Yokoo Hiroki

ヨコオヒロキ | Yokoo Hiroki

Affiliation and department：
Job title： Others

Research field (1)： Pharmacology

Research keywords (4)： inflammation , oxidative stress , Insulin receptor , Voltage-dependent Na<sup>+</sup> channel

Research theme for competitive and other funds (16)：

2019 - 2023 ケトン食が抗腫瘍免疫能を賦活化し、腫瘍の成長・予後を改善するメカニズム
2012 - 2015 Nox遺伝子制御が敗血症脳症の病態に果たす役割と治療標的としての意義
2011 - 2013 Potential therapeutic application of epigenetic mechanisms involved in the septic pathology
2009 - 2012 敗血症におけるインスリンシグナル調節機構の解明
2008 - 2010 The transcription factor AP-1 as a molecular target in sepsis therapy

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Papers (60)：

Samar Imbaby, Naoyuki Matsuda, Kengo Tomita, Kohshi Hattori, Sailesh Palikhe, Hiroki Yokoo, Yuichi Hattori. Beneficial effect of STAT-3 decoy oligodeoxynucleotide transfection on organ injury and mortality in mice with cecal ligation and puncture-induced sepsis. Scientific Reports. 2020. 10. 1. 15316-15316
Shigeyuki Yamashita, Tokiko Suzuki, Keisuke Iguchi, Takuya Sakamoto, Kengo Tomita, Hiroki Yokoo, Mari Sakai, Hiroki Misawa, Kohshi Hattori, Toshi Nagata, et al. Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis. Naunyn-Schmiedeberg's Archives of Pharmacology. 2018. 391. 9. 1-12
Masaaki Kawakami, Mizuki Hattori, Wakana Ohashi, Toshio Fujimori, Kohshi Hattori, Mariko Takebe, Kengo Tomita, Hiroki Yokoo, Naoyuki Matsuda, Mitsuaki Yamazaki, et al. Role of G protein-coupled receptor kinase 2 in oxidative and nitrosative stress-related neurohistopathological changes in a mouse model of sepsis-associated encephalopathy. Journal of Neurochemistry. 2018. 145. 6. 474-488
Qiang Wang, Hiroki Yokoo, Michinori Takashina, Kimimasa Sakata, Wakana Ohashi, Lobna A. Abedelzaher, Takahiro Imaizumi, Takuya Sakamoto, Kohshi Hattori, Naoyuki Matsuda, et al. Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages. CRITICAL CARE MEDICINE. 2015. 43. 11. E508-E520
Kimimasa Sakata, Takashi Kondo, Natsumi Mizuno, Miki Shoji, Hironobu Yasui, Tohru Yamamori, Osamu Inanami, Hiroki Yokoo, Naoki Yoshimura, Yuichi Hattori. Roles of ROS and PKC-beta II in ionizing radiation-induced eNOS activation in human vascular endothelial cells. VASCULAR PHARMACOLOGY. 2015. 70. 55-65

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MISC (42)：

Hiroki Yokoo, Qiang Wang, Lobna A. Abdelzaher, Michinori Takashina, Wakana Ohashi, Kimimasa Sakata, Takahiro Imaizumi, Takuya Sakamoto, Yuichi Hattori. The Ca2+ sensitizer levosimendan mitigates septic inflammation. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 105P-105P
Hiroki Yokoo, Kumiko Taguchi, Yuichi Hattori. The oligomerized polyphenol oligonol ameliorates high glucose- and TNF-alpha-induced NADPH oxidase activation and insulin signaling down-regulation in vascular endothelial cells. FASEB JOURNAL. 2013. 27
Mariko Takebe, Hirofumi Oishi, Aoki Yuta, Michinori Takashina, Kengo Tomita, Kumiko Taguchi, Hiroki Yokoo, Mitsuaki Yamazaki, Yuichi Hattori. Possible role of epigenetic modifications in the pathology of sepsis. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 105P-105P
Hiroki Yokoo, Seiji Yamamoto, Yuichi Hattori. Expression of TNF-R1 and Fas in coronary arterioles of type 2 diabetic mice. FASEB JOURNAL. 2012. 26
Kengo Tomita, Ken-ichi Takano, Michinori Takashina, Hiroki Yokoo, Yuichi Hattori. Endotoxin-induced acute lung inflammation is attenuated by intranasal NF-kappa B decoy oligonucleotides in mice. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 131P-131P

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Books (1)：

コメディカルのための薬理学第3版
朝倉書店 2018

Lectures and oral presentations (4)：

糖尿病と血管内皮 Death 受容体の発現(シンポジウム「糖尿病病態における血管内皮細胞機能研究の新しい展開」)
(第22回日本循環薬理学会)
脳神経細胞におけるインスリンシグナル:恒常性維持のためのシグナル変動脳神経細胞におけるインスリンシグナル:恒常性維持のためのシグナル変動
(第38回薬物活性シンポジウム)
神経障害治療への新戦略:インスリン受容体シグナル伝達分子の発現調節
(第34回薬物活性シンポジウム)
インスリン受容体シグナル伝達分子の発現調節機構(シンポジウム「神経系におけるインスリン・シグナリングとその役割)
(第77回日本薬理学会年会)

Education (2)：

1995 - 1999 Miyazaki Medical College
1985 - 1991 Miyazaki Medical College

Professional career (1)：

- (*Miyazaki Medical College*)

Work history (7)：

2014/09 - 現在 Tokoha University Faculty of Health Promotional Sciences, Department of Health and Nutritional Sciences
2007/10 - 2014/08 University of Toyama Graduate School of Medicine and Pharmaceutical Sciences for Research
2003/04 - 2007/03 University of Miyazaki Faculty of Medicine
2000/10 - 2003/03 Miyazaki Medical College
2000 - 2003 Research Associate, Miyazaki Medical College

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Committee career (1)：

該当なし

Association Membership(s) (2)：

日本麻酔学会 , 日本薬理学会

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