Rchr
J-GLOBAL ID:200901090207216280
Update date: Nov. 01, 2024
Fujiyuki Tomoko
フジユキ トモコ | Fujiyuki Tomoko
Affiliation and department:
Job title:
Associate Professor
Research field (4):
Tumor diagnostics and therapeutics
, Laboratory animal science
, Virology
, Molecular biology
Research keywords (5):
viral vector
, oncolytic virus
, Microbiology
, Experimental animals
, Infectious diseases
Research theme for competitive and other funds (16):
- 2022 - 2026 癌治療用組換え麻疹ウイルスによる細胞死メカニズムと免疫誘導性の解析
- 2020 - 2025 ニパウイルスの野外迅速診断法確立とこれを用いた流行地域におけるウイルス性状の解析
- 2023 - 2025 麻疹ウイルスベクターを用いたニパウイルス感染症ワクチンの開発
- 2022 - 2023 麻疹ウイルスベクター用いた新型コロナウイルス感染症ワクチンの開発
- 2020 - 2023 遺伝子組換え麻疹ウイルスを用いた抗がんウイルス療法の臨床研究
- 2019 - 2023 Development of a Nipah measles vector vaccine (MV-NIV) to be used in outbreaks situation in children and adults exposed population
- 2021 - 2023 ウイルスを用いた新規癌治療法における癌細胞の応答機構解析
- 2018 - 2021 癌治療用組換え麻疹ウイルスによる細胞死誘導機構の解析
- 2016 - 2019 Molecular basis underlying anti-tumor activity of an oncolytic measles virus
- 2014 - 2017 Development of measles virus vector-based vaccine against highly pathogenic avian influenza virus
- 2011 - 2012 Analysis of intracellular trafficking of membrane proteins of Nipah virus
- 2009 - 2011 カイコを利用したRNAウイルス感染症治療薬の開発および感染の分子機構の解明に関する研究
- 2009 - 2011 Analysis of propagation manners of paramyxoviruses in neural cells.
- 2009 - 2010 カイコを利用したヒト病原性RNAウイルス感染モデルの開発
- 2005 - 2008 ウイルス感染がミツバチの攻撃行動に及ぼす分子神経学的解析
- 2002 - 2004 ミツバチの攻撃行動を規定する遺伝子の同定と解析
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Papers (36):
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Tomoyuki Nanamiya, Kiyoko Takane, Kiyoshi Yamaguchi, Yuya Okawara, Mariko Arakawa, Akari Saku, Tsuneo Ikenoue, Tomoko Fujiyuki, Misako Yoneda, Chieko Kai, et al. Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS. Oncology reports. 2024. 51. 1
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Kei Tamura, Tomoko Fujiyuki, Kanako Moritoh, Hayato Akimoto, Keigo Iizuka, Hiroki Sato, Kazushi Asano, Misako Yoneda, Chieko Kai. Anti-tumor activity of a recombinant measles virus against canine lung cancer cells. Scientific reports. 2023. 13. 1. 18168-18168
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Kanako Moritoh, Koichiro Shoji, Yosuke Amagai, Tomoko Fujiyuki, Hiroki Sato, Misako Yoneda, Chieko Kai. Immune response elicited in the tumor microenvironment upon rMV-SLAMblind cancer virotherapy. Cancer science. 2023
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Kei Tamura, Kumiko Ishigaki, Orie Yoshida, Terai Kazuyuki, Naoki Sakurai, Tatsuya Heishima, Tomoko Fujiyuki, Chieko Kai, Kazushi Asano. Gene expression of Nectin-4 and its clinical significance in dogs with primary lung adenocarcinoma. Veterinary medicine and science. 2022
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Hiroki Sato, Miho Hoshi, Fusako Ikeda, Tomoko Fujiyuki, Misako Yoneda, Chieko Kai. Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase. PLoS pathogens. 2021. 17. 10. e1009841
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MISC (25):
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甲斐知惠子, 藤幸知子, 米田美佐子. 麻疹ウイルスを用いたウイルス療法. Precision Medicine. 2024. 7. 28-31
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Tomoko Fujiyuki, Koichiro Shoji, Keigo Iizuka, Yu Horikirizono, Hiroki Sato, Kazushi Asano, Misako Yoneda, Chieko Kai. Potential applicable range of oncolytic virotherapy with a recombinant measles virus in dogs. CANCER SCIENCE. 2018. 109. 1037-1037
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Chieko Kai, Tomoko Fujiyuki, Hiroki Sato, Yataro Daigo, Misako Yoneda. Applicability of a recombinant SLAM-blind measles virus to breast cancer treatment. CANCER SCIENCE. 2018. 109. 274-274
