Takada Shinji

タカダシンジ | Takada Shinji

Affiliation and department：
Job title： Professor
Other affiliations (1)：

National Institute for Basic Biology Developmental Biology

Homepage URL (1)： http://www.nibb.ac.jp/cib2/

Research field (2)： Developmental biology , Molecular biology

Research keywords (4)：細胞間情報伝達 , 体節 , 発生 , 形態形成

Research theme for competitive and other funds (33)：

2023 - 2028 領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営
2021 - 2024 Wntリガンドの動態計測に基づく組織発生機構の解析
2019 - 2021 体節形成における分節時計と空間情報の相互作用の解析
2018 - 2021 Regulation of spatial distribution of Wnt in developing neural tube
2017 - 2020 Tissue Pattern Formation Generated by Local Signal

2017 - 2019 シグナルによる発生時計の制御のしくみとその意義

2017 - 2019 Analysis of cellular dynamics and function of Wnt-responding cells which constitute the thymic microenvironment in mice

2015 - 2019 Molecular basis of periodic cellular dynamics to facilitate convergence movements

2013 - 2018 Investigating the mechanisms for GSC regulation in mouse gametogenesis

2013 - 2018 Role of heparan sulfate nanostructures in morphogen distribution and signal reception

2012 - 2017 Analysis and Synthesis of Multidimensional Immune Organ Network

2012 - 2017 Moleculara mechanism and regulation of the lymphoid organ

2011 - 2014 Molecular basis underling distribution of secreted signaling proteins

2011 - 2013 An approach for finding of novel biological clock focusing on the segmentation of the pharyngeal arch

2011 - 2012 分泌性シグナルタンパク質の細胞内輸送機構とその破綻による疾患の発症機序の研究

2006 - 2010 Molecular mechanism underlying metameric morphogenesis

2005 - 2009 Movement and function of secreted signaling proteins in the extracellular environment

2004 - 2005 補償作用と核内倍加現象に焦点をおいた葉形態形成の分子機構の解明

2003 - 2005 Molecular mechanism generating variable roles of signaling molecule during development

2000 - 2004 体節中胚葉の増殖と初期分化

1998 - 2001 Functional analysis of Wnt genes expressed in the dorsal neural tibe of the mouse embryo

2000 - 2000 マウス初期発生におけるWntシグナルの受容機構の解析

2000 - 2000 中枢神経系の背腹軸形成を制御するシグナル分子の研究

2000 - 2000 細胞間シグナル分子による細胞分化とがん化の制御

1999 - 1999 マウス初期発生におけるWntシグナルの受容機構の解析

1999 - 1999 脊椎動物の分節性の分枝基盤とその進化

1998 - 1998 マウス初期発生におけるWntシグナルの受容機構の解析

1997 - 1997 脊椎動物の初期発生と肢芽形成におけるWnt遺伝子の機能の解析

1993 - 1997 発生・形態形成の個体レベルにおける分子生物学的研究

1995 - 1995 マウス頭尾軸形成におけるWnt-3a遺伝子の役割

1990 - 1990 癌遺伝子導入トランスジェニックマウスを用いた血液幹細胞株の樹立

脊椎動物初期発生の分子遺伝学的解析

Molecular Genetics of Uertebrate early Development

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Papers (128)：

Hideko Utsumi, Taijiro Yabe, Sumito Koshida, Akira Yamashita, Shinji Takada. Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos. Frontiers in Cell and Developmental Biology. 2024. 12
Thi Hong Nguyen Tran, Ritsuko Takada, Elena Krayukhina, Takahiro Maruno, Yusuke Mii, Susumu Uchiyama, Shinji Takada. Soluble Frizzled-related proteins promote exosome-mediated Wnt re-secretion. Communications Biology. 2024. 7. 1
Minako Suzuki, Shinji Takada, Yusuke Mii. Dissection of N-deacetylase and N-sulfotransferase activities of NDST1 and their effects on Wnt8 distribution and signaling in Xenopus embryos. Development, Growth & Differentiation. 2024
Takuma Shinozuka, Motoko Aoki, Yudai Hatakeyama, Noriaki Sasai, Hiroshi Okamoto, Shinji Takada. Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 2023
Taijiro Yabe, Koichiro Uriu, Shinji Takada. Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. Nature communications. 2023. 14. 1. 2115-2115

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MISC (13)：

Takuma Shinozuka, Shinji Takada. Morphological and functional changes of roof plate cells in spinal cord development. Journal of Developmental Biology. 2021. 9. 3
Shinji Takada, Sayumi Fujimori, Takuma Shinozuka, Ritsuko Takada, Yusuke Mii. Differences in the secretion and transport of Wnt proteins. JOURNAL OF BIOCHEMISTRY. 2017. 161. 1. 1-7
Hisato Kondoh, Shinji Takada, Tatsuya Takemoto. Axial level-dependent molecular and cellular mechanisms underlying the genesis of the embryonic neural plate. DEVELOPMENT GROWTH & DIFFERENTIATION. 2016. 58. 5. 427-436
Taijiro Yabe, Shinji Takada. Molecular mechanism for cyclic generation of somites: Lessons from mice and zebrafish. DEVELOPMENT GROWTH & DIFFERENTIATION. 2016. 58. 1. 31-42
Atsuo Kawahara, Taijiro Yabe, Satoshi Ansai, Shinji Takada, Masato Kinoshita. Genome editing in Zebrafish and Medaka. Targeted Genome Editing Using Site-Specific Nucleases: ZFNs, TALENs, and the CRISPR/Cas9 System. 2015. 119-131

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Books (4)：

Genome editing in zebrafish and medaka in Targeted Genome Editing Using Site-Specific Nuclease
Springer 2015
Roles of Wnt signalling in the developing dorsal neural tube. In Neural Development (eds. Uyemura, K., Kawamura, K. & Yazaki, T.) Keio Symposia for Life Science and Medicine
Springer-Verlag Tokyo 1999
S1マッピング: 平井久丸編「図説ブロッティング」
講談社サイエンティフィック 1987
Regulation of mouse casein gene expression by glucocorticoid. In Hormonal Regulation of Gene Expression (edited by Institute of Endocrinology, Gunma University). Gunma Symposia on Endocrinology
Center for Academic Publications, Japan, Tokyo, VNU Science Press BV, Utrecht 1987

Professional career (1)：

Doctor of Pharmaceutical Science (The University of Tokyo, Graduate School of Pharmaceutical Sciences)

Committee career (2)：

2014 - 2019 日本発生生物学会運営委員
2009 - 2012 日本発生生物学会運営委員

Association Membership(s) (2)：

日本発生生物学会 , 日本分子生物学会

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