Rchr

J-GLOBAL ID：200901086438462325 Update date: Mar. 11, 2024

EIJI KIKUCHI

キクチエイジ | EIJI KIKUCHI

Affiliation and department：
Job title：教授

Research field (1)： Urology

Research keywords (6)：前立腺癌 , 前立腺肥大症 , 副腎腫瘍 , 勃起不全 , 上部尿路癌 , 膀胱癌

Research theme for competitive and other funds (35)：

2022 - 2025 Trial of differential diagnosis by a highly sensitive rapid test method to detect exosomes specific for urinary tract infections.
2021 - 2024 尿中CD55/CD9共陽性エクソソームを標的とした膀胱癌の新規診断・治療法の確立
2018 - 2021 Development of novel therapeutic modality by integrated analysis of immune environment of renal cell carcinoma and remodeling after inhibition of angiogenesis
2018 - 2021 Drug repositioning approaches for novel intravesical treatment against bladder cancer
2017 - 2020 Establishment of the novel treatment strategy against urothelial carcinoma controlling for cancer stem-like property

2017 - 2019 The establishment of new therapeutic strategy for bladder cancer targeting to cancer stem cell

2015 - 2018 Elucidation of refractory mechanism to the molecular targeted therapy for renal cell carcinoma

2015 - 2018 Role of chemokine in urothelial cancer progression

2015 - 2017 The new strategy for urothelial carcinoma by inhibiting autophagy

2015 - 2017 Antitumor effect by regulation of EZH2 on urothelial carcinoma

2014 - 2017 Novel anti-cancer therapeutic strategy with mTORC1/2 inhibitor against bladder cancer

2014 - 2016 科学研究費(学術研究助成) 基盤研究C

2013 - 2015 New treatment strategy of refractory prostate cancer by regulation of androgen-androgen receptor axis and PI3K/Akt pathway

2013 - 2015 NVP-BEZ235 Therapy for Bladder Cancer and Prevention of Tumor Invasion and Metastasis

2012 - 2015 Elucidation of molecular targets based on epithelial-mesenchymal transition for the treatment of renal cell carcinoma

2014 - 2015 慶應義塾学事振興資金個人研究B

2014 - 2015 第41回大和証券ヘルス財団研究助成

2013 - 2014 慶應義塾学事振興資金個人研究B

2012 - 2013 第24回佐川がん研究助成

2012 - 2013 慶應義塾学事振興資金個人研究A

2011 - 2013 Establishment of the novel treatment strategy against urothelial carcinoma controlling for the transcription factors

2011 - 2013 科学研究費(学術研究助成) 基盤研究C

2011 - 2012 Liposomal PTEN Gene Therapy in an Orthotopic Bladder Cancer Modeland Prevention of Tumor Invasion and Metastasis

2011 - 2012 Liposomal IL-21/IL-15 Gene Therapy in an Orthotopic Bladder Cancer Model and Prevention of Tumor Invasion and Metastasis

2010 - 2012 Functional analysis of miRNAs in microenvironment of CRPC.

2010 - 2011 第31回がん集学的治療研究財団助成

2009 - 2011 Microenviroment and organ specific metastases in urological cancers as tools to elucidate molecular mechanism of carcinogenesis and tumor development.

2008 - 2010 The chemotherapeutic strategy with a novel NF-kappa B inhibitor in bladder cancer

2008 - 2010 科学研究費(学術研究助成) 基盤研究C(一般)

2007 - 2008 Functional analysis of angiotensin II in tumor angiogenesis of prostate cancer

2006 - 2007 Development of new chemotherapy for refractory prostate cancer

2006 - 2007 Establishment of new treatment strategy for diabetic erectile dysfunction

2001 - 2002 Establishment of radiotherapy combined with antisense bcl-2 oligodeoxynucleotide in prostate cancer

1999 - 2000 前立腺癌におけるトロンボスポンジンとプロテアーゼを介する浸潤機構の解明とその治療

1997 - 1998 Thrombospodinを用いた腎細胞癌の治療

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Papers (473)：

Minami Omura, Takeo Kosaka, Hiroaki Kobayashi, Keisuke Shigeta, Kazuhiro Matsumoto, Satoshi Hara, Eiji Kikuchi, Shuji Mikami, Hideyuki Saya, Yasufumi Sato, et al. Vasohibin-1 Expression Can Predict Pathological Complete Remission of Advanced Bladder Cancer with Neoadjuvant Chemotherapy. Annals of surgical oncology. 2024
菊地栄次, 安井孝周, 山本博之, 早川望, 伊藤悠城, 畠山真吾, 河嶋厚成, 森實修一. 日本泌尿器科学会NCD事業update 2023. 西日本泌尿器科学会総会抄録集. 2023. 75回. 178-178
茂田啓介, 小坂威雄, 長谷川政徳, 安水洋太, 田中伸之, 武田利和, 松本一宏, 水野隆一, 浅沼宏, 菊地栄次, et al. 化学療法体制尿路上皮癌におけるIDH2蛋白阻害薬の抗腫瘍効果の検討(IDH2 inhibitor restores cytotoxic effect of chemo agents in chemo-resistant UC by suppressing metabolic rewiring). 日本癌学会総会記事. 2023. 82回. 1055-1055
茂田啓介, 長谷川政徳, 菱木貴子, 内藤善子, 三上修治, 松本一宏, 水野隆一, 宮嶋哲, 菊地栄次, 佐谷秀行, et al. 抗癌剤耐性尿路上皮癌における代謝リプログラミング制御機構の解明と新規治療法の開発(Investigating the Underlying Mechanism of Metabolic Reprogramming in Chemo-resistant Urothelial Carcinoma). 日本癌学会総会記事. 2023. 82回. 1188-1188
Keisuke Shigeta, Masanori Hasegawa, Takako Hishiki, Yoshiko Naito, Yuto Baba, Shuji Mikami, Kazuhiro Matsumoto, Ryuichi Mizuno, Akira Miyajima, Eiji Kikuchi, et al. IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer. The EMBO journal. 2023. e110620

