Rchr

J-GLOBAL ID：200901089998486687 Update date: Apr. 22, 2024

Sokabe Masahiro

ソカベマサヒロ | Sokabe Masahiro

Affiliation and department：

Research field (6)： Clinical pharmacy , Physiology , Cell biology , Biophysics , Animals: biochemistry, physiology, behavioral science , Neuroscience - general

Research keywords (12)：シナプス可塑性 , 神経ステロイド , 接着斑 , 細胞骨格 , メカノセンサー , イオンチャネル , synaptic plasticity , neurosteroid , focal adhesion , cytoskeleton , mechanosensor , ion channel

Research theme for competitive and other funds (83)：

2022 - 2025 New function linkage between dietary protein and skeletal muscle via small intestine-derived exosomes
2019 - 2022 Mechano-nutrition-signaling for disuse muscle atrophy
2018 - 2021 Imaging analysis of mechno-sensing in mitochondria of living cells
2018 - 2021 Effective exercise to promote recovery from muscle atrophy
2015 - 2020 Mechanosensing Mechanisms for Sensing Mechanical Stress Including Gravitational Changes

2015 - 2018 Molecular rehabilitation of mitochondrial function towards preventing muscle atrophy

2015 - 2018 The effective training and the mechanisms for recovery from muscle atrophy

2013 - 2016 Search for mechanosensors underlying pathophysiology of respiratory diseases

2012 - 2016 Possible roles of actomyosin and mechanosensitive channels in substrate rigidity sensing of cells

2012 - 2015 Mitochondria is a key signal inducer for unloading stress toward muscle atrophy

2012 - 2015 Physical therapy to promote the recovery from muscle injury in rat

2012 - 2014 A study on a novel therapeutic strategy for Alzheimer's disease Using neurosteroids.

2011 - 2013 Structural changes in the actin filament associated with tension sensing

2010 - 2012 Therapeutic approach for respiratory diseases targeting TRP genes

2008 - 2012 細胞の基質堅さの感知機構に関する生物物理学的研究

2008 - 2012 Biophysical study on the substratum-rigidity sensing by cells

2010 - 2011 A study on the novel therapeutic drugs to protect delayed neuronal death after stroke

2009 - 2011 創傷治癒に対するプロテオグリカンの促進作用に関する研究

2009 - 2011 Study on the facilitative effects of proteoglycan on wound-healing

2009 - 2011 Actin filaments work as a negative tension sensor: elucidation of itsphysiochemical mechanism

2008 - 2011 Development of a comprehensive program to suppress muscle atrophy for elderly or patients who do not have the ability to do strength training

2007 - 2011 神経ステロイドを用いた脳卒中の新規治療法の開発

2007 - 2011 Development ofa novel therapy of stroke by neurosteroids

2005 - 2011 メカノセンサーとしてのアクチン線維の生物物理学的研究

2005 - 2011 Biophysical study on actin filament working as a mechanosensor

2004 - 2011 神経ステロイドによる学習記憶促進作用のシナプス/分子機構に関する研究

2004 - 2011 Study on the synaptic and molecular mechanisms in the facilitative effects of neurosteroids on leaning and memory

2003 - 2011 機械受容チャネルの構造機能連関に関する実験的/分子シミュレーション的研究

2003 - 2011 Experimental and molecular simulation study on the structure-function of mechanosensitive ion channels

2008 - 2010 Actin filaments function as a tension sensor via tension dependent binding of cofilin to the filament

2004 - 2008 Creation of Mechanobiology Based on Mechanosensitive Channels

2006 - 2007 Underling mechanisms of atrial fibrillation induced by atrial pressure/ volume overload, and new therapeutic approach for the management of atrial fibrillation

2005 - 2006 The actin filament as a mechno-sensing machinery

2003 - 2006 Analyses of activation mechanisms of cell mechanosensor at nano- and microlevels.

2004 - 2005 細胞骨格がメカノセンサーであることを検証する研究

2004 - 2004 SAチャネルの構造-活性連関と活性化における細胞骨格の役割解析

2002 - 2003 Molecular mechanism for the extension of neuronal growth cone : role of exocytosis of integrin.

