Rchr
J-GLOBAL ID:200901086343893787   Update date: Dec. 22, 2019

Arita, Makoto

Arita, Makoto
Research field  (4): Molecular biology ,  Functional biochemistry ,  Biological pharmacy ,  General medical chemistry
Research keywords  (5): Metabolomics ,  Lipoquality ,  Regulation of Inflammation ,  Bioactive molecules ,  Lipid Biochemistry
Research theme for competitive and other funds  (10):
  • 2015 - 2020 「リポクオリティ」領域研究の国際連携
  • 2015 - 2020 脂肪酸クオリティの最先端リピドミクスと生理的意義の解明
  • 2015 - 2020 「リポクオリティ」領域研究の推進
  • 2015 - 2018 脂質代謝バランス異常を伴う疾患の病態解明と創薬に向けた基盤研究
  • 2010 - 2015 ω3系脂肪酸の代謝と生理的機能についての包括的メタボローム解析
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Papers (118):
  • Shishikura K, Kuroha S, Matsueda S, Iseki H, Matsui T, Inoue A, *Arita M. Acyl-CoA synthetase 6 regulates long chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice. FASEB J. 2019. 33. 12. 14194-14203
  • Nakashima Y, *Sakai Y, Mizuno Y, Furuno K, Hirono K, Takatsuki S, Suzuki H, Onouchi Y, Kobayashi T, Tanabe K, Hamase K, Miyamoto T, Aoyagi R, Arita M, Yamamura K, Tanaka T, Nishio H, Takada H, Ohga S, *Hara T. Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease. Cardiovasc Res. 2019
  • Sawane K, Nagatake T, Hosomi K, Hirata S, Adachi J, Abe Y, Isoyama J, Suzuki H, Matsunaga A, Fukumitsu S, Aida K, Tomonaga T, Arita M, *Kunisawa J. Dietary omega-3 fatty acid ameliorates allergic rhinitis via eosinophilic production of the anti-allergic lipid mediator 15-hydroxyeicosapentaenoic acid in mice. Nutrients. 2019. 11. 2868
  • Watanabe Y, *Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, Sasahara M, Arita M, Hida S, Taniguchi S, Suda T, *Takatsu K. Bi-directional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation. FASEB J. 2019. 33. 11. 11821-11835
  • Naoe S, *Tsugawa H, Takahashi M, Ikeda K, *Arita M. Characterization of lipid profiles after dietary intake of polyunsaturated fatty acids using integrated untargeted and targeted lipidomics. Metabolites. 2019. 9. 241
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MISC (17):
  • Yamamoto T, *Miyata J, Arita M, Fukunaga K, Kawana A. Current state and future prospect of therapeutic strategy targeting cysteinyl leukotriene metabolism in asthma. Respir Invest. 2019. 57. 6. 534-543
  • Ishihara T, Yoshida M, *Arita M. Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis. Int Immunol. 2019. 31. 9. 559-567
  • Miyata J, *Fukunaga K, Kawashima Y, Ohara O, Arita M. Cysteinyl leukotriene metabolism of human eosinophils in allergic disease. Allergol Int. 2019
  • Tsugawa H, Ikeda K, Arita M. The importance of bioinformatics for connecting data-driven lipidomics and biological insights. Biochim Biophys Acta. 2017. 1862. 762-765
  • *Arita M. Eosinophil polyunsaturated fatty acid metabolism and its potential control of inflammation and allergy. Allergol Int. 2016. 65. S2-S5
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Patents (6):
  • アレルギー性疾患の予防または治療のための医薬組成物
  • Therapeutic Agent against Influenza
  • 光学活性な新規抗炎症性代謝物
  • オメガ3脂肪酸由来の新規抗炎症性代謝物
  • 新規抗炎症性化合物
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Books (8):
  • Lipidomics, Technologies and Applications (Ekroos, K. eds.)
    Willey-VCH, Weinheim 2012
  • 生体膜の分子機構(梅田真郷/編)
    化学同人 2014
  • 脂質代謝異常と関連疾患(下巻)
    Life-Science Information Center 2015
  • Bioactive Lipid Mediator (Yokomizo T, Murakami M, eds.)
    Springer 2015
  • Chronic Inflammation, Mechanisms and Regulation (Miyasaka M, Takatsu K, eds.)
    Springer 2016
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Lectures and oral presentations  (215):
  • Novel omega-3 autacoid resolving E1: receptor identification and anti-inflammatory properties
    (36th Annual Meeting of the Society for Leukocyte Biology 2003)
  • ω3 derived lipid mediator resolvin E1: stereochemistry, receptor and anti-inflammatory and protective action in colitis
    (9th International Conference of Bioactive Lipids in Cancer, Inflammation and Related Diseases 2005)
  • Novel protective lipid mediators and neutrophils: resolvins and protectins
    (International Symposium of Molecular Cell Biology of Macrophages and Dendritic cells 2006 2006)
  • 炎症を緩和する脂質メディエーター -オメガ3脂肪酸由来のResolvinとProtectin-
    (第128回東京脂質談話会 2006)
  • オメガ3脂肪酸から産生される抗炎症性脂質メディエーター
    (第16回日本脂質栄養学会 2007)
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Education (3):
  • 1988 - 1992 The University of Tokyo Faculty of Pharmaceutical Sciences
  • 1992 - 1994 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 1994 - 1997 The University of Tokyo Graduate School of Pharmaceutical Sciences
Work history (8):
  • 1997/04/01 - 2000/06/30 The University of Tokyo Assistant Professor
  • 2000/07/01 - 2003/06/30 Harvard Medical School Postdoctoral Fellow
  • 2003/07/01 - 2006/09/30 Harvard Medical School Instructor
  • 2006/10/01 - 2007/03/31 JST Researcher
  • 2007/04/01 - 2014/03/31 The University of Tokyo Associate Professor
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Awards (3):
  • 2005 - Young Investigator Award: 9th International Conference of Eicosanoids other Bioactive Lipids in Cancer, Inflammation & Related Diseases (San Francisco)
  • 2009 - Young Scientists' Prize of Ministry of Education, Culture, Sports, Science and Technology, Japan
  • 2016 - 日本脂質栄養学会ランズ賞学術賞
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