Rchr
J-GLOBAL ID:200901086223618596   Update date: Jan. 10, 2020

SAKAI Hiroyasu

サカイ ヒロヤス | SAKAI Hiroyasu
Affiliation and department:
Job title: Assistant Professor
Homepage URL  (1): https://polaris.hoshi.ac.jp/kyoshitsu/seitaiyakuri/BiomolecularPharmacology/index.html
Research field  (6): Pharmacology in pharmacy ,  Biological pharmacy ,  General pharmacology ,  Functional biochemistry ,  Biological pharmacy ,  General pharmacology
Research keywords  (9): Muscle atrophy ,  anti-cancer drugs ,  RhoA ,  microRNA (miRNA) ,  glucocorticoid ,  CPI-17 ,  RNAi ,  Pharmacology in General ,  Bio pharmaceutics
Research theme for competitive and other funds  (5):
  • 2011 - 2013 Role of miRNAs in the development of bronchial smooth muscle hyperresponsiveness in allergic asthma
  • 2008 - 2010 Mechanisms involved in the development of bronchial smooth muscle hyperresponsiveness in allergic bronchial asthma
  • 2006 - 2007 Identification of transcription factors of contractile element of bronchial smooth muscle and its change in activity at airway hyperresponsiveness
  • 2006 - 2007 Mechanisms for the induction of bronchial smooth muscle hyperresponsiveness in allergic bronchial asthma
  • Mechanisms involved in the pathogenesis of air way hyperresponsiveness in allergic asthma.
Papers (96):
  • Kai Y, Motegi M, Suzuki Y, Harada Y, Takeuchi H, Kon R, Ikarashi N, Chiba Y, Kamei J, Sakai H. Increased Rac1 activation in the enhanced carbachol-induced bronchial smooth muscle contraction of repeatedly antigen-challenged mice. Biological & pharmaceutical bulletin. 2019. 42. 9. 1605-1607
  • Ikarashi N, Mizukami N, Kon R, Kaneko M, Uchino R, Fujisawa I, Fukuda N, Sakai H, Kamei J. Study of the Mechanism Underlying the Onset of Diabetic Xeroderma Focusing on an Aquaporin-3 in a Streptozotocin-Induced Diabetic Mouse Model. International journal of molecular sciences. 2019. 20. 15
  • Kai Y, Motegi M, Suzuki Y, Takeuchi H, Harada Y, Sato F, Chiba Y, Kamei J, Sakai H. Up-regulation of Rac1 in the bronchial smooth muscle of murine experimental asthma. Basic & clinical pharmacology & toxicology. 2019. 125. 1. 8-15
  • Sakai H, Ishida T, Sato K, Mandokoro K, Yabe S, Sato F, Chiba Y, Kon R, Ikarashi N, Kamei J. Interference of Skin Scratching Attenuates Accumulation of Neutrophils in Murine Allergic Contact Dermatitis Model. Inflammation. 2019. 42. 6. 2226-2235
  • Suto W, Sakai H, Chiba Y. Sustained exposure to prostaglandin D2 augments the contraction induced by acetylcholine via a DP1 receptor-mediated activation of p38 in bronchial smooth muscle of naive mice. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2019. 55. 1-13
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MISC (146):
  • 須藤 航, 河島 史歩, 酒井 寛泰, 千葉 義彦. 長時間prostaglandin D2処置によるDP1受容体-p38活性化を介した気管支平滑筋過敏性の誘導. 日本薬学会年会要旨集. 2019. 139年会. 3. 72-72
  • 上田 千裕, 神野 奈緒子, 須藤 航, 平林 敬浩, 竹ノ谷 文子, 塩田 清二, 高崎 一朗, 酒井 寛泰, 千葉 義彦. アレルギー性喘息モデルマウスの気管支平滑筋におけるPACAP受容体Adcyaplr1発現の減少. 日本薬学会年会要旨集. 2019. 139年会. 3. 72-72
  • Wataru Suto, Hiroyasu Sakai, Yoshihiko Chiba. Sustained exposure to prostaglandin D <inf>2</inf> augments the contraction induced by acetylcholine via a DP <inf>1</inf> receptor-mediated activation of p38 in bronchial smooth muscle of naive mice. Journal of Smooth Muscle Research. 2019. 55. 1-13
  • Yuki Kai, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei, Hiroyasu Sakai. Role of Rac1 in augmented endothelin-1-induced bronchial contraction in airway hyperresponsive mice. Journal of Pharmacological Sciences. 2019. 141. 106-110
  • 田島楓, 安藤祐介, 兼平暖, 酒井寛泰, 湯本哲郎, 里史明. 乳がん細胞浸潤におけるCol8a1の役割. 日本薬学会年会要旨集(CD-ROM). 2019. 139th. 3. ROMBUNNO.22PO-pm216S-139
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Professional career (1):
  • (BLANK)
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