2001 - 2003 STUDY ON THE STRUCTURE FUNCTION AND PHYSIOLOGICAL ROLES OF SA CHANNELS

2001 - 2001 高速単一細胞伸展装置の開発

2000 - 2000 聴覚神経細胞の神経成長円錐と有毛細胞の間の情報伝達の研究

2000 - 2000 伸展刺激による血管内皮細胞リモデリングの分子機構-インテグリン動態の解析-

1999 - 2000 Observation of erocytosis by near-field microscope

1999 - 1999 脳研究における生物物理学的アプローチの探索

1999 - 1999 伸展刺激による血管内皮細胞リモデリングの分子機構

1999 - 1999 近接場光を用いた生体機能分子の分子構造変化の観察と制御

1998 - 1999 CELL REMODELING BY MECHANICAL STIMULI : ROLE OF FOVAL ADHESION MOLECULES IN POLARITY FORMATION

1998 - 1998 脳研究における生物物理学的アプローチの探索

1998 - 1998 伸展刺激による血管内皮細胞リモデリングの分子機構

1998 - 1998 接着斑分子の動態とチロシン燐酸化のリアルタイムイメージング

1998 - 1998 近接場光を用いた生体機能高分子の分子構造変化の観察と制御

1997 - 1998 The observation of growth cones with advanced optical methods

1997 - 1998 STUDY ON THE DEVELOPMENT OF MOLECULAR BIOLOGY AND PHYSIOLOGY OF SA CHANNELS

1996 - 1998 1原子・1分子レベルの解析と操作による細胞膜機能の解明

1997 - 1997 脳研究における生物物理学的アプローチの探索

1997 - 1997 伸展刺激による血管内皮細胞リモデリングの分子機構

1997 - 1997 接着斑分子の動態とチロシン燐酸化のリアルタイムイメージング

1997 - 1997 機械受容チャネルの構造と機能:細胞体積調節における役割

1996 - 1997 STRETCH-INDUCED CELL MORPHOGENEISI : MOLECULAR MECHANISM OF DIRECTIONSENSITIVITY AND POLARITY FORMATION

1996 - 1996 機械受容チャネルの構造と機能

1995 - 1996 Imaging of dynamic structure of molecular and cellura organization by ultramicroscopic tequniques.

1995 - 1996 Joint Study on the Molecular Biology of SA Channels

1995 - 1995 機械受容チャネルの構造と機能

1994 - 1995 MOLECULAR MECHANISM OF MORPHOLOGICAL RESPONSE TO MECHANICAL STIMULI IN ENDOTHELIAL CELLS

1993 - 1995 PIONEERING RESEARCH ON THE DYNAMICAL ASPECT OF STRUCTURE-FUNTION RELATIONSHIP IN ION CHANNELS

1994 - 1994 メカノトランスダクションの分子機構

1993 - 1994 Joint Study on the Physiological Role of SA channel

1992 - 1992 細胞膜から核へのインフォメーションフローに関する総合的研究

1992 - 1992 血管内皮細胞における機械受容チャネルの研究

1992 - 1992 心筋イオンチャンネル

1991 - 1992 Screening of SA-channel mutant in Drosophila

1991 - 1992 Biophysical and Molecularbiological Study on Stretch Channel

1991 - 1991 血管内皮細胞における機械受容チャネルの研究

1991 - 1991 画像・電気信号マルチ計測による膜融合の微視的研究

1990 - 1991 Analysis of Functional Membrane Proteins by Planar Phospholiped Bilayers.

1990 - 1990 画像・電気信号マルチ計測による膜融合の微視的研究

1989 - 1990 Development of Ultra-high Power Video Microscope for Patch Clamp Study.

1989 - 1990 Quantitative Study of Stretch Channel Activation.

1989 - 1990 Inositol 1,4,5,-triphosphate activated Calcium Channels in oocytes.

1989 - 1989 画像・電気信号マルチ計測による膜融合の微視的研究

1987 - 1988 Reconstitution of phototransduction channel from frog rod outer segments in planar lipid bilayers

1986 - 1988 Mechano-receptor transduction channels in muscle spindle.

1986 - 1987 Identification of Na Ion Chennel Protein in Frog Rod Outer Segments.

