Yano Takamitsu

ヤノタカミツ | Yano Takamitsu

Affiliation and department：
Job title： CEO and Representative Director
Other affiliations (1)：

University of California, Santa Barbara

Homepage URL (2)： https://triplexbio.tech/ja/ , https://triplexbio.tech/

Research field (4)： Structural biochemistry , Chemical biology , Molecular biology , Genomics

Research keywords (15)： RNA , Programmed Ribosomal Frameshift , Nucleic acid medicine , Pyrrole-Imidazole polyamide , Translation control , mRNA quality control , Molecular design , Drug discovery science , Drug Delivery , Gene Therapy , AI-assisted research system , Molecular simulation , Duchenne Muscular Dystrophy , Mitochondrial DNA , Mitochondrial encephalomyopathy

Research theme for competitive and other funds (2)：

2021 - Animal testing of novel therapeutic molecules for Duchenne Muscular Dystrophy
2011 - Research experiment of therapeutic mitochondrial DNA-binding compounds (ML1 polyamide) for mitochondrial diseases

Papers (2)：

Takamitsu Yano, Nono Takeuchi-Tomita, Takuya Ueda, Richard H. Haas. Pyrrole-imidazole polyamide, a synthetic DNA-binding compound, is effective at increasing levels of wild-type mtDNA in both cybrid cells and MELAS patient-derived fibroblast cells with the MELAS A3243G mutation by a selective promotion of wild-type replication. MITOCHONDRION. 2013. 13. 6. 924-925
Takamitsu Yano, Masashi Tanaka, Noboru Fukuda, Takuya Ueda, Hiroki Nagase. Loss of mutant mitochondrial DNA harboring the MELAS A3243G mutation in human cybrid cells after cell-cell fusion with normal tissue-derived fibroblast cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2010. 25. 1. 153-158

Patents (2)：

SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR INDUCING -1 FRAME SHIFT AND COMPOSITION
Polyamide compound and pharmaceutical composition for treating mitochondrial genetic diseases

Lectures and oral presentations (6)：

The selective replication activation of wild-type mtDNA by a polyamide compound in cybrid cells and MELAS patient-derived fibroblast cells
(2013)
The novel therapeutic strategy for mitochondrial DNA disease: A selective promotion of wild-type mitochondrial DNA replication by a synthetic DNA-binding compound
(2011)
Successful preferential propagation of wild-type mitochondrial DNA in human cells harboring the mt tRNALeu(UUR) A3243G mutation by a synthetic DNA-binding compound
(United Mitochondrial Disease Foundation, Mitochondrial Medicine 2011: Chicago 2011)
Normal fibroblast nuclear transfer causes selective loss of mutant mitochondrial DNA harboring the A3243G mutation in human cybrid cells
(The 7th Annual Conference of the Japanese Society of Mitochondrial Research and Medicine (J-mit) 2007)
Preferential loss of mitochondrial DNA harboring the pathogenic mutation tRNALeu(UUR) 3243 A->G in human somatic cell hybrids
(The 5th Annual Conference of the Japanese Society of Mitochondrial Research and Medicine (J-mit) 2005)

ｍore...

Education (6)：

Akita Prefectural Yuzawa High School
Hirosaki University Faculty of Agriculture and Life Science
University of California, Santa Barbara College of Letters and Science, Department of Biochemistry and Molecular Biology
Yamagata University Faculty of Science Molecular Genetics, Department of Biological Science
University of Tsukuba Medical Genetics, Graduate School of Medical Sciences

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Professional career (1)：

Doctor of Philosophy (PhD) (Lifesciences) (The University of Tokyo)

Work history (6)：

2016/11 - 現在 Triplex Therapeutics Inc. CEO
2015/11 - 2016/03 University of Tsukuba School of Medicine Research Scientist
2014/02 - 2016/01 Ibaraki Prefectural University of Health Science University Hospital Research Scientist
2012/07 - 2013/06 University of California, San Diego Department of Neuroscience, School of Medicine Visiting Scholar
2012/04 - 2013/03 Keio University Center for Integrated Medical Science, School of Medicine Assistant Professor

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Awards (7)：

2020/02 - Venture Club Chiba Business Challenge Contest, Grand Prize in second place
2019/11 - Chiba City Industrial Promotion Foundation Venture Cup Chiba Business Plan Competition, Award of Excellence
2018/01 - Chiba Prefecture Business Model Competition 2017, Incentive Award
2013/06 - Burroughs Wellcome Fund 2013 Burroughs Wellcome Scholarship Award
2011/09 - Asia Society for Mitochondrial Research and Medicine Young Investigator Award (YIA)

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Association Membership(s) (5)：

AMERICAN CHEMICAL SOCIETY , THE JAPANESE SOCIETY OF MITOCHONDRIAL RESEARCH AND MEDICINE , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本ミトコンドリア学会 , 日本分子生物学会

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