Research field (1)：
Pharmaceuticals - analytical and physicochemistry
Research keywords (2)：
NMR 溶液構造解析 Tauタンパク質
, NMR
Research theme for competitive and other funds (11)：
2010 - 2012 Discovery of novel anti-cancer drug :The search for regulatory elements of eukaryotic initiation factor 4E.
2011 - 2011 タウ重合に必須なCH-π相互作用阻害剤の開発:認知症治療薬開発の基盤研究
2009 - 2011 Studies of structure-function relationship and self-aggregation mechanism of tau protein for development of the therapeutic drug of Alzheimer's disease.
2008 - 2010 Development of the inhibitor for tangle formation of tau protein : Basic research for prevention of Altzheimer disease
2005 - 2007 Elucidation of Self-aggregation Mechanism of Tau Protein : Basic Research for Drug Development of Inhibiting Alzheimer's disease
2001 - 2003 Elucidatiop of Tangle Formation Mechanism Based on 3D-structural Analysis of Tau Protein
認知症発症機構の解明と治療・予防薬の開発
tauタンパク質の溶液構造解析
有機化合物のNMR研究
Conformational Analysis of Microtubule Binding Domain in Tau
Study on NMR spectra of organic compounds
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Papers (68)：
Tomohiro Tsuchida, Kouki Susa, Tomohiro Kibiki, Takahiro Tsuchiya, Katsushiro Miyamoto, Yasuko In, Katsuhiko Minoura, Taizo Taniguchi, Toshimasa Ishida, Koji Tomoo. Structural study of the recognition mechanism of tau antibody Tau2r3 with the key sequence (VQIINK) in tau aggregation. Biochemical and biophysical research communications. 2021. 585. 36-41
Akiko Asano, Maki Nakagawa, Chihiro Miyajima, Mami Yasui, Katsuhiko Minoura, Takeshi Yamada, Mitsunobu Doi. Effect of the powerful plasticity of the tert-butyl side chain on the conformational equilibrium of ascidiacyclamides. Journal of Peptide Science. 2021. 27. 12
Tomohiro Tsuchida, Kouki Susa, Tomohiro Kibiki, Takahiro Tsuchiya, Katsushiro Miyamoto, Yasuko In, Katsuhiko Minoura, Taizo Taniguchi, Toshimasa Ishida, Koji Tomoo. Crystal structure of the human tau PHF core domain VQIINK complexed with the Fab domain of monoclonal antibody Tau2r3. FEBS Letters. 2020. 594. 13. 2140-2149
