Hayashi Shin'ichi

ハヤシシンイチ | Hayashi Shin'ichi

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.med.tohoku.ac.jp/about/laboratory/075.html , https://www.med.tohoku.ac.jp/english/about/laboratory/075.html

Research field (3)： Metabolism and endocrinology , Molecular biology , Functional biochemistry

Research keywords (4)：子宮癌 , 乳癌 , エストロゲン , 核内受容体

Research theme for competitive and other funds (30)：

2017 - 2020 Novel therapeutic and preventive strategy of resveratrol treatment in triple negative breast cancer cells
2017 - 2020 Plasticity of driver-signals for proliferation and progression of breast cancer, and its relation with therapy-resistance.
2015 - 2018 Investigation of biomakers for membrane-associated estrogen receptor signaling pathway in breast cancer cells using selective nano-ligand
2014 - 2017 Plasticity of breast cancer, origin of hormonal therapy resistance and cancer stemness.
2011 - 2013 Flexibility of intracellular estrogen signaling pathway and mechanism of aromatase inhibitor-resistance

2008 - 2009 乳癌のホルモン療法の個別化

2007 - 2009 Molecular mechanism of difference of estrogen sensitivity and response to endocrine therapy in breast and endometrial cancers

2007 - 2009 Analysis of androgen actions in human breast carcinoma

2006 - 2008 Estrogen in human lung cancer-intratumoral hormone production and analysis of intracrine mechanisms-

2005 - 2007 Microenvironmental regulation of estrogen signals in breast cancer

2005 - 2007 Analysis of endometrial cancer development

2005 - 2007 Development of novel mass-screening methods by three-dimension microarray for endometrial cancer

2005 - 2006 The biological significance of sex-steroid metabolism and responsive genes in the endometrium and breast

2003 - 2005 Molecular analysis of etiological factors and malignant degrees for non-small cell lung cancer

2000 - 2004 がん関連遺伝子発現の個体差と宿主・環境要因に関する研究

2000 - 2004 Study on the protection against estrogen-dependent cancer

2002 - 2003 Expression and functional regulation of estrogen receptor in hormone-dependent cancer

1999 - 2001 Relationship between menopausal distress and serum estrogen, isoflavone and intake level of isoflavone

1998 - 2000 Expression and functional modulation of estrogen receptor α in human breast cancer

1998 - 2000 MOLECULAR MECHANISM OF GLUCOCORTICOID RECEPTOR REGULATION

1998 - 1999 Intracellular redox regulation on hormone-dependent proliferation of breast cancer

1996 - 1998 肺癌、ことに腺癌の組織型と遺伝子変化

1996 - 1996 Molecular studies on liver cancer dovelopment in humans

1995 - 1996 Reglation of expression of human TCDD receptor and its physiological function.

1995 - 1995 Molecular studies on liver cancer development in humans

1995 - 1995 遺伝子多型に基づく発がん感受性の解析

1993 - 1993 ヒトチトクロームP450遺伝子の多型と発癌剤代謝,発癌との関係

1992 - 1992 ヒトチトクロームP-450遺伝子の多型と発癌剤代謝,発癌との関係

1991 - 1991 ヒトP450IA1遺伝子多型と肺癌発生の関連性の分子生物学的研究

1987 - 1987 ビタミンD_3の活性化に関与する酵素系に関する研究

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Papers (164)：

Takako Sakamoto, Keiji Tanimoto, Hidetaka Eguchi, Shunta Sasaki, Kouki Tsuboi, Shin-ichi Hayashi, Sahoko Ichihara. Resveratrol exhibits diverse anti-cancer activities through epigenetic regulation of E-cadherin and p21 in triple-negative breast cancer cells. Breast Cancer. 2023
Tatsuyuki Gohno, Toru Hanamura, Masafumi Kurosumi, Hiroyuki Takei, Yuri Yamaguchi, Shin-Ichi Hayashi. One DNA Methylation Regulates CHIP Gene Expression of Human Breast Cancer and Predicts Recurrence. Anticancer research. 2022. 42. 2. 759-766
Haruhiko Shindo, Narumi Harada-Shoji, Akiko Ebata, Miku Sato, Tomoyoshi Soga, Minoru Miyashita, Hiroshi Tada, Masaaki Kawai, Shinkichi Kosaka, Koji Onuki, et al. Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer. Cancers. 2021. 13. 17
Masafumi Iida, Daichi Toyosawa, Misato Nakamura, Kouki Tsuboi, Emi Tokuda, Toshifumi Niwa, Takanori Ishida, Shin-ichi Hayashi. Decreased ER dependency after acquired resistance to CDK4/6 inhibitors. Breast Cancer. 2020. 27. 5. 963-972
Kouki Tsuboi, Chiyuki Uematsu, Yuri Yamaguchi, Toshifumi Niwa, Shin-ichi Hayashi. Tumor microenvironmental growth factors induce long-term estrogen deprivation resistance in breast cancer. Breast Cancer. 2019. 26. 6. 748-757

