Sakai Hiroyasu

サカイヒロヤス | Sakai Hiroyasu

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： https://jupiter.hoshi.ac.jp/lab/seitaiyakuri/BiomolecularPharmacology/Home.html

Research field (3)： Pharmacology , Pharmaceuticals - health and biochemistry , Functional biochemistry

Research keywords (26)： anti-cancer drugs , Muscle atrophy , Cisplatin , サイトカイン , ケモカイン , smooth muscle contraction , 気管支喘息 , RhoA , 気管支平滑筋 , 下痢 , 消化管分泌 , 気道過敏性 , カルシウム感受性 , microRNA (miRNA) , glucocorticoid , CPI-17 , 転写因子 , ゲラニルゲラニル化 , アレルギー性気管支喘息 , RNAi , Ca^<2+>感受性 , 機能生物化学 , 生物系薬学 , 薬理学一般 , Bio pharmaceutics , Pharmacology in General

Research theme for competitive and other funds (13)：

2024 - 2027 スギ花粉症時の鼻粘膜過敏性形成におけるペリオスチンの病態生理学的意義の同定
2022 - 2025 miR-29-3p発現上昇を介するシスプラチン誘発筋萎縮の多角的解析
2018 - 2021 Identification and functional analysis of novel biomarker miRNA in cisplatin-induced muscle atrophy
2015 - 2018 Possible involvement of epigenomic alterations in the development of bronchial smooth muscle hyperresponsiveness in allergic asthma
2014 - 2018 次世代の”包括的緩和医療”を支える最先端基礎/臨床融合型研究の基盤形成

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Papers (146)：

Rinka Saito, Yui Shinozaki, Keito Tabata, Yui Nishinaka, Koki Yokoyama, Risako Kon, Hiroyasu Sakai, Tomoo Hosoe, Nobutomo Ikarashi. Tokishakuyakusan alleviates ultraviolet-induced skin pigmentation by decreasing the expression of melanogenesis-related enzymes. Journal of Ethnopharmacology. 2024. 332
Koki Yokoyama, Keito Tabata, Yui Shinozaki, Rinka Saito, Risako Kon, Hiroyasu Sakai, Tomoo Hosoe, Nobutomo Ikarashi. Effects of Tokishakuyakusan, Keishibukuryogan, and Kamishoyosan on the expression and activity of drug-metabolizing enzymes in the liver and small intestine. Pharmacological Research - Natural Products. 2024. 4. 100055-100055
Yoshihiko Chiba, Yamato Yamane, Tsubasa Sato, Wataru Suto, Motohiko Hanazaki, Hiroyasu Sakai. Extracellular acidification attenuates bronchial contraction via an autocrine activation of EP2 receptor: Its diminishment in murine experimental asthma. Respiratory physiology & neurobiology. 2024. 324. 104251-104251
Yu Miyauchi, Miho Kiyama, Shinki Soga, Hayato Nanri, Takayuki Ogiwara, Shiori Yonamine, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Tomoo Hosoe, et al. Downregulation of Genes for Skeletal Muscle Extracellular Matrix Components by Cisplatin. Biological & pharmaceutical bulletin. 2024. 47. 11. 1846-1850
Ken Sato, Yoshida Satoshi, Yu Miyauchi, Fumiaki Sato, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Tomoo Hosoe, Hiroyasu Sakai. Downregulation of PGC-1α during cisplatin-induced muscle atrophy in murine skeletal muscle. Biochimica et biophysica acta. Molecular basis of disease. 2024. 1870. 1. 166877-166877

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MISC (371)：

齋藤凜佳, 篠崎優衣, 西中ゆい, 田端慶斗, 横山公紀, 今理紗子, 酒井寛泰, 細江智夫, 五十嵐信智. Elucidation of the mechanism by which tokishakuyakusan inhibits melanogenesis. 日本薬学会年会要旨集(Web). 2024. 144th
横山公紀, 田端慶斗, 篠崎優衣, 西中ゆい, 齋藤凜佳, 今理紗子, 酒井寛泰, 細江智夫, 五十嵐信智. Relationship between skin pigmentation caused by ultraviolet and aging. 日本薬学会年会要旨集(Web). 2024. 144th
木山美穂, 宮内優, 里史明, 今理紗子, 五十嵐信智, 千葉義彦, 細江智夫, 酒井寛泰. Effect of cisplatin on changing in the gene expression of collagen and elastin in dermal fibroblast. 日本薬学会年会要旨集(Web). 2024. 144th
南里駿仁, 曽我眞希, 木山美穂, 荻原隆行, 宮内優, 今理紗子, 五十嵐信智, 千葉義彦, 細江智夫, 酒井寛泰. Examination of endoplasmic reticulum stress response in skeletal muscles of mice treated with various anticancer drugs. 日本薬学会年会要旨集(Web). 2024. 144th
染谷柚杏, 千種佑也, 曽我眞希, 南里駿仁, 木山美穂, 荻原隆行, 宮内優, 千葉義彦, 今理紗子, 五十嵐信智, et al. Investigation of E3 ubiquitin ligase with altered gene expression during cisplatin-induced muscle atrophy. 日本薬学会年会要旨集(Web). 2024. 144th

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Professional career (1)：

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Work history (5)：

2018/04 - 現在 Hoshi University Hoshi University, Hoshi University
2014/04 - 2018/03 Hoshi University Hoshi University
2008/09 - 2014/03 Hoshi University Hoshi University
2006/10 - 2008/09 University of Massachusetts Medical School, Department of Physiology, Postdoctoral fellow
2000/04 - 2008/03 Dept. Pharmacol., Hoshi Univ.

Committee career (2)：

日本薬理学会評議員
日本緩和医療薬学会評議員(社員)

Awards (9)：

2022 - 星薬科大学大谷記念研究助成金受賞
2020 - 日本平滑筋学会日本平滑筋学会優秀論文賞 Sustained exposure to prostaglandin D2 augments the contraction induced by acetylcholine via a DP1 receptor-mediated activation of p38 in bronchial smooth muscle of naive mice
2014 - 日本平滑筋学会日本平滑筋学会優秀論文賞 Augmented bronchial smooth muscle contractility induced by aqueous cigarette smoke extract in rats
2014 - 日本緩和医療薬学会日本緩和医療薬学会優秀発表賞 5-FU 誘発下痢発症時の CXCL1 発現亢進における NF- κ B の関与 : 5-FU 誘発下痢におけるクルクミンの効果
2013 - 日本緩和医療薬学会日本緩和医療薬学会優秀発表賞抗がん剤による神経障害ならびに下痢発現メカニズム解明における多施設共同研究 (第 4 報): 結腸における5-FU誘発下痢発症時の好中球の関与

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Association Membership(s) (5)：

気道過敏性研究会 , 日本アレルギー学会 , 日本薬学会 , 日本薬理学会 , 日本緩和医療薬学会

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