Rchr
J-GLOBAL ID：200901088683266569
Update date: Nov. 03, 2024
Nakanishi Hiroshi
ナカニシ ヒロシ | Nakanishi Hiroshi
Affiliation and department：
Job title：
Professor
Research field (2)：
Oral medicine
, Neuroscience - general
Research keywords (7)：
microglia
, neuroinflammation
, Alzheimer's disease
, Porphyromonas gingivitis
, gingipain
, cathepsin B
, cathepsin E
Research theme for competitive and other funds (47)：
- 2021 - 2024 Regulatory mechanisms of the gliosis through TLR3/IFN-b signaling mediated by microglia
- 2018 - 2021 Possible involvement of impaired intrinsic microglial clock in Periodontotis-associated exacerbation of Alzheimer's disease
- 2017 - 2020 Comprehensive understanding of orofacial pain induced by dry mouth
- 2016 - 2019 Japan-China Joint Epidemiological Survey of Tibetan Elderly on Correlation between Oral Health and Cognitive Functions
- 2016 - 2018 ミクログリアのナイトライフの解析から捉える概日リズム障害発症メカニズム
- 2015 - 2018 the unravelling of the role of cathepsin in gingival overgrowth
- 2015 - 2018 Study on a microglial phenotypic switch with a focus on proteolytic response
- 2015 - 2017 Analysis of Porphyromonas gingivalis-induced neuroinflammation by multi-photon imaging of microglia dynamics
- 2012 - 2015 Involvement of glia-neuron functional interaction in intractable trigeminal neuropathic pain
- 2012 - 2015 Mechanism of the rupture of meningeal-glia limitans during chronic Periodontitis
- 2012 - 2015 Critical roles of the chromogranin A-cathepsin B system in a transition of acute pain to a chronic pain state
- 1995 - 2015 ミクログリアの生理学的ならびに病理学的機能に関する研究
- 1991 - 2015 神経細胞死における細胞内プロテアーゼの役割
- 2012 - 2014 Involvement of endosomal Toll-like receptors in the development of neuropathic pain
- 2008 - 2010 Roles of cathepsin B in the production of IL-1β as a leptomenigal toxic factor during systemic inflammation
- 2008 - 2010 Inhibition of bone destruction by phosphatidylserine-containing liposomes based on t he regulation of phagocytes functions
- 1981 - 2010 グルタミン酸受容体を介した神経伝達機構の生理と病態
- 2003 - 2009 ミクログリアによるグルタミン酸を介した神経伝達の動的制御
- 2007 - 2008 Age-dependent differential responses of glial cells and Leptomeningeas during systemic inflammation
- 2006 - 2007 Association of leptomeningeal and glial cells in the persistent pain
- 2005 - 2007 Research on the mechanism underlying the accelerated senescence in cathepsin D-deficient mice
- 2005 - 2006 顔面神経-ミクログリアの細胞膜間に想定される軸索再生分子の探索
- 2003 - 2004 The study on microglial activation by beta amyloid, peptides of Alzheimer's disease.
- 2000 - 2004 神経系におけるオートファジー・リソソームシステム
- 2002 - 2003 In situ expression of RANKL, RANK, osteoprotegerin and cytokines in osteoclasts of rat periodontal tissue
- 2002 - 2003 Regulation of glutamatergic signalings by niacrophage/microglia
- 1999 - 2000 Involvement of cathepsin E in exogenous antigen processing in primary cultured microglia
- 1997 - 2000 DESIGN AND DEVELOPMENT OF THERAPEUTIC AGENTS OF ADULT PERIODONTITIS THAT INHIBIT ARG-GINGIPAIN PRODUCED BY PORPHYROMONAS GINGIVALIS
- 1999 - 1999 エンドソーム・リソソーム系蛋白分解機構におけるカテプシンEの役割
- 1998 - 1998 エンドソーム・リソソーム系蛋白分解機構におけるカテプシンEの役割
- 1997 - 1998 歯周病原菌における蛋白分解システムとその異常の分子レベル解析
- 1997 - 1998 EXPRESSION AND FUNCTION OF CATHEPSIN E IN ACTIVATED MICROGLIA FOLLOWING FACIAL NERVE INJURY
- 1997 - 1998 Effect of overexpression of cathepsin E and Bcl-2 on neuronal death
- 1996 - 1998 ROLES OF PATHOGENIC PROTEINASES IN PERIODONTAL DISEASE
- 1997 - 1997 カテプシンEの生合成と細胞内輸送および局在化機構の解析
- 1996 - 1996 顔面神経切断に伴って増殖する反応性ミクログリアにおけるカテプシンEの性状解析
- 1996 - 1996 細胞内アスパラギン酸プロテアーゼの機能構造形成と細胞機能制御
- 1994 - 1996 DEVELOPMENT OF A NEW CLINICAL PARAMETER FOR ASSESSMENT OF PROGRESSIVE PERIODONTAL DIDEASE AND ITS THERAPEUTIC AND PREVENTIVE DRUGS
- 1995 - 1995 DNA断片化ならびに細胞内プロテアーゼの動態を指標として逆行性神経変性の検討
- 1994 - 1995 Structures and Functions of Periodontopathogenic Proteinases
- 1994 - 1994 アスパラギン酸プロテアーゼによる生理活性ペプチドの分解を介した三叉神経機能の調節
- 1994 - 1994 細胞内アスパラギン酸プロテアーゼの選別と輸送機構
- 1992 - 1993 PHYSIOLOGICAL AND PATHOLOGICAL STUDIES OF PROTEINASES IN THE RAT TRIGEMINAL GANGLION CELLS
