Rchr
J-GLOBAL ID：200901088534570760
Update date: Sep. 05, 2024
Ichinohe Norihisa
イチノヘ ノリヒサ | Ichinohe Norihisa
Affiliation and department：
Job title：
Lecturer
Research field (2)：
Experimental pathology
, General surgery, pediatric surgery
Research keywords (35)：
細胞移植
, 小型肝細胞
, 分化
, 肝幹・前駆細胞
, 肝幹細胞
, 生体組織工学
, 骨髄間葉系幹細胞
, 移植・再生医療
, 細胞・組織
, 共培養
, 肝発生
, 胆管上皮細胞
, CD44
, 類肝組織
, 肝前駆細胞
, 肝組織形成
, 増殖
, 肝再生
, スキャフォールド
, 3次元培養
, ヒト肝幹細胞
, 毛細胆管
, 成熟化
, シリコーンゴム
, 人工肝臓
, マイクロ流体
, 基底膜
, 胆管形成
, オーバル細胞
, 再生医学
, 組織工学
, 口腔外科
, Regenerative Medicine
, Tissue Engineering
, Oral Surgery
Research theme for competitive and other funds (15)：
- 2023 - 2026 Development of designer cells for severe liver diseases treatment and analysis of their regeneration mechanism by focusing on tisse stem cells.
- 2018 - 2021 Renewal of severely damaged livers by activating hepatic progenitor cells
- 2017 - 2020 Translational research for clinical apply using liver stem cells from cell banking
- 2017 - 2020 Analysis of immunoregulation and mechanism of liver regeneration in cell transplantation
- 2017 - 2019 In vitro reconstruction of hepatic tissue
- 2014 - 2017 Translational research of the regenerative treatment of using human hepatic stem cells which were frozen by super-freezing program
- 2014 - 2016 Research for the establishment of human hepatocytic progenitor cells
- 2014 - 2016 Hepatic stem cells transplantation activates the growth of intrinsic hepatic progenitor cells in recipient rat livers.
- 2012 - 2015 Establishment of cell transplantation therapy for hepatic failure by hepatic stem/progenitor cells and/or hepatic organoids
- 2012 - 2014 Development of the liver lobule-type culture device
- 2012 - 2013 Tissue stem cells transplantation activates the growth of hepatic progenitor cells in recipient rat livers.
- 2010 - 2011 Analysis in activation of hepatic stem/progenitor cells and development of application to hepatic tissue engineering
- 2009 - 2011 Basic research for the production of human hepatocytes and the transplantation of hepatic tissues
- 2007 - 2008 Hepatic organoid formation by coculture with small hepatocytes and bone marrow stromal cells
- 2005 - 2007 Research for the formation of hepatic organoids by using human hepatic progenitor cells and the model of artificial liver device incorporated with human hepatic organoids
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Papers (30)：
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Norihisa Ichinohe, Naoki Tanimizu, Keisuke Ishigami, Yusuke Yoshioka, Naoki Fujitani, Takahiro Ochiya, Motoko Takahashi, Toshihiro Mitaka. CINC-2 and miR-199a-5p in exosomes secreted by transplanted Thy1+ cells activate hepatocytic progenitor cell growth in rat liver regeneration. Stem Cell Research and Therapy. 2023
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Naoki Tanimizu, Norihisa Ichinohe, Yasushi Sasaki, Tohru Itoh, Ryo Sudo, Tomoko Yamaguchi, Takeshi Katsuda, Takafumi Ninomiya, Takashi Tokino, Takahiro Ochiya, et al. Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo. Nature communications. 2021. 12. 1. 3390-3390
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Norihisa Ichinohe, Masayuki Ishii, Naoki Tanimizu, Toru Mizuguchi, Yusuke Yoshioka, Takahiro Ochiya, Hiromu Suzuki, Toshihiro Mitaka. Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers. Stem cell research & therapy. 2021. 12. 1. 312-312
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Naoki Tanimizu, Norihisa Ichinohe, Hiromu Suzuki, Toshihiro Mitaka. Prolonged oxidative stress and delayed tissue repair exacerbate acetaminophen-induced liver injury in aged mice. Aging. 2020. 12. 19. 18907-18927
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Tanimizu N, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, Tokino T, Ochiya T, Miyajima A, et al. Generation of functional liver tissue by establishing hepatobiliary connections ex vivo. 2020
ｍore...
MISC (10)：
Education (2)：
- 2003 - 2007 Sapporo Medical University Graduate School of Medicine
- - 2002 Hokkaido University School of Dental Medicine
Professional career (1)：
- Ph.D. (Sapporo Medical University Graduate School of Medicine)
Work history (3)：
- 2023/11 - 現在 Research Institute for Regenerative Medicine, Sapporo Medical University School of Medicine Department of Tissue Development and Regeneration Lecturer
- 2019/07 - 2023/09 Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine Department of Tissue Development and Regeneration instructor
- 2014 - 2019/06 Sapporo Medical University School of Medicine
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