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MISC (151)：

Zhaorong Guo, Hiroshi Tada, Narufumi Kitamura, Yoh Hamada, Shin-ichi Hayashi, Noriaki Ohuchi, Kosuke Gonda, Takanori Ishida. Prognostic value of nuclear and non-nuclear estrogen receptor expression by immunohistochemistry with phosphor-integrated dots in hormone receptor-positive early breast cancer. CANCER RESEARCH. 2018. 78. 13
飯田雅史, 中村美紗都, 徳田恵美, 丹羽俊文, 石田孝宣, 林慎一. 新規バイオマーカーの臨床応用、予後予測因子・治療効果予測因子 CDK4/6阻害剤耐性機序の解明と次治療の基礎的検討. 日本乳癌学会総会プログラム抄録集. 2018. 26回. 302-302
飯田雅史, 坪井洸樹, 丹羽俊文, 石田孝宣, 大内憲明, 林慎一. 乳癌細胞株におけるホルモン療法耐性獲得前後でのIGF1R阻害剤の有用性の検討. 日本乳癌学会総会プログラム抄録集. 2017. 25回. 282-282
Mechanisms of hormonal therapy resistance. 2017. 261. 5. 453-456
樋口徹, 尾林紗弥香, 黒住献, 矢島玲奈, 時庭英彰, 佐藤亜矢子, 藤井孝明, 長岡りん, 高他大輔, 林慎一, et al. Aromatase阻害薬耐性機構としてのSteroid Sulfatase及びOrganic Anion Transporter Peptideの新規バイオマーカーとしての可能性. 乳癌基礎研究. 2017. 25. 51-55

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Books (14)：

「がん生物学イラストレイテッド」
羊土社 2011
みんなに役立つ乳癌の基礎と臨床
医薬ジャーナル社 2009
Reproductive Oncology
Research Sighpost 2007
Reproductive Oncology
Research Signpost 2007
予防医学事典
朝倉書店 2005

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Lectures and oral presentations (462)：

癌幹細胞性によるLuminal型乳癌の新たな個別化
(第20回日本乳癌学会学術総会 2012)
Androgenシグナル抑制によるAI剤耐性機構
(第20回日本乳癌学会学術総会 2012)
ホルモン療法耐性細胞と癌幹細胞性の検討
(第20回日本乳癌学会学術総会 2012)
ER遺伝子のPromoter Usage・エピゲノム制御とER陽性乳癌個別化
(第20回日本乳癌学会学術総会 2012)
アロマターゼ阻害剤耐性機序の多様性と治療戦略の基礎
(第20回日本乳癌学会学術総会 2012)

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Education (1)：

- 1981 Kyushu University Faculty of Science 生物学科

Professional career (1)：

Doctor of Science (Kyushu University)

Committee career (14)：

2006/09 - 現在日本癌学会評議員
2006/09 - 現在日本内分泌学会査読委員
2006/09 - 現在日本乳癌学会評議員
2006/09 - 現在日本ステロイドホルモン学会理事
2006/09 - 現在日本生殖内分泌学会評議員

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Association Membership(s) (10)：

日本分子疫学研究会(2006/09- 評議員) , ホルモンと癌研究会(2006/09- 評議員) , 日本生殖内分泌学会(2006/09- 評議員) , 日本ステロイドホルモン学会(2006/09- 理事) , 米国癌学会(2006/09-) , 日本乳癌学会(2006/09- 評議員) , 日本内分泌学会(2006/09- 査読委員) , 日本癌学会(2006/09- 評議員) , 日本生化学会(2006/09-) , 日本分子生物学会(2006/09-)

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