- 1990 - 1992 THE DEVELOPMENT OF A NEW CLINICAL PARAMETER FOR DIAGNOSIS OF PERIODONTAL DISEASES AND THE NEW DRUG DESIGN
- 1991 - 1991 三叉神経節グルタミン酸性ニューロンの電気的性質ならびに投射領域に関する研究
- 1990 - 1990 歯痛の伝達機構における三叉神経節ニューロン細胞体の役割とその特性に関する研究
- 1989 - 1989 スパイク・トリガー法による黒質-線条体ドーパミン入力の解析
Show all
Papers (102)：
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Saori Nonaka, Rin Okamoto, Yui Katsuta, Shiori Kanetsuki, Hiroshi Nakanishi. Gingipain-carrying outer membrane vesicles from Porphyromonas gingivalis cause barrier dysfunction of Caco-2 cells by releasing gingipain into the cytosol. Biochemical and biophysical research communications. 2024. 707. 149783-149783
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Erika Inoue, Shiyo Minatozaki, Sachi Shimizu, Sayaka Miyamoto, Misato Jo, Junjun Ni, Hidetoshi Tozaki-Saitoh, Kosuke Oda, Saori Nonaka, Hiroshi Nakanishi. Human β-Defensin 3 Inhibition of P. gingivalis LPS-Induced IL-1β Production by BV-2 Microglia through Suppression of Cathepsins B and L. Cells. 2024. 13. 3. 283-283
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Veronika Stoka, Olga Vasiljeva, Hiroshi Nakanishi, Vito Turk. The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer. International Journal of Molecular Sciences. 2023. 24. 21. 15613-15613
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Wei Kong, Zhen Xie, Xiaokang Shang, Yoshinori Hayashi, Fei Lan, Narengaowa, Shuxuan Zhao, Hui Li, Zhenzhen Quan, Zhou Wu, et al. Zinc finger protein 335 mediates lipopolysaccharide-induced neurodegeneration and memory loss as a transcriptional factor in microglia. Glia. 2023. 71. 12. 2720-2734
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Akihiro Matsumoto, Takeo Kitazawa, Yuta Hatori, Hiroshi Nakanishi, Chie Watanabe, Tomoya Takashima, Masahiro Murakami. Targeting cellular gaps using Janus nanoparticles containing cationic polymers and surfactant lipids. Drug Discoveries & Therapeutics. 2023. 17. 2. 104-113
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MISC (45)：
Books (10)：
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Age-dependent differential activation profiles of glial cells by the leptomeninges during systemic inflammation. In Neuroimmunology Research Focus (Broglio P. V., ed)
Nova Science Publishers, Inc., New York, pp. 101-118. 2007
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Microglial Proteases. In: Neural Protein Metabolism and Function. Handbook of Neurochemistry and Molecular Neurobiology, Vol.7 (Lajtha A., ed )
Kluwer Publishing Corporation, New York, pp. 552-564. 2007
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Proteases and synaptic activity. In: Proteases in Biology and Disease. Vol.3 (Lendeckel, U. and Hooper, N., eds)
Kluwer Academic/Plenum Publishers, New York, pp.291-310 2004
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Involvement of neuronal and microglial proteinases in neuronal death
Recent Research Development in Neurochemistry 1999
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Cathepsin E in the central nervous system(jointly worked)
Aspartic Proteinases, Plenum Press 1998
ｍore...
Works (1)：
-
Analysis of NMDA-response Potentiating Factor Released from by Microglia
2001 -
Education (4)：
- - 1981 Kyushu University
- - 1981 Kyushu University Graduate School, Division of Pharmaceutical Sciences
- - 1979 Kyushu University School of Pharmaceutical Sciences
- - 1979 Kyushu University Faculty of Pharmaceutical Science
Professional career (2)：
- Ph.D. (Kyushu University)
- M. Pharm. Sci. (Kyushu University)
Work history (4)：
- 2018/04 - 現在 Yasuda Women's University Faculty of Pharmacy
- 2000/11 - 2018/03 九州大学歯学研究院 教授
- 1999/04 - 2000/10 Kyushu University School of Dentistry
- 1982/06 - 1999/03 Kyushu University School of Dentistry
Association Membership(s) (8)：
グリア研究会
, 老化促進モデルマウス(SAM)研究協議会
, 日本脳循環代謝学会
, 基礎歯科学会
, 日本生理学会
, 米国神経科学会
, 日本生化学会
, 日本薬理学会
