Nakamura Takeshi

Affiliation and department：
Homepage URL (1)： http://www.rs.noda.tus.ac.jp/~ribsnlab/index.html

Research field (2)： Medical biochemistry , Neuroscience - general

Research keywords (59)： Rab5 , 細胞運動 , 細胞増殖情報伝達系 , Akt , Ral , transformation , 分子時空間計測 , MEK , ERK , Rac , R-Ras , Rac1 , アポトーシス , Rapl , simulation , signal , イノシトールリン脂質 , Rhoファミリー低分子量Gタンパク質 , transduction , 低分子量G蛋白 , 小胞輸送 , タンパク質相互作用 , 細胞増殖 , セリンスレオニンキナーゼ , Asef , MAPK , Raf , 分子生物学 , 形態形成 , 統計解析 , システム生物学 , Ras , G蛋白 , 神経突起伸展 , 可視化 , 海馬神経細胞 , Rhoファミリー , 神経回路 , 細胞・組織 , フィードバック , 蛋白質 , 神経細胞 , Rho , 神経回路形成 , G蛋白質 , PIP_3 , Racl , 成長円錐 , RNAi , Rasファミリー , SHIP2 , 神経成長因子 , FRETプローブ , PI3キナーゼ , 神経科学 , イメージング , シミュレーション , シグナル伝達 , FRET

Research theme for competitive and other funds (17)：

2020 - 2023 Mechanism of G protein signals regulating bi-directional axon transport and axon growth, regeneration and degeneration
2015 - 2018 Analysis of molecular network regulating spatiotemporal activities of three G proteins that control membrane traffic during outgrowth of growth cones
2013 - 2016 Development of the Near-infrared Differential Laser-induced Surface Deformation Microscope and its Application to the Measurements on Rheological Properties of Single Living Cells
2010 - 2016 Multidimendional FRET imaging of intracellular signal transduction
2012 - 2012 Analysis of the regulation-mechanism of intracellular dynamics of late endosome and lysosome by using a FRET biosensor

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Papers (34)：

Shingo Koinuma, Ryota Negishi, Riko Nomura, Kazuki Sato, Takuya Kojima, Eri Segi-Nishida, Ryo Goitsuka, Yoichiro Iwakura, Naoyuki Wada, Yoshiki Koriyama, et al. TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous manner. Journal of neurochemistry. 2020. 157. 4. 1196-1206
Kanemitsu-Fujita, A, Morishita, S, Kjaer, S, Fukuda, M, Schiavo, G, Nakamura, T. Comparable affinity of RabGDIα for GTP- and GDP-bound forms of Rab7 supports a four-state transition model for Rab7 subcellular localization. bioRxiv. 2018. 287516
Shingo Koinuma, Kohei Takeuchi, Naoyuki Wada, Takeshi Nakamura. cAMP-induced activation of protein kinase A and p190B RhoGAP mediates down-regulation of TC10 activity at the plasma membrane and neurite outgrowth. GENES TO CELLS. 2017. 22. 11. 953-967
Yasuda, S, Morishita, S, Fujita, A, Nanao, T, Wada, N, Waguri, S, Schiavo, G, Fukuda, M, Nakamura, T. Mon1-Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells. J. Cell Sci. 2016. 129. 2. 329-340
Akane Fujita, Shingo Koinuma, Sayaka Yasuda, Hiroyuki Nagai, Hiroyuki Kamiguchi, Naoyuki Wada, Takeshi Nakamura. GTP Hydrolysis of TC10 Promotes Neurite Outgrowth through Exocytic Fusion of Rab11-and L1-Containing Vesicles by Releasing Exocyst Component Exo70. PLOS ONE. 2013. 8. 11. e79689

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MISC (12)：

Takeshi Nakamura, Akihiro Goto, Michiyuki Matsuda, Tatsuo Kinashi. Rap1B plays an instructive role in neuronal polarization through RalA and Nore1A in addition to PI3-kinase. NEUROSCIENCE RESEARCH. 2010. 68. E137-E137
Akihiro Goto, Takeshi Nakamura, Mikio Hoshino, Michiyuki Matsuda. FRET analysis of differences in signaling mechanism between dbcAMP- and NGF-induced neuritogenesis in PC12D cells. NEUROSCIENCE RESEARCH. 2010. 68. E249-E250
中村岳史, 北野正寛, 仲矢道雄, 長田重一, 松田道行. 【感染現象その理解の深化から疾患制御への展望】生体防御機構研究の新展開貪食過程における低分子量G蛋白質Rac1とRab5の活性変化. 蛋白質・核酸・酵素. 2009. 54. 8. 1114-1118
Akihiro Goto, Takeshi Nakamura, Michiyuki Matsuda. Differences in signaling mechanism and morphological change between dbcAMP- and NGF-induced neuritogenesis in PC12D cells. NEUROSCIENCE RESEARCH. 2009. 65. S45-S45
T. Nakamura, K. Aoki, M. Matsuda. FRET imaging and in silico analysis of nerve growth factor-induced neurite outgrowth. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE. 2008. 26. 8. 882-882

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Professional career (1)：

理学博士

Work history (7)：

2007 - 2010 京都大学生命科学研究科講師
2008 - 京都大学大学院・生命科学研究科講師
2007 - 京都大学大学院・医学研究科講師
2007 - 京都大学医学(系)研究科(研究院) 講師
2004 - 2006 Osaka University Research Institute for Microbial Diseases

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Association Membership(s) (4)：

BIOIMAGING SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR NEUROCHEMISTRY , THE JAPAN NEUROSCIENCE SOCIETY

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