Research field (2)：
Pharmaceuticals - health and biochemistry
, Neuroscience - general
Research keywords (4)：
発達障害
, アルツハイマー病
, 神経変性疾患
, 精神疾患
Research theme for competitive and other funds (26)：
2022 - 2026 甲状腺機能低下を誘導する化学物質の発達神経毒性評価の精緻化に関する総合研究
2021 - 2024 咀嚼機能発達低下動物モデルの口腔機能と脳発達特性の解明
2021 - 2024 Clarification of the molecular pathogenesis of autism spectrum disorders through the analysis regarding sex differences
2021 - 2024 機能亢進型GNAS変異マウスを用いた線維性骨異形成症の病態解明と創薬展開
2021 - 2024 糖尿病における小胞体ストレス応答とSUMO化
2016 - 2019 Drug discovery research targeting the novel regulation of prefrontal dopaminergic system by the functional interaction between the sigma1 and serotonin1A receptors
2016 - 2018 Neurochemical study for cognitive behavioral therapy in mouse models of neuropsychiatric and neurodevelopmental disorders
2013 - 2016 Drug discovery research targeting brain neurochemical signals responsible for induction of abnormal behaviors in mouse models of psychiatric disorders
2011 - 2014 Study on pathophysiological roles of brain NO-NCX signal
2009 - 2010 創薬を目指した環境要因誘発精神疾患動物でのエピジェネティクス研究
2007 - 2009 ANALYSES OF DYNAMIC CHANGES AND THE FUNCTION OF TISSUE PLASMINOGEN ACTIVATOR IN ANIMAL MODELS OF DOPAMINE-RELATED MENTAL DISORDERS
2006 - 2007 Molecular mechanisms of mitochondrial dysfunction and neurotoxicity induced by Aβ-ARAD interaction
2003 - 2005 グリア細胞アポトーシス発現におけるミトコンドリア蛋白の機能的役割
2004 - 更年期の精神障害の分子機序に関する研究
2004 - 児童青年期の精神疾患の分子機序に関する研究
2004 - 神経変性疾患におけるミトコンドリアの機能的役割に関する研究
2004 - Study on the molecular mechanisms of Mood disorders in menopausal women
2004 - Study on the molecular mechanisms of child and adolescent psychiatric disorders
2004 - Study on the mitochondrial functional roles in neurodegenerative diseases
2001 - 2002 グリア細胞アポトーシスの発現機序とGキナーゼを介する制御機構の解析
2000 - 2001 Pharmaceutical activity of ubiquinone analogs
2001 - アルツハイマー病の発症分子機序ならびに情動行動障害に関する研究
2001 - Study on the molecular pathogenesis in Alzheimer’s disease
1999 - 2000 グリア細胞アポトーシスにおけるプロテアーゼの役割に関する研究
1996 - 脳グリア細胞の遅発性アポトーシスの発現機構に関する研究
1996 - Study on the molecular mechanism of delayed apoptosis of astrocytes
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Papers (151)：
Misaki Iwahashi, Takeshi Yoshimura, Wakana Harigai, Kazuhiro Takuma, Hitoshi Hashimoto, Taiichi Katayama, Atsuko Hayata-Takano. Pituitary Adenylate Cyclase-Activating Polypeptide deficient mice show length abnormalities of the axon initial segment. Journal of Pharmacological Sciences. 2023
Eiji Imado, Samnang Sun, Abrar Rizal Abawa, Takeru Tahara, Takahiro Kochi, Tran Ngoc Bao Huynh, Satoshi Asano, Shigeru Hasebe, Yoki Nakamura, Kazue Hisaoka-Nakashima, et al. Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation. Neurochemistry International. 2022. 160. 105415-105415
Yusuke Shintani, Yui Yamano, Manato Kuta, Rei Takeshita, Kazuhiro Takuma, Takuya Okada, Naoki Toyooka, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara, et al. Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice. Biochemical and biophysical research communications. 2022. 631. 146-151
Tomoya Takemoto, Masayuki Baba, Kazumasa Yokoyama, Kohei Kitagawa, Kazuki Nagayasu, Yukio Ago, Kaoru Seiriki, Atsuko Hayata-Takano, Atsushi Kasai, Daisuke Mori, et al. Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome. Molecular Brain. 2022. 15. 1. 26-26
Kana Yamamoto, Toshihiko Kuriu, Kensuke Matsumura, Kazuki Nagayasu, Yoshinori Tsurusaki, Noriko Miyake, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Mikiya Fujiwara, et al. Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia. Translational psychiatry. 2021. 11. 1. 548-548
- 1991 Osaka University School of Pharmaceutical Sciences
Professional career (1)：
博士(薬学) (大阪大学)
Work history (8)：
2015/04 - 現在 大阪大学大学院 連合小児発達学研究科 教授 (兼任)
2014/07 - 現在 大阪大学大学院 薬学研究科 教授 (兼任)
2014/07 - 現在 大阪大学大学院 歯学研究科 教授
2008/04 - 2014/07 Osaka University Graduate School of Pharmaceutical Sciences
2007/04 - 2008/03 Kanazawa University Graduate School of Natural Science and Technology
2004/04 - 2007/03 Kanazawa University Graduate School of Natural Science and Technology
1996/04 - 2004/03 Kobe Gakuin University The Faculty of Pharmaceutical Sciences
2001/10 - 2002/09 米国コロンビア大学 医学部 博士研究員
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Committee career (1)：
2001 - The Japanese Pharmacological Society Councilor
Awards (3)：
2006 - Young Scientist Award of The Japanese Pharmacological Society
2006 - The Award for Young Investigator of Japanese Society for Neurochemistry
2001 - The Pharmaceutical Society of Japan Kinki Division Encouragement Award
Association Membership(s) (15)：
国際神経化学会
, 米国神経科学学会
, 日本神経精神薬理学会
, 日本神経科学学会
, 日本神経化学会
, 日本薬学会
, 日本薬理学会
, International Society for Neurochemistry
, Society for Neuroscience
, Japanese Society of Neuropsychopharmacology
, Japan Neuroscience Society
, The Japanese Society for Neurochemistry
, The Pharmaceutical Society of Japan
, The Japanese Pharmacological Society
, Japanese Association for Oral Biology
