Institute of Science Tokyo Graduate School of Medical and Dental Sciences Medical and Dental Sciences Oral Health Sciences Bacterial Pathogenesis
About Institute of Science Tokyo Graduate School of Medical and Dental Sciences Medical and Dental Sciences Oral Health Sciences Bacterial Pathogenesis
2014 - 2018 Effects of periodontitis induced inflammasome activation on arteriosclerosis and its control
2014 - 2017 Elucidation of caspase-1 activation inhivition mechanism by Vibrio parahaemolyticus effector VopQ
2015 - 2017 インフラマゾーム活性化機構の新機軸
2012 - 2015 Mechanism of Leptospira interrogans host cell invasion
2012 - 2014 Visualizing of caspase-1 activation upon bacterial infection
2011 - 2014 The bacterial effector-mediated inhibition of caspase-1 activation
2010 - 2012 Analysis of new NLRP3 activation passway by Vibrio cholerae
2009 - 2011 Strategy used to infect macrophages by the zoonotic bacteria Leptospira
2009 - 2010 病原性ビブリオ属細菌による宿主炎症誘導機構
2006 - 2007 Molecular mechanisms of cell death and inflammatory responses of antigen presenting cells upon infection of mucosal pathogenic bacteria
2004 - 2005 The establishment of molecular basis of Shigella-induced cell death.
2002 - 2003 ヘリコバクター・ピロリの粘膜感染機構における分子基盤の確立
2000 - 2001 Study of actin-based cell-to-cell spreading of Shigella in infected epithelial cells
1998 - 1999 赤痢菌のアクチン重合に基づく上皮細胞間感染機構の解析
環境→ヒト伝播に必要なMycobacterium ulcerans病原因子の解明
低酸素環境が拓く細菌感染-宿主応答機構の新機軸
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Papers (113):
Abass Adiza, Okano Tokuju, Boonyaleka Kotchakorn, Kinoshita-Daitoku Ryo, Yamaoka Shoji, Ashida Hiroshi, Suzuki Toshihiko. Effect of low oxygen concentration on activation of inflammation by Helicobacter pylori. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021. 560. 179-185
Kinoshita-Daitoku R, Kiga K, Miyakoshi M, Otsubo R, Ogura Y, Sanada T, Bo Z, Phuoc TV, Okano T, Iida T, et al. A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment. Nature communications. 2021. 12. 1. 2085
Okano Tokuju, Suzuki Toshihiko. Inflammasome activation inducer produced by Aggregatibacter actinomycetemcomitans causes arthritis(和訳中). 口腔病学会雑誌. 2021. 88. 1. 70-71
鈴木 敏彦. バランス(口腔免疫). 口腔病学会雑誌. 2021. 88. 1. 72-72
Prah Isaac, Ayibieke Alafate, Nguyen Thi Thu Huong, Iguchi Atsushi, Mahazu Samiratu, Sato Wakana, Hayashi Takaya, Yamaoka Shoji, Suzuki Toshihiko, Iwanaga Shiroh, et al. Virulence Profiles of Diarrheagenic Escherichia coli Isolated from the Western Region of Ghana(和訳中). Japanese Journal of Infectious Diseases. 2021. 74. 2. 115-121
Okano Tokuju, Ashida Hiroshi, Suzuki Shiho, Suzuki Toshihiko. The induction of host inflammatory responses by Porphyromonas gingiivalis. The Journal of the Stomatological Society, Japan. 2019. 86. 2. 47-47
The effect of hypoxia on Helicobacter pylori induced inflammasome activation
(第76回日本細菌学会総会 2021)
TRIF-HIF-1α signaling under hypoxia drives enhancement of inflammasome activation by P. gingivalis
(第76回日本細菌学会総会 2021)
Aggregatibacter actinomycetemcomitans induces activation of noncanonical inflammasome via lysosomal degradation
(The 48th annual meeting of the Japanese Society for Immunology 2019)
Hypoxia induces enhancement of inflammasome activation by P. gingivalis
(7th International Cytokine and Interferon Society 2019)
GLMN-cIAP1/2 axis controls inflammasome activation in response to bacterial infection
(The 92th Annual Meeting of Japanese Society for Bacteriology 2019)