Rchr
J-GLOBAL ID:200901085421585753   Update date: Jan. 30, 2024

Shinkai Yoichi

シンカイ ヨウイチ | Shinkai Yoichi
Affiliation and department:
Job title: Chief Scientist
Homepage URL  (1): http://shinkai.riken.jp/
Research field  (5): Genetics ,  Genomics ,  Cell biology ,  Molecular biology ,  Functional biochemistry
Research keywords  (13): transcriptional regulation ,  heterochromatin ,  protein post-translational modification ,  epigenetics ,  クロマチン ,  染色体 ,  ヒストン ,  メチル化酵素 ,  Chromatin ,  Chromosome ,  Telomere ,  Histone ,  Methyltransferase
Research theme for competitive and other funds  (24):
  • 2022 - 2025 Elucidation of molecular mechanism of heterochromatin formation and maintenance
  • 2018 - 2023 Oviduct as the site of fertilization and early embryonic development: Verification of its physiological functions using genetically engineering hamster model for clinical application
  • 2018 - 2023 細胞分化にともなうクロマチンポテンシャルの変化とその分子基盤
  • 2018 - 2022 ヒストンH3K9メチル化修飾による転写抑制の包括的理解
  • 2013 - 2018 細胞移植治療に向けた細胞アイデンティティー制御
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Papers (122):
  • Tadahiro Shimazu, Rei Yoshimoto, Kaoru Kotoshiba, Takehiro Suzuki, Shogo Matoba, Michiko Hirose, Mai Akakabe, Yoshihiro Sohtome, Mikiko Sodeoka, Atsuo Ogura, et al. Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism. Genes & Development. 2023
  • Kei Fukuda, Takeshi Shimi, Chikako Shimura, Takao Ono, Takehiro Suzuki, Kenta Onoue, Satoko Okayama, Hisashi Miura, Ichiro Hiratani, Kazuho Ikeda, et al. Epigenetic plasticity safeguards heterochromatin configuration in mammals. Nucleic Acids Research. 2023
  • Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, et al. A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nature Communications. 2023. 14. 1. 23-23
  • Qi Fang, Yusuke Kimura, Tadahiro Shimazu, Takehiro Suzuki, Ayumi Yamada, Naoshi Dohmae, Shintaro Iwasaki, Yoichi Shinkai. Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors. Scientific reports. 2022. 12. 1. 4104-4104
  • Yoshihiro Sohtome, Tadahiro Shimazu, Yoichi Shinkai, Mikiko Sodeoka. Propargylic Se-adenosyl-l-selenomethionine: A Chemical Tool for Methylome Analysis. Accounts of Chemical Research. 2021. 54. 20. 3818-3827
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MISC (180):
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Education (3):
  • 1986 - 1990 Juntendo University Graduate School of Medicine Immunology
  • 1984 - 1986 Tsukuba University Master course Medical Science
  • 1980 - 1984 Yamagata University Faculty of Science Department of Biology
Professional career (2):
  • Doctor of Medicine (Juntendo University)
  • Master of Medical Science (University of Tsukuba)
Work history (11):
  • 2015/04 - 現在 RIKEN Cellular memory laboratory Chief Scientist
  • 2012/04 - 2015/03 RIKEN Cellular memory laboratory Chief Scientist
  • 2011/04 - 2012/03 RIKEN Cellular memory laboratory, Advanced Science Institute Visiting Chief Scientist
  • 2003/07 - 2012/03 Kyoto University Institute for Virus Research Professor
  • 1998/06 - 2003/06 Kyoto University Institute for Virus Research Associate Professor
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Association Membership(s) (3):
The Japanese Society for Epigenetics ,  日本生化学会 ,  日本分子生物学会
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