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MISC (1,215)：

久冨木原良平, 菊地栄次, 菊地栄次, 茂田啓介, 荻原広一郎, 有田祐起, 秋田大宇, 鈴木達也, 水野隆一, 大家基嗣, et al. 膀胱癌の筋層浸潤評価におけるVI-RADSと膀胱鏡検査の役割. 泌尿器画像診断・治療技術研究会プログラム・抄録. 2021. 8th
早川望, 菊地栄次, 鈴木重明, 大家基嗣. Pembrolizumab投与後に重症筋無力症を来たした1例. 泌尿器科紀要. 2020. 66. 6. 190-190
Ryuichi Mizuno, Kimiharu Takamatsu, Nobuyuki Tanaka, Nozomi Hayakawa, Takeo Kosaka, Eiji Kikuchi, Mototsugu Oya. Predictors of first line systemic therapy for metastatic renal cell carcinoma in IMDC favorable risk patients. JOURNAL OF CLINICAL ONCOLOGY. 2020. 38. 15
Kimiharu Takamatsu, Ryuichi Mizuno, Nozomi Hayakawa, Nobuyuki Tanaka, Takeo Kosaka, Eiji Kikuchi, Mototsugu Oya. The change of serum C-reactive protein levels during molecular-targeted treatments could predict the response to anti-PD-1 treatment in metastatic renal cell carcinoma patients. JOURNAL OF CLINICAL ONCOLOGY. 2020. 38. 15
與座直利, 中澤龍斗, 青木直人, 松村かおり, 薄場渉, 西智弘, 勝岡由一, 佐々木秀郎, 菊地栄次, 吉岡まき, et al. 後腹膜に発生した褐色脂肪腫(Hibernoma)の一例. 泌尿器外科. 2020. 33. 5. 547-548

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Books (21)：

南山堂医学大辞典
南江堂 2015
EBM 泌尿器疾患の治療 2015-2016
中外医学社 2015
2015年卒後教育テキスト (第20巻1号)
日本泌尿器科学会 2015
2014年卒後教育テキスト (第19巻2号)
日本泌尿器科学会 2014
Advances in medicine and biology volume 67
Nova Science Publishers 2013

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Lectures and oral presentations (260)：

前立腺癌細胞に対する5FU系経口抗癌剤S-1とドセタキセル併用による抗腫瘍効果およびその作用機序の検討
(第19回泌尿器科分子・細胞研究会 2010)
腎周囲脂肪組織原発混合型脂肪肉腫の一例
(第601回日本泌尿器科学会東京地方会 2010)
膀胱全摘術後9年目に残存尿道および鼡径部リンパ節へ再発した膀胱癌の1例
(第600回日本泌尿器科学会東京地方会 2009)
局所進行性前立腺癌に対する外部照射治療の成績
(第25回前立腺シンポジウム 2009)
Gemcitabineとcisplatinの化学療法に起因したreversible posterior leukoencephalopathy syndromeの一例
(第74回日本泌尿器科学会東部総会 2009)

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Education (1)：

1988 - 1994 Keio University School of Medicine

Professional career (1)：

博士(医学) (慶應義塾大学)

Work history (14)：

2019/04 - 現在 St.Marianna University School of Medicine Department of Urology
2017/11 - 2019/03 Keio University School of Medicine Department of Urology
2009/04 - 2017/10 Keio University School of Medicine Department of Urology assistant professor
2005/06 - 2009/03 Keio University School of Medicine Department of Urology staff
2004/06 - 2005/05 Fussa Hospital Department of Urology Medical director

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Awards (15)：

2020/10 - Japanese Journal of Clinical Oncology 2020 Best Reviewer Award
2019/05 - The Journal of Urology 2018 Best of Reviewer
2016/05 - The Journal of Urology 2015 Best of Reviewer
2016/04 - 第16回AKUA研究助成
2016/04 - 日本泌尿器科学会第25回研究助成

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Association Membership(s) (17)：

日本癌学会 , アジア性機能学会 , 日本癌治療学会 , 国際性機能学会 , 日本透析医学会 , 米国泌尿器科学会 , 日本内分泌学会 , 日本性機能学会 , 日本内視鏡外科学会 , 日本泌尿器科学会 , 日本泌尿器内視鏡学会 , 日本内分泌外科学会 , 欧州泌尿器科学会 , 泌尿器科再建再生研究会 , 日本腎泌尿器疾患予防医学研究会 , 泌尿器科分子・細胞研究会 , 日本泌尿器腫瘍学会

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