Rchr
J-GLOBAL ID：200901089206660952   Update date: Sep. 04, 2024

Kubo Tai

クボ タイ | Kubo Tai
Affiliation and department：
GlyTech Inc.

About GlyTech Inc.


Job title： Science Fellow
Homepage URL  (1)： http://www.aist.go.jp/RESEARCHERDB/cgi-bin/worker_detail.cgi?call=namae&rw_id=T76634771
Research field  (5)： Pharmacology ,  Applied biochemistry ,  Functional biochemistry ,  Structural biochemistry ,  Neuroanatomy and physiology
Research keywords  (9)： in vitro evolution ,  neurotransmitter receptor ,  bioactive peptide ,  peptide ,  ion channel ,  nerve transmitter substance receptor ,  acetylcholine ,  peptide ,  physiologically active substance
Research theme for competitive and other funds  (15)：
  • 2018 - 2022 Allosteric modulators that recognize the transition-states of receptor channels
  • 2016 - 2019 Discovery research of medium molecule drugs for cancer immunotherapy using in vitro molecular evolution technology
  • 2014 - 2019 3D Active Site Science in Biology
  • 2014 - 2017 Utilization of microenvironment of nanotubes in in-vitro evolution
  • 2013 - 2016 Peptide drug discovery to identify the calcium channel subfamily by molecular evolutional technique
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Papers (104)：
  • Yue Yang, Tatsuya Arai, Daisuke Sasaki, Masahiro Kuramochi, Hidetoshi Inagaki, Sumiko Ohashi, Hiroshi Sekiguchi, Kazuhiro Mio, Tai Kubo, Yuji C. Sasaki. Real-time tilting and twisting motions of ligand-bound states of α7 nicotinic acetylcholine receptor. European Biophysics Journal. 2024. 53. 1-2. 15-25
  • Kazuhiro Mio, Shoko Fujimura, Masaki Ishihara, Masahiro Kuramochi, Hiroshi Sekiguchi, Tai Kubo, Yuji C. Sasaki. Living-Cell Diffracted X-ray Tracking Analysis Confirmed Internal Salt Bridge Is Critical for Ligand-Induced Twisting Motion of Serotonin Receptors. International Journal of Molecular Sciences. 2021. 22. 10. 5285-5285
  • Shoko Fujimura, Kazuhiro Mio, Masahiro Kuramochi, Hiroshi Sekiguchi, Keigo Ikezaki, Muneyo Mio, Kowit Hengphasatporn, Yasuteru Shigeta, Tai Kubo, Yuji C. Sasaki. Agonist and Antagonist-Diverted Twisting Motions of a Single TRPV1 Channel. The Journal of Physical Chemistry B. 2020. 124. 51. 11617-11624
  • Kazuhiro Mio, Masaki Ishihara, Shoko Fujimura, Daisuke Sasaki, Shunsuke Nozawa, Kohei Ichiyanagi, Ryo Fukaya, Shin-ichi Adachi, Masahiro Kuramochi, Hiroshi Sekiguchi, et al. X-ray-based living-cell motion analysis of individual serotonin receptors. Biochemical and Biophysical Research Communications. 2020. 529. 2. 306-313
  • K. Mio, S. Fujimura, M. Kuramochi, M. Ishihara, M. Honda, M. Mio, T. Kubo, H. Sekiguchi, Y. C. Sasaki. Toward understanding of internal motion measurement with quantum probe and cryo-EM. 2019. 44. 2. 210-215
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MISC (69)：
  • 藤村章子, 三尾和弘, 倉持昌弘, 関口博史, 三尾宗代, 久保泰, 佐々木裕次, 佐々木裕次, 佐々木裕次. X線1分子追跡法によるTRPV1チャネルの3次元運動. バイオイメージング. 2018. 27. 2
  • K. Mio, K. Ikezaki, H. Sekiguchi, T. Baba, Y. Matsushita, T. Kubo, Y. C. Sasaki. Asymmetric rotational brownian motion on TRPV1 cation channel with X-ray single molecule technique. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S267-S267
  • T. Kubo, T. Baba, S. Ohashi, H. Inagaki, K. Ikezaki, K. Mio, H. Sekiguchi, Y. C. Sasaki. PAMs modulate molecular dynamics of nAChR alpha 7: direct observation by DXT and electrophysiology. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S165-S165
  • 関口博史, 徳江真紀, 西野有里, 一柳光平, 久保泰, 宮澤淳夫, 八木直人, 佐々木裕次, 佐々木裕次. 高速1分子内ダイナミクス計測で捉えるアセチルコリン受容体・機能運動. 日本蛋白質科学会年会プログラム・要旨集. 2014. 14th
  • 関口博史, 徳江真紀, 西野有里, 一柳光平, 久保泰, 宮澤淳夫, 八木直人, 佐々木裕次, 佐々木裕次. 高速1分子内ダイナミクス計測で捉えるアセチルコリン受容体・機能運動. 日本蛋白質科学会年会プログラム・要旨集. 2014. 14th
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Patents (24)：
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Books (2)：
  • 『きちんとわかるナノバイオ』、第2章「生体分子モーターで駆動するナノアクチュエータ」、第8章「バイオセンサー」
    白日社 2008
  • 『生体物理刺激と生体反応』、第2章「神経伝達物質」
    フジテクノシステム社 2004
Works (3)：
  • CREST 「高精度1分子内動画計測から見える生体分子構造認識プロセス」(代表 佐々木裕次) 「膜系1分子計測」
    2008 - 2011
  • 科学技術振興調整費 新興分野人材育成 「産総研ナノバイオ人材養成ユニット」 (代表 湯元昇)
  • 科学技術振興調整費 知的基盤整備 「創薬及び生物研究情報基盤としての生体内ペプチドの多角的データベース化に関する研究」 (代表 南野直人)
Education (5)：
  • Kyoto University Faculty of Engineering
  • Kyoto University Graduate School of Engineering
  • Kyoto University Graduate School of Medicine
  • Kyoto University
  • Kyoto University, Graduate School of Medicine and Faculty of Medicine
Professional career (1)：
  • PhD (Kyoto University)
Work history (14)：
  • 2020 - 現在 National Institute of Advanced Industrial Science and Technology
  • 2020/04 - 2022/03 Graduate School of Frontier Sciences, The University of Tokyo
  • 2013/04 - 2020/03 National Institute of Advanced Industrial Science and Technology (AIST) Molecular Profiling Research Center Deputy Director
  • 2007/04 - 2015/03 Gifu University United Graduate School of Drug Discovery and Medical Information Sciences Visiting Professor
  • 2010 - 2013 National Institute of Advanced Industrial Science and Technology (AIST) Evaluation Department Principal Reviewer
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Association Membership(s) (4)：
THE JAPANESE PEPTIDE SOCIETY ,  International Society on Toxinology ,  Biophysical Society ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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