HIDETOSHI KASSAI

カッサイヒデトシ | HIDETOSHI KASSAI

Affiliation and department：
Job title： Chief
Homepage URL (1)： http://lar.cdbim.m.u-tokyo.ac.jp/

Research field (1)： Molecular biology

Research keywords (4)： Genetically engineered animal , moleculat genetics , 神経科学 , neuroscience

Research theme for competitive and other funds (10)：

2022 - 2024 自閉症における運動学習の障害と軽運動による相乗的改善効果に関わる神経機構の解明
2018 - 2022 Identification and analysis of novel mTOR-interacting protein
2015 - 2018 Analysis of mTOR signaling in central nervous systems
2011 - 2012 Genetic analysis of physiological function of Rac1 and Cdc42 in dendritic spines
2010 - 2012 Roles of mTOR in neuronal development, synaptic plasticity and learning and memory

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Papers (6)：

Sakai Y, Kassai H, Nakayama H, Fukaya M, Maeda T, Nakao K, Hashimoto K, Sakagami H, Kano M, Aiba A. Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells. Scientific reports. 2019. 9. 1. 2799
Naito R, Kassai H, Sakai Y, Schönherr S, Fukaya M, Schwarzer C, Sakagami H, Nakao K, Aiba A, Ferraguti F. New Features on the Expression and Trafficking of mGluR1 Splice Variants Exposed by Two Novel Mutant Mouse Lines. Frontiers in molecular neuroscience. 2018. 11. 439
Kassai Hidetoshi, Aiba Atsu. Developmental stage-specific activation of mTOR signaling in mouse cerebral cortex. Japanese Journal of Biological Psychiatry. 2015. 26. 2. 75-80
Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A. Selective Activation of mTORC1 Signaling Recapitulates Microcephaly, Tuberous Sclerosis, and Neurodegenerative Diseases. Cell Reports. 2014. 7. 5. 1626-1639
Hidetoshi Kassai, Yoshitaka Fukada. Farnesylation versus geranylgeranylation in G-protein-mediated light signaling. The Enzymes. 2011. 29. Protein Prenylation Part A. 125-145

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MISC (42)：

mTOR Signaling in Brain Functions and Diseases. 2012. 31. 12. 1355-1359
小島大輔, 葛西秀俊, 櫻井啓輔, 岡野俊行, 今井啓雄, 中尾和貴, 中谷敬, 七田芳則, 饗場篤, 深田吉孝. ファルネシル欠失トランスデューシンγサブユニットを発現する視細胞の光応答解析. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2008. 81回・31回. 2T15-9
Hidetoshi Kassai, Toshio Terashima, Masahiro Fukaya, Kazuki Nakao, Mizuho Sakahara, Masahiko Watanabe, Atsu Aiba. Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation. EUROPEAN JOURNAL OF NEUROSCIENCE. 2008. 28. 2. 257-267
Hidetoshi Kassai, Toshio Terashima, Masahiro Fukaya, Kazuki Nakao, Mizuho Sakahara, Masahiko Watanabe, Atsu Aiba. Rac1 is selectively required for midline crossing of commissural axons in the cerebral cortex. NEUROSCIENCE RESEARCH. 2008. 61. S90-S90
Toshihide Tabata, Daisuke Kawakami, Kouichi Hashimoto, Hidetoshi Kassai, Takayuki Yoshida, Yuki Hashimotodani, Bertil B. Fredholm, Yuko Sekino, Atsu Aiba, Masanobu Kano. G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells. JOURNAL OF PHYSIOLOGY-LONDON. 2007. 581. 2. 693-708

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Education (2)：

1999 - 2004 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
1995 - 1999 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry

Professional career (2)：

Association Membership(s) (2)：

日本分子生物学会 , 日本神経科学会

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