Rchr

J-GLOBAL ID：200901087159856506 Update date: Apr. 19, 2024

Tomiyama Yoshiaki

トミヤマヨシアキ | Tomiyama Yoshiaki

Affiliation and department：
Other affiliations (1)：

Osaka University Faculty of Medicine, Medical School, Dept of Hematology and Oncology Associate Professor,Associate Professor

Homepage URL (1)： http://www.med.osaka-u.ac.jp/pub/bldon/www/home.html

Research field (3)： Hematology and oncology , Cell biology , Molecular biology

Research keywords (6)： ITP , GPIIb-IIIa , 血小板 , ITP , GPIIb-IIIa , Platelet

Research theme for competitive and other funds (59)：

2019 - 2022 Molecular mechanism of platelet integrin activation and association with vascular lesion
2018 - 2021 Analysis of regulatory mechanism for platelet integrin activation kinetics
2018 - 2021 Characteriziation of regulatory molecules of platelet integrin function and their clinical application
2016 - 2019 Analysis of platelet integrin signaling and association with vascular diseases
2015 - 2018 Elucidation of the role of kindlin in the functional expression of beta3 integrins and investigation of the kindlin-related new molecules

2015 - 2018 Identification and characterization of integrin inside-out signaling molecules employing a newly developed expeimental system

2014 - 2017 Analysis of regulatory mechanism of sustained integrin alphaIIbbeta3 activation.

2013 - 2016 Arterial thrombosis and platelet integrin activation.

2014 - 2015 インテグリンを制御する細胞骨格蛋白ネットワークの解明と造血器腫瘍治療への応用

2012 - 2015 Analysis of regulatory molecule in platelets for thrombosis employing CMK cell system

2011 - 2015 Elucidation of the role of ILK in the functional expression of beta3 integrins and investigation of the ILK-related molecules

2011 - 2013 Development of new therapy based on a molecular mechanism of integrin activation signaling via integrin activation complex

2009 - 2011 Analysis of positive or negative regulatory mechanism for thrombus formation

2008 - 2010 Cloning and analysis of molecules involved in functional regulation of β3 integrin

2008 - 2010 Development of new therapy based on a molecular mechanism of integrin activation signaling via integrin binding proteins

2008 - 2010 Analysis of inhibitory mechanism and antithrombotic effects of a novel anti-platelet function molecule, semaphorin 3A

2007 - 2008 Analysis of regulatory mechanism for α_<IIb>β_3 function by employing newly developed experimental system.

2006 - 2007 Analysis of anti-platelet and anti-thrombotic effects of a neuron guidance molecule,semaphorin 3A

2006 - 2007 Identification of signaling molecules associated with β3 integrins using random mutagenesis

2006 - 2007 Development of new targeted therapy ford thrombosis or cancer based on a molecudar mechanism of iniegrin activation signaling.

2006 - 2007 アディポネクチンの作用機序解明:新しい受容体の同定と結合蛋白の網羅的解析

2005 - 2006 Establishment of a novel IFN therapy with little side effects

2004 - 2004 新規インターフェロンLimitinを中心としたがん治療戦略の確立

2003 - 2004 Difference of biological activities and signals between IFN-ζ/limitin and IFN-α

2003 - 2004 Characterization of regulatory proteins for β3 integrins.

2002 - 2003 Analyses of inhibitory effects induced by the loss-of-function mutant integrin cellular functions

2002 - 2002 新種のインターフェロンlimitin:新しい癌治療薬としての流動的検討

2001 - 2002 Biological activity of limitin and adiponectin

2001 - 2002 CD36 AS A GENETIC BACKGROUND FOR METABOLIC SYNDROME AND ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

2001 - 2002 Clinical application of limitin that has anti-tumor and anti-viral activity

