Sumi-Ichinose Chiho

イチノセ(スミ) チホ | Sumi-Ichinose Chiho

Affiliation and department：
Job title： Associate Professor

Research field (1)： Pharmacology

Research keywords (5)： Parkinson's Disease , Dystonia , Nitric oxide , Catecholamine , Tetrahydrobiopterin

Research theme for competitive and other funds (11)：

2022 - 2025 テトラヒドロビオプテリンによる神経・循環器系の機能調節と疾患治療への挑戦
2016 - 2019 Tetrahydrobiopterin-deficiency causes hypertension with fluctuation, bradycardia and priapism.
2013 - 2016 Study on the disease induced by imbalance of tetrahydrobiopterin-metabolism and research on the mechanisms for protection against the state.
2010 - 2012 Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular disease
2004 - 2005 Developmental disturbance in model mice with abnormal pterin metabolism

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Papers (50)：

Yui Suganuma, Chiho Sumi-Ichinose, Taiki Kano, Kazuhisa Ikemoto, Taei Matsui, Hiroshi Ichinose, Kazunao Kondo. Quinonoid dihydropteridine reductase, a tetrahydrobiopterin-recycling enzyme, contributes to 5-hydroxytryptamine-associated platelet aggregation in mice. Journal of Pharmacological Sciences. 2022. 150. 173-179
Katsuya Miyajima, Yusuke Sudo, Sho Sanechika, Yoshitaka Hara, Mieko Horiguchi, Feng Xu, Minori Suzuki, Satoshi Hara, Koichi Tanda, Ken-ichi Inoue, et al. Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin. Journal of Neurochemistry. 2022. 161. 2. 129-145
Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Kazuhisa Ikemoto, Noriko Ihira, Hiroshi Ichinose, Kazunao Kondo. Priapism caused by partial deficiency of tetrahydrobiopterin through hypofunction of the sympathetic neurons in sepiapterin reductase gene-disrupted mice. Journal of Inherited Metabolic Disease. 2022. 45. 3. 621-634
Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Toshiharu Nagatsu, Kazunao Kondo. Salivary neopterin and related pterins: their comparison to those in plasma and changes in individuals. J Biochem . 2021. 170. 4. 559-567
Katsuya Miyajima, Chiaki Kawamoto, Satoshi Hara, Masayo Mori-Kojima, Tamae Ohye, Chiho Sumi-Ichinose, Nae Saito, Toshikuni Sasaoka, Daniel Metzger, Hiroshi Ichinose. Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways. J Biol Chem . 2021. 296. 100544-100544

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MISC (27)：

川畑伊知郎, 来延新, 大宅史織, 森田淳一, 加藤茂樹, 田渕明子, 福地守, 津田正明, 大橋一正, 水野健作, et al. In vitroとin vivoにおける、Rho/MAL/SRF経路を介したV-1遺伝子による黒質線条体のドーパミン系の機能の調節(In vitro and in vivo regulation of the nigrostriatal dopaminergic function by V-1 gene via the Rho/MAL/SRF pathway). パーキンソン病・運動障害疾患コングレスプログラム・抄録集. 2015. 9回. 66-66
Y. Suganuma, T. Kano, K. Ikemoto, C. Ichinose, T. Nomura, K. Kondo. Orally administered tetrahydrobiopterin (BH4) suppresses platelet aggregation via intraplatelet production of nitric oxide. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2015. 13. 908-909
Yui Suganuma, Taiki Kano, Kazuhisa Ikemoto, Chiho Ichinose, Takahide Nomura, Kazunao Kondo. Antiplatelet effect of tetrahydrobiopterin in mouse whole blood aggregation and its NO-independent mechanism. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 132P-132P
Yui Suganuma, Kazuhisa Ikemoto, Chiho Ichinose, Takahide Nomura, Kazunao Kondo. Anti-platelet effect of tetrahydrobiopterin on mouse whole blood. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 85P-85P
Ichinose H, Homma D, Sumi-Ichinose C, Nomura T, Kondo K. GTP Cyclohydrolase Regulation: Implications for Brain Development and Function. Advances in Pharmacology. 2013. 68. 23-35

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Books (8)：

GTP Cyclohydrolase Regulation: Implications for Brain Development and Function.
Academic Press 2013
Dopa-responsive dystonia. ,
Elsevier Science (USA) 2003
Effects of acute and repeated Administration of Tetrahydrobiopterin to 6-Pyruvoyltetrahydropterin Synthase Knockout Mice.
SPS Verlagsgesellschaft (Germany), 2003, 2003
Tetrahydrobiopterin differentially regulates the biosynthesis of catecholamines and serotonin, Implication in neuropsychiatric disorders.
Kluwer Academic/Plenum Publishers 2002
The gene for human aromatic L-amino avid decarboxylase, the enzyme for serotonin and catecholamine biosynthesis.
Elsevier Science B. V. 1995

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Lectures and oral presentations (85)：

Effect of adrenalin alpha-2 agonists on thrombogenesis: risk in animal anesthesia with medetomidine, but safety in clinical sedation with dexmedetomidine.
(EPHAR2024 (The Federation of 9th European Pharmacological Societies), Athens, Greece)
低酸素が炎症性サイトカイン刺激下のヒト血管内皮細胞内のテトラヒドロビオプテリン(BH4)量に及ぼす効果
(第36回日本プテリジン研究会 2024)
セピアプテリン還元酵素遺伝子ノックアウトマウスで観察されるチロシン水酸化酵素Ser40のリン酸化亢進
(第36回日本プテリジン研究会 2024)
Platelet aggregation enhancement by sedatives, not by clinical dexmedetomidine but by medetomidine for animal anesthesia.
(19th World Congress of Basic & Clinical Pharmacology 2023, Glasgow, Unatied Kingdom)
Serotonin plays an essential role in platelet aggregation via BH4-requiring biosynthesis regulated by Quinonoid dihydropteridine reductase.
(The 87th Annual Scientific Meeting of The Japanese Circulation Society, JCS2023 FUKUOKA)

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Education (2)：

1988 - 1992 Nagoya University Graduate School of Medicine
1982 - 1988 Nagoya University School of Medicine

Professional career (1)：

MD, Ph. D (Nagoya University)

Work history (4)：

2003/04 - 現在 Fujita Health University Department of Pharmacology, School of Medicine Associate Professor
1999/04 - 2003/03 Fujita Health University Department of Pharmacology, School of Medicine Assistant Professor
1992/04 - 1999/03 Fujita Health Universirty Department of Pharmacology, School of Medicine Research Associate
1994/12 - 1996/08 Institut de Genetique et de Biologie Moleculaire et Cellulair

Committee career (1)：

1999/04 - 現在日本薬理学会評議員

Awards (1)：

1999 - 愛知県医師会難病研究者表彰パーキンソン病の発生機序とその代償機構を探る;ドパミン神経系の分子生物学的研究

Association Membership(s) (5)：

THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS , THE JAPAN NEUROSCIENCE SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE PHARMACOLOGICAL SOCIETY

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