2018 - 2021 Characterization and purification of oligonucleotides-polymer conjugates with higher-order structure
2018 - 2020 Development of sequential and reaction process with monolithic column module for small antibodies PEGylation
2016 - 2018 Surface modification of monolithic pore for solid phaseprotein PEGylation based on its mass transfer
2014 - 2016 Development of separation process for PEGylated positional isoforms based on the intrinsic interaction with specific structure on the solid-liquid interface
2003 - 2004 刺激応答性分子集合体を利用した生体機能模倣材料の調製とその応用
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Papers (63):
Azusa Takahashi, Chisaki Fujii, Yuya Takahashi, Tatsuki Kunisawa, Yuto Nagayasu, Noriko Yoshimoto, Makoto Yoshimoto. Liposome-Papain Conjugates for Catalytic Digestion of Antibody Producing Fab Fragments. ACS applied bio materials. 2024. 7. 8. 5566-5578
野崎晋也, 吉本則子, 吉本則子, 山本修一, 山本修一. A Method for Determining the Optimum Temperature for a Polyphenol Separation Process by Reversed Phase Chromatography. 日本食品工学会誌. 2024. 25. 1
稲葉英憲, 稲葉英憲, 杉山智基, 吉本則子, 吉本則子, 山本修一, 山本修一. Continuous Monitoring of High Protein Concentrations by Optical Rotation-A Case Study for Continuous Monitoring of Monoclonal Antibody Concentrations During Ultrafiltration. 日本食品工学会誌. 2023. 24. 4
Noriko Yoshimoto. Continuous Protein Modification and Separation Process with Chromatography. Japan Journal of Food Engineering. 2022. 23. 1. 1-12
Hidenori Inaba, Kosuke Wakabayashi, Ikuo Tsujimoto, Noriko Yoshimoto, Shuichi Yamamoto. Measurement of High Protein Concentrations by Optical Rotation: A Case Study for Monitoring of Monoclonal Antibody Drug Downstream Processes. Current Protein and Peptide Science. 2021. 22. 12. 898-904
田中利来人, 吉本則子. Sequential modification reactions and separation of antibody proteins using cation exchange chromatography. 日本膜学会年会講演要旨集(CD-ROM). 2023. 45th
森田俊哉, 吉本則子. Effect of ligand species on hydrophobic chromatographic separation of antibody-drug conjugates. 日本膜学会年会講演要旨集(CD-ROM). 2023. 45th
田中みの梨, 星田尚司, 吉本則子. Retention characteristics and cell transfection efficiency of fluorescently labeled DNA in ion-exchange chromatography. 日本膜学会年会講演要旨集(CD-ROM). 2023. 45th