Rchr
J-GLOBAL ID：200901086471955574
Update date: Sep. 04, 2024
Sasakawa Chihiro
ササカワ チヒロ | Sasakawa Chihiro
Affiliation and department：
Job title：
director
Homepage URL (1)：
http://www.ims.u-tokyo.ac.jp/bac/h.p./mainpage.html
Research field (3)：
Immunology
, Bacteriology
, Molecular biology
Research keywords (8)：
immunology
, infection biology
, Cellular Microbiology
, Bacterial Infectious Disease
, Bacterial Pathogenesis
, 細胞微生物学
, 細菌感染症
, 病原細菌学
Research theme for competitive and other funds (47)：
- 2012 - 2017 Generalization of harmonized supramolecular motility machinery and its diversity
- 2011 - 2015 Study of bacterial stratagem to circumvent host innate immune system and its application.
- 2008 - 2011 Study of Shigella infectious strategy for the intestinal barrier
- 2006 - 2011 Matrix of Infection Phenomena
- 2006 - 2010 Support for Research Techniques and Materials
- 2006 - 2010 Studies of proliferation and pathogenesis of extracellular gram-negative bacterial pathogens
- 2008 - 2009 赤痢菌感染におけるmicroRNAの役割の解明
- 2008 - 2008 赤痢菌の腸粘膜バリアー感染戦略の解明
- 2002 - 2007 細菌の粘膜感染機構と宿主応答の行方
- 2002 - 2007 Study on bacterial infectious strategy and the host responses
- 2005 - 2005 感染現象の研究マトリックスを構築するための企画調査研究
- 2002 - 2005 Investigation of molecular interplay between Shigella effectors and the host factors
- 2003 - 2004 The studies of Helicobacter pylori on the functions of effector protein and the mechanisms of gastric mucosa infection.
- 2001 - 2002 赤痢菌の粘膜上皮感染を決定するエフェクター蛋白質と微小管の相互作用の解明
- 1999 - 2000 Induction of Cell Death upon Infection with Shigella flexneri
- 1998 - 1998 細菌感染症発症機構の分子生物学的手法による解析とその治療への応用
- 1997 - 1998 Molecular mechanisms for shigellae invasion of and spreading among colonic epithelial cells.
- 1996 - 1998 Studies on molecular genetics of bacterial pathogenesis
- 1997 - 1997 病原細菌由来ビルレンス因子と宿主細胞の相互連関との解析
- 1995 - 1997 迅速核酸分析法を用いた実験動物腸内に生息する腸内細菌の分類とモニタリング法の確立
- 1996 - 1996 化膿連鎖球菌のF蛋白とヒト組織型フィブロネクチンにおける相互作用の解析
- 1996 - 1996 豚丹毒菌のヘモリジン遺伝子に関する遺伝学的および生物学的研究
- 1996 - 1996 細菌由来病原因子による標的細胞機能変換作用の解析
- 1995 - 1996 Molecular mechanism of invasion of epithelial cells by Shigella
- 1994 - 1995 Molecular genetical study of low-temperature growth in Listeria monocytogenes
- 1994 - 1994 赤痢菌ビルレンス発現調節の分子機構
- 1992 - 1994 Analysis of molecular mechanisms of invasion of epithelial cells by Shigella
- 1991 - 1993 Developement of live attenuated anti-Shigella vaccine based on molecular pathogenesis studies
- 1990 - 1993 Molecular Genetics of Micrbial Pathogenesis
- 1989 - 1992 The significance of Chromosomal Virulence Genes of Shigella flexneri in the Pathogenesis of Bacillary Dysentery
- 1988 - 1990 The Roles of the Virulence Factors of Shigella Flexneri in Cell to Cell Spread.
- 1987 - 1989 Molecular Genetic Studies on Bacterial Pathogenicity
- 1986 - 1988 Structure and Function of the plasmid genes associated with epethelial invasion in Shigella Flexneri
- 1987 - 1987 腸管系病原性大腸菌染色体DNAの分子遺伝学的特性の解析
- 1985 - 1986 New Tn5 variants with various drug resistance markers and suicide vector for transposon mutagenesis
- ヘリコバクターピロリーの感染動態とその制御法
- 赤痢菌の無毒化ワクチンの開発
- ヒト特異的病原細菌の動物感染モデルの開発
- 細菌感染症の予防あるいは制御法の開発
- 細菌感染とシグナル伝達
- 赤痢菌病原性の分子生物学的研究
- Study on H.pylori infection and development of the control
- Development of Safer attenuated ┣DBShigella(/)-┫DB vaccine
- Development of animal model for human-specific pathogenic bacteria
- Development of drugs or vaccines for prevention and control of bacterial infections diseases.
