Shimizu Makiko

シミズマキコ | Shimizu Makiko

Affiliation and department：

Research field (3)： Clinical pharmacy , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (2)： Drug Metabolism , 薬物代謝

Research theme for competitive and other funds (3)：

1998 - フェノール系薬物に対する薬物代謝酵素の反応性とその変動要因に関する研究
ヒト型薬物代謝酵素の多型性に関する研究
Study of genetic pdymorphism of drug metabolizing enzymes.

Papers (49)：

Koichiro Adachi, Makiko Shimizu, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki. Octanol/water partition coefficients estimated using retention times in reverse-phase liquid chromatography and calculated in silico as one of the determinant factors for pharmacokinetic parameter estimations of general chemical substances. The Journal of toxicological sciences. 2024. 49. 4. 127-137
Makiko Shimizu, Shotaro Uehara, Katsuhiro Ohyama, Haruka Nishimura, Yoichi Tanaka, Yoshiro Saito, Hiroshi Suemizu, Sayaka Yoshida, Hiroshi Yamazaki. Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated andN-Demethylated Metabolitesin Pediatric Patients Genotyped for CytochromeP450 2D6. Drug Metabolism and Disposition. 2023. DMD-AR
Koichiro Adachi, Masayoshi Utsumi, Tasuku Sato, Hina Nakano, Makiko Shimizu, Hiroshi Yamazaki. Modeled Rat Hepatic and Plasma Concentrations of Chemicals after Virtual Administrations Using Two Sets of in silico Liver-to-Plasma Partition Coefficients. Biological & pharmaceutical bulletin. 2023
Koichiro Adachi, Hina Nakano, Tasuku Sato, Makiko Shimizu, Hiroshi Yamazaki. Liver and Plasma Concentrations of Food Chemicals after Virtual Oral Doses Extrapolated Using in silico Estimated Input Pharmacokinetic Parameters to Confirm Reported Liver Toxicity in Rats. Biological & pharmaceutical bulletin. 2023
Koichiro Adachi, Katsuhiro Ohyama, Yoichi Tanaka, Hina Nakano, Tasuku Sato, Norie Murayama, Makiko Shimizu, Yoshiro Saito, Hiroshi Yamazaki. Plasma and Hepatic Exposures of Celecoxib and Diclofenac Prescribed Alone in Patients with Cytochrome P450 2C9*3 Modeled after Virtual Oral Administrations and Likely Associated with Adverse Drug Events Reported in a Japanese Database. Biological & pharmaceutical bulletin. 2023. 46. 6. 856-863

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MISC (29)：

安達昂一郎, 清水万紀子, 庄野文章, 船津公人, 山崎浩史. Octanol/water partition coefficients determined in a reverse-phase liquid chromatography as a determinant factor for pharmacokinetic parameter estimations of chemical substances. 日本薬学会年会要旨集(Web). 2024. 144th
安達昂一郎, 清水万紀子, 田中敏博, 山崎浩史. Pharmacokinetics of acetaminophen in a self-administrated overdose in an adolescent girl. 日本薬学会年会要旨集(Web). 2023. 143rd
Makiko Shimizu, Hiroshi Yamazaki. GENETIC POLYMORPHISMS IN FLAVIN-CONTAINING MONOOXYGENASE 3 (FMO3) GENE RESPONSIBLE FOR TRIMETHYLAMINURIA IN A JAPANESE POPULATION. DRUG METABOLISM REVIEWS. 2015. 47. 213-213
Hiroshi Yamazaki, Hiroshi Suemizu, Ai Tsukada, Shigeto Sota, Norie Murayama, Ryohji Takano, Makiko Shimizu, Masato Nakamura. METABOLISM AND DISPOSITION OF MELENGESTROL ACETATE IN HUMANS EXTRAPOLATED FROM THE PHARMACOKINETICS IN CHIMERIC MICE WITH HUMANIZED LIVER AND PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING. DRUG METABOLISM REVIEWS. 2014. 45. 234-234
Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, Hiroshi Yamazaki. Drug interactions of thalidomide with midazolam in human hepatoma cell line system with differentiated HepaRG cryopreserved. DRUG METABOLISM REVIEWS. 2011. 43. 60-60

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Professional career (1)：

博士(薬学)

Association Membership(s) (2)：

日本薬学会 , 日本薬物動態学会

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