hokkaido Graduate School, Division of Pharmaceutical Sciences Pharmacology
Professional career (1):
  • - (Health Sciences University of Hokkaido)
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