2001 - 2001 骨髄抑制の少ない新規インターフェロン様蛋白limitinの癌治療への応用

2001 - 2001 新規造血制御分子limitin,adiponectinの生体内役割の解析

2000 - 2001 Development of Oxidized LDL Receptor (CD36) Knockout Mice and Its Application to Elucidation of Molecular Mechanism for Atherogenesis

2000 - 2001 Structural and functional analyzes of integrin αvβ3 : identification of ligand-binding sites in the αv subunit of αvβ3 and development of inhibitor for αvβ3

2000 - 2001 Regulatory mechanism of β3 integrin function via signaling molecules

2000 - 2000 機能変異インテグリン導入によるがん細胞遊走能および転移能の解析

1999 - 2000 Establishment of A New Strategy for the Treatment of Atherosclerosis by Inhibition of an Oxidized LDL Receptor, CD36

1999 - 1999 新規に固定した造血制御分子の作用機序およびその生体内意義

1999 - 1999 ストローマ細胞由来造血制御分子の同定とその生体内意義

1998 - 1999 Pathophysiological Analysis of CD36 Deficiency As a Novel Cause of Idiopathic Cardiomyopathy; Role of Long-chain Fatty Acid Transporter, CD36, in Myocardial Energy Metabolism

1998 - 1999 Mechanisms of autoantibody-mediated pathological thrombosis in the mouse model with antiphospholipid symdrome

1998 - 1998 造血幹細胞支持に関わるストローマ細胞由来分子の同定-造血幹細胞への結合能を指標とした新しいクローニング法を用いて-

1997 - 1998 Signaling through integrin alpha IIb beta3

1997 - 1998 Gene targeting of CD36, the major receptor for oxidized low density lipoproteins

