Unno Hideaki

ウンノヒデアキ | Unno Hideaki

Affiliation and department：
Homepage URL (1)： http://www.cms.nagasaki-u.ac.jp/lab/seitai/

Research field (2)： Applied biochemistry , Structural biochemistry

Research keywords (7)：構造生物学 , 海産無脊椎動物 , 酵素 , Transporter , Lectin , X線結晶構造解析 , Protein Crystallography

Research theme for competitive and other funds (15)：

2022 - 2025 AMPDの結晶構造解析による反応機構の解明
2020 - 2023 Creation of microbial cells as the innovative chassis for isoprenoid production
2017 - 2020 Elucidation of novel functions of marine invertebrate lectins based on their structural diversity and its application
2015 - 2018 structural and functional analyses of novel lectins from marine invertebrates, and its application.
2014 - 2017 Development of EGFR-Tyrosine Kinase Inhibitors Effective for Non-Small Cell Lung Cancer Resistant to Gefitinib

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Papers (54)：

Kazuhiro Ohara, Yasuhiro Oshima, Hideaki Unno, Satoru Nagano, Masami Kusunoki, Seiji Takahashi, Toshiyuki Waki, Satoshi Yamashita, Toru Nakayama. Lowering pH optimum of activity of SshEstI, a slightly alkaliphilic archaeal esterase of the hormone-sensitive lipase family. Journal of bioscience and bioengineering. 2024
Tomomitsu Hatakeyama, Fuki Kojima, Issei Ohkawachi, Hitomi Sawai, Hideaki Unno. Carbohydrate-binding ability of a recombinant protein containing the DM9 motif from Drosophila melanogaster. The Journal of Biochemistry. 2024
Tomomitsu Hatakeyama, Kazuki Masuda, Mizuki Kudo, Koshi Tanaka, Ayaka Takeuchi, Hideaki Unno. Mannose oligosaccharide recognition of CGL1, a mannose-specific lectin containing DM9 motifs from Crassostrea gigas, revealed by X-ray crystallographic analysis. Journal of biochemistry. 2023. 175. 1. 35-41
Tomomitsu Hatakeyama, Hideaki Unno. Functional Diversity of Novel Lectins with Unique Structural Features in Marine Animals. Cells. 2023. 12. 14. 1814-1814
Hatakeyama, T., Kishigawa, A., Unno, H. Molecular cloning and characterization of the two putative toxins expressed in the venom of the devil stinger Inimicus japonicus. Toxicon. 2021. 201. 9-20

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MISC (14)：

小嶋芙季, 澤井仁美, 海野英昭, 畠山智充. 無脊椎動物の自然免疫に関与するDM9ドメインタンパク質の構造と糖結合活性. 日本生化学会大会(Web). 2023. 96th
海野英昭. 無脊椎動物由来溶血性レクチンの細胞膜孔形成機構 CEL-IIIによる膜孔形成メカニズム. 化学と生物. 2015. 53. 2. 74-75
邊見久, 長井拓也, 海野英昭, 吉村徹. 1-IV-3 不可逆阻害剤となる基質アナログを用いたタイプ2イソペンテニル二リン酸イソメラーゼの反応機構解析(一般演題要旨,日本ビタミン学会第63回大会講演要旨). ビタミン. 2011. 85. 4. 226-226
Hideaki Unno, Tomomitsu Hatakeyama, Takuro Kamiya, Masami Kusunoki, Sachiko Nakamura-Tsuruta, Jun Hirabayashi, Shuichiro Goda. Crystal structure of CEL-IV, isolated from a sea cucumber, cucumaria echinata. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES. 2011. 67. C547-C547
海野英昭. C. echinata由来溶血性レクチンCEL-IIIの膜孔形成複合体結晶構造解析. 研究助成金受給者研究報告集. 2011. 30. 63-67

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Books (3)：

Lectin Purification and Analysis : Methods and Protocols (Methods in Molecular Biology (2132))
Springer US 2020
Flavins and Flavoproteins 2011
Lulu.com 2013
構造生物学 -ポストゲノム時代のタンパク質研究-
共立出版 2007

Lectures and oral presentations (4)：

Education (1)：

Professional career (1)：

Work history (7)：

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Association Membership(s) (3)：

THE JAPANESE BIOCHEMICAL SOCIETY , PROTEIN SCIENCE SOCIETY OF JAPAN , THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN

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