- Bacterial Infection and Signal Transduction
- Molecular study on the Pathogenicity of Shigella
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Papers (111)：
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Hiroshi Ashida, Chihiro Sasakawa, Toshihiko Suzuki. A unique bacterial tactic to circumvent the cell death crosstalk induced by blockade of caspase-8. EMBO Journal. 2020. 39. 17
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Ryota Otsubo, Hitomi Mimuro, Hiroshi Ashida, Jun Hamazaki, Shigeo Murata, Chihiro Sasakawa. Shigella effector IpaH4.5 targets 19S regulatory particle subunit RPN13 in the 26S proteasome to dampen cytotoxic T lymphocyte activation. Cellular Microbiology. 2019. 21. 3. e12974
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Shiho Suzuki, Toshihiko Suzuki, Chihiro Sasakawa. IAP family members are involved in inflammasome activation in response to bacterial infection. Japanese Journal of Bacteriology. 2018. 73. 1. 130-130
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Suzuki S, Suzuki T, Mimuro H, Mizushima T, Sasakawa C. Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation. EMBO reports. 2018. 19. 1. 89-101
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Ryu Jinhyeob, 大坪 亮太, 飯田 真珠子, 芦田 浩, 笹川 千尋, 三室 仁美. 宿主ユビキチンE3リガーゼによる腸管病原性大腸菌の病原性抑制作用(Host E3 ubiquitin ligase limits pathogenicity of Enteropathogenic E. coli). 日本細菌学雑誌. 2017. 72. 1. 60-60
ｍore...
MISC (67)：
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Hiroshi Ashida, Toshihiko Suzuki, Chihiro Sasakawa. Shigella infection and host cell death: a double-edged sword for the host and pathogen survival. Current Opinion in Microbiology. 2021. 59. 1-7
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鈴木 志穂, 鈴木 敏彦, 三室 仁美, 笹川 千尋. GLMNは細菌感染におけるinflammasome活性化のnegative regulatorである. 日本細菌学雑誌. 2016. 71. 1. 94-94
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Hiroshi Ashida, Chihiro Sasakawa. Shigella IpaH family effectors as a versatile model for studying pathogenic bacteria. Frontiers in Cellular and Infection Microbiology. 2016. 5
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鈴木 志穂, 三室 仁美, 小川 道永, 芦田 浩, 鈴木 仁人, 真田 貴人, 笹川 千尋. 赤痢菌IpaH7.8 E3ユビキチンリガーゼはglomulinを標的化して炎症を活性化する(Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin to activate inflammasomes). 日本細菌学雑誌. 2015. 70. 1. 217-217
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Hiroshi Ashida, Minsoo Kim, Chihiro Sasakawa. Manipulation of the host cell death pathway by Shigella. CELLULAR MICROBIOLOGY. 2014. 16. 12. 1757-1766
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Books (2)：
-
医科細菌学(編集)改訂第3版
南江堂 2001
-
赤痢菌の宿主細胞侵入・拡散とその発現調節(分担執筆)
菜根出版,医学微生物学の新しい展開 1993
Education (3)：
- 1974 - 1978 The University of Tokyo Graduate School of Medicine
- 1972 - 1974 Chiba University Graduate School of Pharmaceutical Sciences
- 1968 - 1972 Chiba University Faculty of Science
Professional career (2)：
- (BLANK) (The University of Tokyo)
- (BLANK) (Chiba University)
Work history (9)：
- 2013/04 - 現在 Chiba University Research Center for Pathogenic Fungi and Microbial Toxicoses diector
- 1998 - 2001 Osaka University Research Institute for Microbial Diseases Adjunct Professor
- 1986 - 1995 The University of Tokyo
- 1986 - 1995 University of Tokyo, Assistant Professor
- 1995 - - 東京大学 教授
- 1995 - - University of Tokyo, Professor
- 1978 - 1986 The University of Tokyo
- 1978 - 1986 University of Tokyo, Research Assistant
- 1980 - 1983 Washington University at St. Louis Medical School Postdoctral Fellow
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Committee career (4)：
- 2016 - 2023 American Society for Microbiology American Academy of Microbiology
- 2011 - 2017 Science Council of Japan Member
- 2012 - 2015 Federation of Microbiological Society of Japan Chaiman
- 2006 - 2008 Japanese Society for Bacteriology Director
Awards (7)：
Association Membership(s) (5)：
日本免疫学会
, 米国微生物学会
, 日本分子生物学会
, 日本細菌学会
, 日本獣医学会
