Rchr
J-GLOBAL ID：200901085474976100   Update date: Jan. 31, 2024

YAMADA MITSUHIKO

ヤマダ ミツヒコ | YAMADA MITSUHIKO
Affiliation and department：
Shinshu University School of Medicine Department of Molecular Pharmacology

About Shinshu University School of Medicine Department of Molecular Pharmacology


Job title： Professor
Research field  (6)： Clinical pharmacy ,  Fetal medicine/Pediatrics ,  Physiology ,  Neuroscience - general ,  Cardiology ,  Pharmacology
Research keywords  (13)： Drug develpment ,  Metanephrogenesis ,  pediatric Heart Failure ,  Circulatory Pharmacology ,  Intracellular Signal Transduction System ,  G protein-coupled receptor ,  Heart ,  Ion channels ,  Intracellular calcium metabolism ,  Activators ,  skeletal muscle ,  Intracellular signal transduction system ,  Pkarmacodynamics
Research theme for competitive and other funds  (47)：
  • 2023 - 心筋細胞AT1受容体に共役する信号伝達経路の発達依存的変化の意義と機序の解明
  • 2021 - Application of a beta-arrestin-biased agonist, TRV027 to pediatric heart failure
  • 2018 - 2021 Identification of factors promoting final differentiation of cardiac myocytes after birth
  • 2020 - βアレスチンバイアスAT1受容体アゴニストを用いた小児心不全治療法の開発
  • 2015 - 2019 Discovery of novel Nav1.7 inhibitors by using bioinformatics
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Papers (127)：
  • Yuki Tanaka, Shin Kadota, Jian Zhao, Hideki Kobayashi, Satomi Okano, Masaki Izumi, Yusuke Honda, Hajime Ichimura, Naoko Shiba, Takeshi Uemura, et al. Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin. Stem cell research & therapy. 2023. 14. 1. 240-240
  • KAWAGISHI Hiroyuki, YAMADA Mitsuhiko. Role of Cytokine Receptor gp130 in Functional Development of the Neonatal Mouse Heart. THE SHINSHU MEDICAL JOURNAL. 2022. 70. 6. 373-382
  • Takashi Murayama, Nagomi Kurebayashi, Takuro Numaga-Tomita, Takuya Kobayashi, Satoru Okazaki, Kyosuke Yamashiro, Tsutomu Nakada, Shuichi Mori, Ryosuke Ishida, Hiroyuki Kagechika, et al. A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery. The Journal of general physiology. 2022. 154. 12
  • Hiroyuki Kawagishi, Tsutomu Nakada, Takuro Numaga-Tomita, Maite Larrañaga, Ang Guo, Long-Sheng Song, Mitsuhiko Yamada. Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart. American Journal of Physiology-Heart and Circulatory Physiology. 2022
  • Hideaki Inazumi, Koichiro Kuwahara, Yasuaki Nakagawa, Yoshihiro Kuwabara, Takuro Numaga-Tomita, Toshihide Kashihara, Tsutomu Nakada, Nagomi Kurebayashi, Miku Oya, Miki Nonaka, et al. NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis. Circulation research. 2022. 130. 2. 234-248
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MISC (55)：
  • βアレスチンバイアスAT1受容体アゴニストは新しい乳幼児心不全治療薬の有力候補である。. 医学のあゆみ. 2021. 276. 12. 1137-1138
  • Toshihide Kashihara, Tsutomu Nakada, Mitsuhiko Yamada. Regulation of the basal activity of Ca(v)1.2 cardiac L-type Ca2+ channels by casein kinase 2 alpha 'beta. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 85P-85P
  • Toshihide Kashihara, Tsutomu Nakada, Simmon Gomi, Masamichi Hirose, Mitsuhiko Yamada. The molecular mechanism by which chronic and excessive beta(1)-adrenergic stimulation remodels ventricular excitation-contraction coupling. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S94-S94
  • Toshihide Kashihara, Tsutomu Nakada, Shimmon Gomi, Mitsuhiko Yamada. Regulation of the basal activity of Ca(v)1.2 cardiac L-type Ca2+ channel by casein kinase 2. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 77P-77P
  • Tsutomu Nakada, Flucher Bernhard, Xiaona Sheng, Toshihide Kashihara, Toshihide Shibazaki, Masamichi Hirose, Mitsuhiko Yamada. The junctional membrane-targeting motif in C-terminal of L-type calcium channel alpha(1c) subunits. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2011. 115. 112P-112P
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Books (2)：
  • 熱血 循環器学 洋學社 井上信孝編集
    洋學社 2019
  • 倉智 嘉久編:別冊・医学のあゆみイオンチャネル最前線update
    医歯薬出版株式会社,東京 2005
Lectures and oral presentations  (18)：
  • Postnatal loss of gp130 caused impaired cardiac contractility accompanied by inhibition of physiological proliferation of cardiomyocytes.
    (NIPS International Meeting on Cardiovascular Physiology 2020 2020)
  • Molecular mechanism underlying cardiac early afterdepolarization induced by IKr and IKs suppression.
    (The 11th Annual Meeting of Japanese Safety Pharmacology Society 2020)
  • 新生児マウスにおける、gp130受容体を介した心筋細胞の発達機構
    (筋生理の集い 2019)
  • A beta arrestin-bias AT1 receptor agonist improves the survival of neonatal knock-in mice bearing a human dilated cardiomyopathy mutation.
    (The 50th NIPS International Symposium. ‘MIRACLES’ in Cardiovascular Physiology 2019)
  • βアレスチンバイアスアンジオテンシン1型受容体アゴニストは、新生児マウス心臓において持続的な陽性変力作用を示す
    (第29回日本循環薬理学会 2019)
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Education (1)：
  • 1978 - 1984 Kobe University Faculty of Medicine School of Medicine
Professional career (1)：
  • MD
Work history (4)：
  • 2004/07/01 - Professor, Dept. Mol. Pharamacol. Shinshu Univ. Sch. Med.
  • 2002/06/01 - 2004/06/30 Associate Professor, Dept. Pharamacol. II, Osaka Univ. Grad. Sch. Med.
  • 1998/04/01 - 2002/05/31 Assitant Professor, Dept. Card. Physiol., National Cardiovasc. Ctr. Res. Inst.
  • 1994/04/01 - 1998/03/31 Assistant Professor, Dept. Pharmacol. II, Osaka Univ. Sch. Med.
Committee career (1)：
  • 日本薬理学会 代議員
Awards (2)：
  • 2005/10/07 - 第5回医科学応用研究財団助成による日本心電学会論文賞
  • 1993/01/15 - 財団法人循環器学研究振興財団内田賞
Association Membership(s) (8)：
Japanese Society of Pediatric Cardiology and Cardiac Surgery ,  Japanese Society of Pharmacology ,  ISHR ,  The American Physiological Society ,  Biophysical Society ,  The Japanese Society of Electrocardiology ,  Physiological Society of Japan ,  The Japanese Circulation Society
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