1986 - 1986 膜における情報変換分子の作動機構

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Papers (190)：

Hiroki Katsuta, Satoru Okuda, Kazuaki Nagayama, Hiroaki Machiyama, Satoru Kidoaki, Masashi Kato, Masahiro Sokabe, Takaki Miyata, Hiroaki Hirata. Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers. iScience. 2023. 26. 3. 106090-106090
Masataka Nakano, Takuya Furuichi, Masahiro Sokabe, Hidetoshi Iida, Sachiko Yano, Hitoshi Tatsumi. Entanglement of Arabidopsis Seedlings to a Mesh Substrate under Microgravity Conditions in KIBO on the ISS. Plants. 2022. 11. 7. 956-956
Hiroaki Hirata, Masahiro Sokabe. Chapter 4. Measurement and Manipulation of Cellular Forces Using Silicone Elastomers. Biomaterials Science Series. 2022. 64-84
Masataka Nakano, Takuya Furuichi, Masahiro Sokabe, Hidetoshi Iida, Hitoshi Tatsumi. The gravistimulation-induced very slow Ca2+ increase in Arabidopsis seedlings requires MCA1, a Ca2+-permeable mechanosensitive channel. Scientific Reports. 2021. 11. 1
Kishio Furuya, Hiroaki Hirata, Takeshi Kobayashi, Masahiro Sokabe. Sphingosine-1-Phosphate Induces ATP Release via Volume-Regulated Anion Channels in Breast Cell Lines. Life. 2021. 11. 8. 851-851

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MISC (97)：

平田宏聡, 曽我部正博. Tension-dependent Generation of Biochemical Signals on Actomyosin Fibers. 生物物理(Web). 2020. 60. 2
Yoshitaka Nakayama, Ken ichi Hashimoto, Yasuyuki Sawada, Masahiro Sokabe, Hisashi Kawasaki, Boris Martinac. Corynebacterium glutamicum mechanosensitive channels: towards unpuzzling “glutamate efflux” for amino acid production. Biophysical Reviews. 2018. 10. 5. 1359-1369
三輪正人, 高田弘弥, 村上亮介, 大久保公裕, 古家喜四夫, 曽我部正博, 小川令. 圧刺激に対する粘膜上皮のCa2+オシレーション. 日本耳鼻咽喉科学会会報. 2018. 121. 4. 568-568
Hiroaki Hirata, Mukund Gupta, Sri Ram Krishna Vedula, Chwee Teck Lim, Benoit Ladoux, Masahiro Sokabe. Quantifying tensile force and ERK phosphorylation on actin stress fibers. Methods in Molecular Biology. 2017. 1487. 223-234
Sensing mechanisms of stretch and compression stimuli. 2016. 257. 10. 1001-1007

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Books (6)：

動物は何を考えているのか:学習記憶の比較生物学(曽我部正博編)
共立出版 2009
生物物理学とは何か:未解決問題への挑戦(曽我部正博、郷信宏編)
共立出版 2003
バイオイメージング(曽我部、臼倉編)
共立出版 1998
Towards Molecular Biophysics of Ion Channels. Sokabe M, Auerbach A, Sigworth F. (Eds)
Elsevier Sci BV Amsterdam, Netherland 1997
イオンチャネル(曽我部正博編)
共立出版 1997

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Works (4)：

科学技術振興機構国際共同発展研究(ICORP/SORST)細胞力覚プロジェクト「ナノ・マイクロ超分子複合体によるメカノトランスダクション機構の解明」
2004 - 2009
Cell Mechanosensing Project"Elucidation of the mechanotransduction mechanisms by nano- and micro-level spuramolecular complex"
2004 - 2009
JST国際共同研究(ICORP)細胞力覚プロジェクト
1999 - 2004
Cell Mechanosensing Project
1999 - 2004

Education (4)：

- 1975 Osaka University
- 1975 Osaka University Graduate School, Division of Engineering Science Biophysical Engneering
- 1973 Osaka University School of Engineering Science Direct Affiliates
- 1973 Osaka University Faculty of Engineering Science Dept of Biophysical Engineering

Professional career (1)：

Dr of Engineering (Osaka University)

Work history (1)：

Nagoya University Graduate School of Medicine, Cellular Information Medicine, Graduate School of Medicine Cell Information Medicine Professor,Others

Committee career (8)：

2007 - 2011 国際比較生理生化学会連合会長
2007 - 2011 International Association for Comparative Physiology and Biochemistry President
2006 - 2010 日本生理学会常任幹事
2006 - 2010 Physiological Society of Japan Senior Fellow
2008 - 2009 日本生物物理学会会長

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Association Membership(s) (10)：

国際比較生理生化学会連合 , 北米生物物理学会 , 日本比較生理生化学会 , 日本生理学会 , 日本生物物理学会 , International Association for Comparative Physiology and Biochemistry , Biophysical Society , Japanese Society for Comparative Physiology and Biochemistry , Physiological Society of Japan , Biophysical Society of Japan

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