Rchr
J-GLOBAL ID:200901085254785796
Update date: Apr. 14, 2024
Mihara Hisaaki
ミハラ ヒサアキ | Mihara Hisaaki
Affiliation and department:
Job title:
Professor
Other affiliations (1):
Homepage URL (1):
https://mihalab2018.wixsite.com/mihalab
Research field (7):
Bioorganic chemistry
, Applied biochemistry
, Applied microbiology
, Functional biochemistry
, Structural biochemistry
, Applied biofunctional and bioprocess engineering
, Biochemistry
Research keywords (1):
enzyme, trace element, selenium, sulfur, selenoprotein, metal, microbe, chiral compound, bacteria, protein, cofactor, coenzyme, vitamin
Research theme for competitive and other funds (30):
- 2024 - 2027 細菌における元素状硫黄呼吸の分子メカニズム
- 2022 - 2024 セレンタンパク質の革新的生産プラットフォームの開発
- 2022 - 2024 微生物が駆動し、ヒトと環境を繋ぐセレノダイナミクス
- 2020 - 2023 Dynamics of selenium metabolisms and diversity of their molecular mechanisms in microbes
- 2018 - 2020 Development and application of expression system for active selenoproteins
- 2016 - 2019 Reactions specific to active selenium species in selenoprotein biosynthesis
- 2016 - 2018 Analysis of selenium metabolism utilizing high concentration selenium-resistant bacteria
- 2014 - 2016 Mechanism of metal nanoparticle synthesis in bacteria and its application to solar cells
- 2011 - 2016 Mechanism of selenium-specific chemical transformation in selenoprotein biosynthesis
- 2012 - 2015 Inner Mogolia, China
- 2012 - 2014 Bacterial synthesis of materials applicable to CIGS solar cells
- 2009 - 2010 Function of selenium-delivering proteins and regulation of selenium trafficking
- 2008 - 2010 Analysis of the molecular basis for cold adaptation of psychrotrophic bacteria
- 2007 - 2008 遷移金属クラスターとバイオ分子の複合化による新機軸機能性分子の創製
- 2007 - 2008 Exploration of novel cold-adapted microorganisms to develop a systemfor the production of useful compounds at low temperatures
- 2007 - 2008 Structure and function of selenium-specific chemical conversion system and co-translational insertion of selenium into proteins
- 2007 - 2007 多金属骨格の構造変化をベースとした新機軸触媒設計
- 2006 - 2007 必須微量元素セレン特異的原子認識機構とセレンタンパク質生合成装置の解明
- 2006 - 2007 Investigation of organisms having unique selenium metabolic pathways and its application to bioremediation
- 2005 - 2007 Conversion of Organofluorine Compounds with Microbial Enzymes : Mechanistic Analysis of the Enzyme Reactions and Their Application to Production of Useful Compounds and Bioremediation of Environments
- 2005 - 2006 Exploration of Novel Cold-adapted Microorganisms That Inhabit the Polar Regions and Investigation of Their Useful Enzymes
- 2005 - 2006 Dynamics of the essential trace element selenium in mammals and molecular basis for selenoprotein biosynthesis
- 2004 - 2005 封入体形成を抑制する低温タンパク質生産システムの開発
- 2003 - 2005 tRNAのアンチコドンゆらぎ塩基への硫黄・セレン挿入機構
- 2003 - 2004 Screening of novel cold-adapted microorganisms and exploitation of their useful gene resources
- 2003 - 2004 Analysis of the mechanism of activation and co-translational insertion of an essential trace element, selenium, into polypeptide
- 2002 - 2003 Studies of physiological function of D-aspartate in eukaryotic cells : from yeasts to mammals
- 2001 - 2002 鉄の輸送に関与するsuf遺伝子領域およびSufタンパク質群の機能解析
- 2001 - 2002 Whole-genome sequencing of a psychrophilic bacterium, analysis of genes involved in cold adaptation, and exploitation of cold-active enzymes
- 2001 - 2002 Dynamism of activated-selenium species: Structural biological analysis of mechanism of biosynthesis of selenium-containing proteins
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Papers (116):
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Atsuki Shimizu, Ryuta Tobe, Riku Aono, Masao Inoue, Satoru Hagita, Kaito Kiriyama, Yosuke Toyotake, Takuya Ogawa, Tatsuo Kurihara, Kei Goto, et al. Initial step of selenite reduction via thioredoxin for bacterial selenoprotein biosynthesis. International Journal of Molecular Sciences. 2021. 22. 20
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Masao Inoue, Yuu Hirose, Ryuta Tobe, Shigeki Saito, Riku Aono, N Tejo Prakash, Hisaaki Mihara. Complete Genome Sequence of Pseudomonas stutzeri Strain F2a, Isolated from Seleniferous Soil. Microbiology resource announcements. 2021. 10. 33. e0063121
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Yuu Hirose, Jakkaphan Kumsab, Ryuta Tobe, Hisaaki Mihara. Complete Genome Sequence of an Acetic Acid Bacterium, Acetobacter aceti JCM20276. Microbiology resource announcements. 2020. 9. 42
