YOSHIMURA Yoshitaka

2019 - 2022 G-CSFは薬剤関連顎骨壊死を救えるのか?-マウスによる検討

2017 - 2020 歯牙種発症に関しての研究

2016 - 2020 歯根膜組織の再生・恒常性維持マシナリーに関与する新機能の探索および応用法の開発

2017 - 2019 骨吸収抑制剤の休薬は顎骨壊死発症の予防に有効か?マウスによる検討

2016 - 2019 造血因子によるMedication-related顎骨壊死治療の検討

2014 - 2017 幹細胞のニッチに注目した顎骨再建法の開発

2014 - 2017 乳歯歯髄由来間葉系幹細胞の骨芽細胞分化機転の解明

2013 - 2016 歯周組織の恒常性維持機構における歯根膜機能の解析および新しい歯周組織再建法の開発

2013 - 2016 アセチルサリチル酸によるBRONJ発症の予防法の開発

2012 - 2015 顎裂部骨移植における幹細胞を用いた骨組織再生療法の試み-造血系幹細胞の併用-

2012 - 2014 多発性歯牙腫を有している患者における原因因子の検索

2011 - 2014 免疫担当細胞を標的とした新たなBRONJ治療法の開発

2010 - 2013 重度歯周病罹患歯の残存歯根膜を根面に増殖させた歯とBMPの移植による歯周組織再生

2010 - 2012 A development of the bonding treatment of vertically fractured roots with periodontal regeneration adhesive resin using tissue engineering

2010 - 2012 Analysis of pathological and/or unphysiological root resorption mechanism focused on the two types of osteoclasts

2009 - 2012 Mechanisms of salivary gland atrophy induced by soft food

2009 - 2011 Study of evolution of osteoclasts regulating factors in teleost fish

2009 - 2011 Immunological approaches to the mechanisms of bisphosphonate-related osteonecrosis of the jaw

2009 - 2011 The research for the niche factor of stem cells in culture condition

2007 - 2009 Periodontal regeneration after implantation BMP and teeth with cells on the root planed surface populating from periodontal ligament in vitro

2007 - 2008 Analysis of the tooth eruption viaregulation of transcription factor

2006 - 2008 Osteoimmunological analysis of pathological and/or unphysiologicalroot resorption in deciduous teeth involvement of T lymphocyte

2006 - 2007 Study of odontotherapy rerated-osteonecrosis of the jaw following to long-term bisphosphonate application

2005 - 2006 The analysis of the network transcription regulation by the IKK・r in the tooth differentiation and development.

2005 - 2006 Development of a new periodontal regeneration technique for the teeth with reduced periodontal ligament using the combination of tissue culture and transplantation of the teeth

2005 - 2006 RNAiを用いた自然免疫系制御による硬化性骨髄炎の治療戦略

2004 - 2005 Mechanism of condensing osteitis crisis following viral infection through toll-like receptors

2004 - 2005 骨再生を目指した転写因子Osterixの機能調節機構の解明

2005 - 各種MHCクラスI/ペプチド複合体とT細胞レセプターとの反応速度論的解析

2002 - 2004 乳歯歯根吸収の制御を目的とした遺伝子治療のための基礎的研究

2002 - 2004 The reaction mechanism of general anesthetics studied by electron spin resonance and fluorescence measurement technique

2004 - 移植免疫における副組織適合抗原認識機構の解明

2003 - 2003 遺伝子治療による新しい歯根吸収制御法の開発

2002 - 2003 The identification of genes associated with the root resorption of deciduous tooth and molecular biology analysis of control mechanism.

2000 - 2002 Interaction of osteoclasts and cancer cells in the process of bone invation of oral cancer

1999 - 2001 Approach to reaction mechanism of general anesthetics by biological and physicochemical methods from new viewpoint

1999 - Graft-versus-host disease (GvHD) in bone marrow recipients

1997 - 1998 新しい視点からの麻酔薬の作用および副作用の機序の解明と新規麻酔薬評価への応用

1996 - 1998 口腔癌発癌過程における転写因子RB蛋白質の関与に関する研究

1995 - 1997 Study on transcription factor NF-kB regulating the gene function of tyrosin kinase in osteoblast

1994 - 1994 骨形成細胞の石炭化におけるアルカリ性ホスファターゼの生理的役割の解明-異なる培養条件を用いて-

1992 - 1994 Study on the function and regulation of gene coding tyrosine kinase

1992 - 1994 Establishment of a osteoblastic cell line derived from calvarial of rat embryo.

1993 - 1993 石灰化過程及び低カルシウム環境下でのアルカリ性ホスファターゼの生理的役割の解明

1992 - 1992 低カルシウム環境下における骨由来細胞のアルカリ性ホスファターゼの生理的役割の解明

1990 - effect of mechanical stress on cultured cells

1990 - bone formation and resorpsion