Koyasu Shigeo

2006 - 2011 Role of dendritic cells in bridging innate and adaptive immune responses during bacterial infection.

2010 - 2010 Role of natural helper cell in anti-helminth immunity.

2006 - 2008 Mechanism for antigen capture during Helicobacter infection.

2006 - 2008 Role of PI3-kinase in anti-helminth immunity involving IgE and gastrointestinal mast cells.

2002 - 2008 Development of new therapies for infectious diseases through understanding of the symbiosis strategy of pathogenic microbes.

2005 - 2006 Role of gut-associated lymphoid tissues in Helicobacter infection.

2005 - 2006 Role of PI3K/NF-κB pathway in B cell functions.

2004 - 2006 Role of PI3-kinase in the development and function of mast cells.

2002 - 2006 The regulation of innate immune responses by dendritic cells through the interaction with microbes.

2002 - 2005 Artificial regulation of immune system through the PI3K signaling.

2002 - 2004 Role of PI3-kinase in the development of mast cells and anti-helminth immunity.

2001 - 2003 Mechanisms of B cell tolerance against peripheral antigen.

2000 - 2003 Development of new animal models for autoimmune neuronal diseases.

2001 - 2002 Role of interaction of dendritic cells and pathogenic microbes in innate immunity.

2000 - 2002 Novel targets of cyclosporin A and FK506.

1999 - 2002 T cell receptor signal transduction involved in T cell anergy.

1997 - 2002 Functional analysis of cellular immunity in infectious diseases.

2000 - 2001 Regulation of Th1 and Th2 responses by interferon-γ produced by dendritic cells.

1999 - 2001 Cellular mechanisms of tolerance breakdown in autoantibody production.

1999 - 2000 Studies on the rejection of transplanted bone marrow cells by NK and NKT cells.

1998 - 1999 Regulation of the T cell receptor expression by molecular chaperons.

1998 - 1999 Studies on the rejection of transplanted bone marrow cells by NK and NKT cells

1998 - 1999 ITAM: a signal transduction motif mediating T cell receptor signals.

1998 - 1999 Function of the T cell-specific MAPK cascade.

1997 - 1999 Signal transduction of the T cell receptor in T cell anergy.

1997 - 1998 Studies on the rejection of transplanted bone marrow cells by NK and NKT cells.

1997 - 1998 Function of MAPK superfamily in the T cell receptor-mediated signal transduction.

1997 - 1998 Regulation of the T cell receptor expression by molecular chaperons.

1996 - 1998 Functional analysis of peripheral tolerance.

1996 - 1997 Differentiation mechanisms of T cells and NK cells.

1996 - 1997 Factors determining the sensitivity of T cell receptor signals.

1996 - 1997 Studies on the rejection of transplanted bone marrow cells by NK and NKT cells.

1993 - 1996 Functional analysis of FcεRIγ in T cell receptors in LGL.

1993 - 1996 Functional analysis of FcεRIγ in T cell receptors on LGL.

1989 - 1991 Human T cell recognition of HIV envelope glycoproteins.

1987 - 1988 Elucidation of switch mechanisms between resting and growth phases using cloned T cells.

1986 - 1987 Regulatory mechanisms of cell growth mediated by growth factors and their receptors.

1986 - 1987 Role of intracellular calcium ion on the production of IL-2 and expression of the IL-2 receptor.

1985 - 1986 Regulatory mechanisms of cell growth mediated by growth factors and their receptors.

1984 - 1985 Structure and function of immune cell growth factors.

1983 - 1984 Structure and function of immune cell growth factors.