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Jakkaphan Kumsab, Ryuta Tobe, Tatsuo Kurihara, Yuu Hirose, Taketo Omori, Hisaaki Mihara. Characterization of a novel class of glyoxylate reductase belonging to the β-hydroxyacid dehydrogenase family in Acetobacter aceti. Bioscience, biotechnology, and biochemistry. 2020. 84. 11. 1-8
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戸部隆太, 三原久明. 必須微量元素セレンの生理作用と代謝 ~セレンタンパク質の機能とセレン代謝~. 化学と生物. 2019. 57. 6. 366-372
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MISC (7):
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青野陸, 井上真男, 三原久明. 必須微量元素セレンの微生物による多彩な代謝. ファルマシア. 2023. 59. 3. 185-189
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葛野侑香, 生田帆河, 西田亮, 戸部隆太, 広瀬侑, PRAKASH Tejo, 三原久明. Bacillus sp.NTP-1株における新規テルル酸還元酵素の同定とその機能解析. 日本農芸化学会大会講演要旨集(Web). 2018. 2018. ROMBUNNO.2A25p14 (WEB ONLY)
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桐山海斗, 清水敦貴, 片山碧, 戸部隆太, 広瀬侑, PRAKASH N. Tejo, 三原久明. セレン耐性菌Pseudomonas sp.F2a株のチオレドキシンシステムの解析. 日本微量栄養素学会学術集会講演要旨集. 2017. 34th. 7
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Suguru Kurokawa, Masanori Takehashi, Hiromitsu Tanaka, Hisaaki Mihara, Tatsuo Kurihara, Seigo Tanaka, Kristina Hill, Raymond Burk, Nobuyoshi Esaki. Mammalian Selenocysteine Lyase Is Involved in Selenoprotein Biosynthesis (vol 57, pg 298, 2011). JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY. 2015. 61. 6. 543-543
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Possible role of red blood cells in selenocysteine metabolism. Trace nutrients research. 2009. 26. 22-25
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Books (12):
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エッセンシャル タンパク質工学
講談社 2018
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Selenium in Plants
Springer 2017
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Selenium: Its Molecular Biology and Role in Human and Health 4th Ed.
Springer 2016
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地球を救うメタルバイオテクノロジー -微生物と金属資源のはなし-
成山堂書店 2014 ISBN:9784425800018
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Selenium in the Environment and Human Health
CRC Press, London 2014
more...
Lectures and oral presentations (215):
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Bacillus属細菌におけるテルル酸還元酵素の解析
(メタルバイオサイエンス研究会2018 2018)
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Cellulomonas sp. D3a 株の亜セレン酸還元機構の解析
(第6回メタロミクス研究フォーラム 2018)
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Pseudomonas putidaのD-リジン異化代謝オペロン転写制御因子の解析
(第454回ビタミンB研究協議会 2018)
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Purification and characterization of a putative rhodanese-like protein GSU2940 from Geobacter sulfurreducens
(The 7th International Selenium Conference (Se2018) 2018)
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Functional analysis of a novel porin-like protein, ExtI, from Geobacter sulfurreducens and its implication in selenite and tellurite reduction
(The 7th International Selenium Conference (Se2018) 2018)
more...
Education (3):
- - 1999 Kyoto University "Graduate School, Division of Agriculture" Agricultural Chemistry Major
- - 1995 Kyoto University "Graduate School, Division of Agriculture" Agricultural Chemistry Major
- - 1993 Kyoto Prefectural University Faculty of Agriculture Department of Agricultural Chemistry
Professional career (1):
- Ph.D. (Agriculture) (Kyoto University)
Work history (6):
Committee career (15):
- 2015/11 - 2021/10 日本ビタミン学会 代議員
- 2019/01 - 2020/12 日本生化学会 「生化学」誌企画委員
- 2018/04 - 2020/03 ビタミンB研究委員会 準委員
- 2015/11 - 2019/11 日本生化学会 代議員
- 2017/10 - 2019/09 日本生化学会近畿支部 庶務幹事
- 2018/04 - 日本生物高分子学会 理事
- 2018/04 - Advisory Board
- 2018/04 - 日本生化学会 JB編集委員会編集参与(Advisory Board)
- 2016/04 - 日本微量栄養素学会 監事
- 2014/10 - 日本生物高分子学会 評議員
- 2014/04 - メタロミクス研究フォーラム 評議員
- 2014/04 - 日本微量栄養素学会 評議員
- 2014/04 - 日本農芸化学会関西支部 参与
- 2014/04 - 日本生化学会 評議員
- 2013/05 - 滋賀バイオ産業推進機構 バイオ・プロジェクト創出サロン事業運営委員
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Awards (1):
Association Membership(s) (6):
日本生物高分子学会
, Japan Trace Nutrients Research Society
, Japan Society for Biomedica1 Research on Trace Elements
, THE VITAMIN SOCIETY OF JAPAN
, "Japan Society for Bioscience, Biotechnology, and Agrochemistry "
, The Japanese Biochemical Society
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