1996 - 1996 トロンボポエチン産生調節機構の解析

1996 - 1996 リコンビナント蛋白を用いた血小板インテグリンαIIbβ3の機能発現機構の解析

1996 - 1996 酸化LDL受容体阻害による新しい粥状動脈硬化治療法の開発

1995 - 1995 酸化LDL受容体CD36の構造と機能に関する研究-CD36欠損細胞および分子生物学的手技を用いた検討-

1995 - 1995 血小板インテグリンαIIbβ_3の活性化機構に関する研究

1994 - 1994 血小板インテグリンαIIbβ_3の構造と機能に関する分子生物学的解析

1994 - 1994 Oxidized LDL受容体としてのCD36(GPIV)に関する分子生物学的研究

1993 - 1993 ヒト白血病細胞における増殖シグナル伝達分子の活性化とその制御機構に関する研究

血栓・止血の分子機構、血小板異常症の分子病態

特発性血小板減少性紫斑病における血小板抗体

血小板無力症の遺伝子解析

血小板インテグリンαIIbβ3の構造機能連関

Study on anti-platelet autoantibodies in chronic ITP

Molecular genetic basis of Glanzmann's thrombasthenia

Structure-function relationship in integrin αIIbβ3

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Papers (159)：

Tomoko Kiyokawa, Kazuya Mimura, Keisuke Nagamine, Kotarosumitomo Nakayama, Mikiko Horiuchi, Tamayo Morikawa, Mika Hosokawa, Mayumi Nakao, Masayuki Endo, Tadashi Kimura, et al. FNAIT pathogenesis determined by serial analysis of three subsequent pregnancies of a woman with severe fetal and neonatal alloimmune thrombocytopenia (FNAIT) with anti-HPA-4b and anti-HPA-5b alloantibodies in the first sibling. International journal of hematology. 2023. 118. 1. 146-150
細川美香, 永峰啓丞, 青地寛, 中山小太郎純友, 櫻木美基子, 森川珠世, 中尾まゆみ, 清川知子, 加藤恒, 冨山佳昭, et al. 多発性骨髄腫患者に対する抗CD38モノクローナル抗体製剤投与が直接抗グロブリン試験に与える影響. 日本輸血細胞治療学会誌. 2022. 68. 3. 412-421
芥田敬吾, 福島健太郎, 中田継一, 林悟, 堤一仁, 日野彬央, 戸田淳, 草壁信輔, 上田智朗, 藤田二郎, et al. 同種造血幹細胞移植後ITPの診断における網状血小板比率、抗血小板自己抗体測定の意義. 日本血栓止血学会誌. 2022. 33. 2. 288-288
芥田敬吾, 福島健太郎, 中田継一, 林悟, 堤一仁, 日野彬央, 戸田淳, 草壁信輔, 上田智朗, 藤田二郎, et al. 同種造血幹細胞移植後ITPの診断における網状血小板比率、抗血小板自己抗体測定の意義. 日本血栓止血学会誌. 2022. 33. 2. 288-288
Masayuki Kubo, Kazuya Sakai, Masaki Hayakawa, Hirokazu Kashiwagi, Hideo Yagi, Yoshinobu Seki, Atsushi Hasegawa, Haruyuki Tanaka, Itsuto Amano, Yoshiaki Tomiyama, et al. Increased cleavage of von Willebrand factor by ADAMTS13 may contribute strongly to acquired von Willebrand syndrome development in patients with essential thrombocythemia. Journal of thrombosis and haemostasis : JTH. 2022. 20. 7. 1589-1598

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MISC (138)：

KASHIWAGI Hirokazu. Reference guide for management of adult idiopathic thrombocytopenic purpura (ITP): 2019 version. Rinsho Ketsueki. 2019. 60. 8. 877-896
櫻木美基子, 味村和哉, 中山小太郎純友, 細川美香, 中尾まゆみ, 森川珠世, 清川知子, 青地寛, 永峰啓丞, 遠藤誠之, et al. 高力価抗Rh17(抗Hro)を有するD--型の母親からの出生に成功した、胎児・新生児溶血性疾患(HDFN)の一例当院での対応と工夫. 日本輸血細胞治療学会誌. 2019. 65. 2. 368-368
Keigo Akuta, Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shinji Kunishima, Fumiaki Banno, Koichi Kokame, Nobuko Nishiura, Hisashi Kato, Shigenori Honda, Yuzuru Kanakura, et al. alpha IIb(R990W), a Gain-of Function Mutation of alpha IIb beta 3, Knock-in Mice Show Moderately Impaired Thrombopoiesis. BLOOD. 2018. 132
Hisashi Kato, Nobuko Nishiura, Keigo Akuta, Hirokazu Kashiwagi, Koichi Kokame, Toshiyuki Miyata, Yuzuru Kanakura, Yoshiaki Tomiyama. Platelet Integrin alpha IIb beta 3 Activation Kinetics in Inherited Platelet Functional Disorders similar to the Role of ADP Receptor P2Y12, Caldag-GEFI and Kindlin-3 alpha IIb beta 3 Activation By inside-out Signaling. BLOOD. 2018. 132
Yoji Ishida, Yoshiaki Tomiyama. Autoimmune thrombocytopenia. Autoimmune Thrombocytopenia. 2017. 1-229

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Books (2)：

Platelet membrane proteins as adhesion receptors
Platelets om Thrombotic and Non-thrombotic Disorders, Combridge University Press 2002
Platelet membrane proteins as adhesion receptors
Platelets om Thrombotic and Non-thrombotic Disorders, Combridge University Press 2002

Education (2)：

- 1981 Osaka University Faculty of Medicine
- 1981 Osaka University Faculty of Medicine

Professional career (2)：

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Committee career (3)：

1995 - 日本血液学会評議員
1994 - 日本血栓止血学会評議員
1993 - 日本輸血学会評議員

Awards (3)：

2018/06 - 日本血栓止血学会岡本賞 Shosuke award
1998 - 内科学会奨励賞
1995 - 日本血液学会学会奨励賞

Association Membership(s) (7)：

国際血栓止血学会 , 日本臨床血液学会 , 日本輸血学会 , 日本血栓止血学会 , 日本内科学会 , 日本血液学会 , アメリカ血液学会

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