Rchr
J-GLOBAL ID：200901090699096218   Update date: Nov. 26, 2024

Shimizu Makiko

シミズ マキコ | Shimizu Makiko
Affiliation and department：
Showa Pharmaceutical University Faculty of Pharmaceutical Sciences, Department of Bio-Pharmacy, Laboratory of Drug Metabolism and Pharmacokinetics

About Showa Pharmaceutical University Faculty of Pharmaceutical Sciences, Department of Bio-Pharmacy, Laboratory of Drug Metabolism and Pharmacokinetics


Research field  (3)： Clinical pharmacy ,  Pharmacology ,  Pharmaceuticals - health and biochemistry
Research keywords  (2)： Drug Metabolism ,  薬物代謝
Research theme for competitive and other funds  (3)：
  • 1998 - フェノール系薬物に対する薬物代謝酵素の反応性とその変動要因に関する研究
  • ヒト型薬物代謝酵素の多型性に関する研究
  • Study of genetic pdymorphism of drug metabolizing enzymes.
Papers (62)：
  • Makiko Shimizu, Miaki Makiguchi, Yasuhiro Uno, Hiroshi Yamazaki. Quinuclidine N-Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs. Drug Metabolism and Disposition. 2024. 52. 8. 906-910
  • Yasuhiro Uno, Miaki Makiguchi, Genki Ushirozako, Kyoko Tsukiyama-Kohara, Makiko Shimizu, Hiroshi Yamazaki. Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 2024. 277
  • Koichiro Adachi, Tsubasa Sasaki, Atsuo Arai, Makiko Shimizu, Hiroshi Yamazaki. Impact of variability of <i>in silico</i> and <i>in vitro</i> octanol/water partition coefficients of compounds on the input parameters and results of simplified human physiologically based pharmacokinetic models after virtual oral administrations. The Journal of Toxicological Sciences. 2024. 49. 10. 459-466
  • Koichiro Adachi, Maki Murata, Akiyoshi Inada, Takeyori Morimoto, Makiko Shimizu, Satoru Beppu, Hiroshi Yamazaki. Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman. Acute medicine & surgery. 2024. 11. 1. e985
  • Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Norie Murayama, Makiko Shimizu, Yoshiro Saito, Hiroshi Yamazaki. Modeled Hepatic/Plasma Exposures of Omeprazole Prescribed Alone in Cytochrome P450 2C19 Poor Metabolizers Are Likely Associated with Hepatic Toxicity Reported in a Japanese Adverse Event Database. Biological & pharmaceutical bulletin. 2024. 47. 5. 1028-1032
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MISC (30)：
  • Yasuhiro Uno, Makiko Shimizu, Hiroshi Yamazaki. A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models. Biochemical Pharmacology. 2024. 228
  • 安達昂一郎, 清水万紀子, 庄野文章, 船津公人, 山崎浩史. Octanol/water partition coefficients determined in a reverse-phase liquid chromatography as a determinant factor for pharmacokinetic parameter estimations of chemical substances. 日本薬学会年会要旨集(Web). 2024. 144th
  • 安達昂一郎, 清水万紀子, 田中敏博, 山崎浩史. Pharmacokinetics of acetaminophen in a self-administrated overdose in an adolescent girl. 日本薬学会年会要旨集(Web). 2023. 143rd
  • Makiko Shimizu, Hiroshi Yamazaki. GENETIC POLYMORPHISMS IN FLAVIN-CONTAINING MONOOXYGENASE 3 (FMO3) GENE RESPONSIBLE FOR TRIMETHYLAMINURIA IN A JAPANESE POPULATION. DRUG METABOLISM REVIEWS. 2015. 47. 213-213
  • Hiroshi Yamazaki, Hiroshi Suemizu, Ai Tsukada, Shigeto Sota, Norie Murayama, Ryohji Takano, Makiko Shimizu, Masato Nakamura. METABOLISM AND DISPOSITION OF MELENGESTROL ACETATE IN HUMANS EXTRAPOLATED FROM THE PHARMACOKINETICS IN CHIMERIC MICE WITH HUMANIZED LIVER AND PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING. DRUG METABOLISM REVIEWS. 2014. 45. 234-234
ｍore...
Professional career (1)：
  • 博士(薬学)
Association Membership(s) (2)：
日本薬学会 ,  日本薬物動態学会
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