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T. Fujiyuki, Y. Amagai, K. Shoji, A. Sugai, M. Awano, H. Sato, M. Yoneda, C. Kai. An oncolytic recombinant measles virus is a candidate of a novel therapeutic agent for triple negative breast cancer. HUMAN GENE THERAPY. 2017. 28. 12. A5-A5
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C. Kai, T. Fujiyuki, K. Shoji, H. Sato, M. Yoneda. Development of oncolytic measles virus, rMV-SLAMblind. HUMAN GENE THERAPY. 2017. 28. 12. A25-A25
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Books (2):
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遺伝子治療開発研究ハンドブック
エヌ・ティー・エス 2023 ISBN:9784860438401
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Epidemiology of Kakugo Virus, An Insect Picorna-like Virus Identified in Aggressive Honeybee Workers -- A Study of Virus-host Interactions in the Honeybee Society : In Insect Viruses: Detection, Characterization and Roles.
Nova Science Publishers Inc. 2009
Lectures and oral presentations (12):
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ウイルスを利用した新しい医療用ツールの開発
(名古屋大学GTRセミナー 2024)
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腫瘍溶解性遺伝子組換え麻疹ウイルス、rMV-SLAMblind、を利用した新規がん治療法の開発
(第96回日本生化学会大会、シンポジウム「多様な病原体研究が生み出す新たな生化学領域」(オーガナイザー:宮崎真也、藤幸知子) 2023)
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癌治療用麻疹ウイルスの難治性乳がんに対する効果
(医療工学研究会2021年度公開ワークショップ「麻疹ウイルスを利用した次世代癌治療法の開発」 2022)
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弱毒化麻疹ウイルスを利用した医療用ベクターの開発-アカデミア発新薬開発の現状と課題-
(東京大学大学院理学系研究科生物科学セミナー 2021)
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An oncolytic recombinant measles virus is a candidate of a novel therapeutic agent for triple negative breast cancer.
(XXVth European Society of Gene & Cell Therapy 2017)
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Education (3):
- 2002 - 2005 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Biology
- 2000 - 2002 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Pharmaceutical Biology
- 1998 - 2000 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1):
- PhD (The University of Tokyo)
Work history (9):
- 2024/10 - 現在 Teikyo University Advanced Comprehensive Research Organization
- 2020/10 - 2024/09 The University of Tokyo Institute of Industrial Science Project Associate Professor
- 2019/04 - 2020/10 The University of Tokyo Institute of Industrial Science
- 2012/05 - 2019/03 The University of Tokyo The Institute of Medical Science Assistant Professor
- 2011/04 - 2012/04 The University of Tokyo The Institute of Medical Science Postdoc
- 2009/04 - 2011/03 The University of Tokyo Graduate School of Pharmaceutical Sciences
- 2005/04 - 2009/03 The University of Tokyo Graduate School of Science, Department of Biological Sciences
- 2006/04 - 2006/10 Wuerzburg Universitaet BeeGroup Guest researcher
- 2002/04 - 2005/03 The University of Tokyo Graduate School of Science, Department of Biological Sciences
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Committee career (2):
- 2022 - 現在 PLoS ONE Academic Editor
- 2021 - 現在 Drug Discovries & Therapeutics Editorial Board
Awards (3):
- 2016 - The Molecular Biology Society of Japan Poster award
- 2016 - The Japanese Society for Virology Best poster award
- 2008 - Japan-China joint medical workshop on drug discoveries and therapeutics 2008 International medical communication Young award
Association Membership(s) (6):
THE JAPANESE CANCER ASSOCIATION
, JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
, 日本ウイルス学会
, 日本分子生物学会
, 日本ウイルス療法学会
, 日本生化学会
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