Goto Koichi

• 2022 - 2025 Induction Effects of Mesoporous Silica Nanoparticles on Vaccine Immunity
• 2018 - 2021 メソポーラスシリカナノ粒子を用いたがんワクチン創出に関する研究
• 2013 - 2017 複合リポソームを用いたがんワクチン療法に関する基礎研究
• 2013 - 2016 Medical technological study of nano chemotherapy using hybrid liposomes for the refractory disease
• 2011 - 2014 Development of research with liposomes toward clinical application for cancer and AIDS
2012 - 2013 焼酎蒸留粕の医療工学的応用に関する基礎研究
2008 - 2012 Antitumor mechanism in molecular model with relation to fluctuation of tumor cell membranes and liposomes
2009 - 2011 Development of Novel Vaccine Using Hybrid Liposomes for Cancer Therapy
2008 - 2010 Control of Interface in Cancer Cell Membranes and Inhibitory Effects of Three-component Hybrid Liposomes Including Sugar Surfactant
2008 - 2010 Development of Nanotherapy System for Intractable Disease with Hybrid Liposomes-Cancer therapy with hybrid liposomes-
2007 - 2009 腫瘍免疫を誘導増強する複合脂質膜の創製に関する研究
2007 - 2008 Hybrid liposomes enhancing the antitumor immunity and their applications to cancer therapy
2006 - 2007 複合脂質膜のがん細胞膜をターゲットとする治療効果と分子レベルでの解明
2005 - 2006 Synthesis of chiral calixarenes and application as functional organic catalysts
2000 - 2000 アポトーシス誘導複合脂質膜の制がん効果
1999 - 2000 カリックスアレーンを有機触媒に用いる新規不斉反応系の開発
1999 - 1999 複合脂質膜のがん抑制メカニズムと臨床への応用
1998 - 1998 複合脂質膜のがん抑制メカニズムと臨床への応用
Application of Calixarenes as an organic catalyst in Asymmetric Reactions
Study on Physical Properties of the Hybrid-Type Artificial Membranes and Steric Control for the Enantioselective Hydrolysis

• M. Okumura, H. Ichihara, K. Goto, Y. Matsumoto. Dried Seaweed (Porphyra yezoensis) Extract Promotes Fat Metabolism in Fatty Liver Cell and Mouse Models. Journal of Food and Nutritional Disorders. 2021. in press
• H. Ichihara, M. Okumura, T. Doi, T. Inano, K. Goto, Y. Matsumoto. Cancer Therapeutic and Preventive Effects of Dried Seaweed (Porphyra yezoensis) Extract by Gut Immunity Activation. Journal of Food and Nutritional Disorders. 2020. 19. 1. p1000270-1-p1000270-6
• Jie Lu, Kohei Yoshimura, Koichi Goto, Craig Lee, Ken Hamura, Ohyun Kwon, Fuyuhiko Tamanoi. Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells. PLOS ONE. 2015. 10. 9. e0137595
• Yuji Komizu, Toshiko Ueoka, Koichi Goto, Ryuichi Ueoka. Immunostimulation Effects of Powder from Barely-Shochu Distillation Remnants on a Human Natural Killer Cell Line in Vitro. KAGAKU KOGAKU RONBUNSHU. 2014. 40. 5. 438-442
• 古水雄志, 上岡利子, 後藤浩一, 上岡龍一. 麦焼酎粕パウダーのヒトナチュラルキラー株化細胞に対するin vitroでの免疫賦活効果. 化学工学論文集. 2014. 40. 5. 438-442

ｍore...

• Y Kadota, C Taniguchi, S Masuhara, S Yamamoto, S Furusaki, M Iwahara, K Goto, Y Matsumoto, R Ueoka. Inhibitory effects of extracts from peels of Citrus natsudaidai encapsulated in hybrid liposomes on the growth of tumor cells in vitro. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2004. 27. 9. 1465-1467
• K Nakashima, M Miyagi, K Goto, Y Matsumoto, R Ueoka. Enzymatic and hyperglycemia stability of chemically modified insulins with hydrophobic acyl groups. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2004. 14. 2. 481-483
• Osamu Tanoue, Hideaki Ichihara, Koichi Goto, Yoko Matsumoto, Ryuichi Ueoka. Steric-control for the enantioselective hydrolysis of amino acid esters in hybrid membrane systems. Chemical and Pharmaceutical Bulletin. 2003. 51. 2. 224-226
• Y Yano, K Shimada, J Okai, K Goto, Y Matsumoto, R Ueoka. Fairly marked enantioselectivity for the hydrolysis of amino acid esters by chemically modified enzymes. JOURNAL OF ORGANIC CHEMISTRY. 2003. 68. 4. 1314-1318
• K Goto, Y Yano, E Okada, CW Liu, K Yamamoto, R Ueoka. Catalytic specificity exhibited by p-sulfonatocalix[n]arenes in the methanolysis of N-acetyl-L-amino acids. JOURNAL OF ORGANIC CHEMISTRY. 2003. 68. 3. 865-870

ｍore...

• MSN Vaccines for Immunotherapy toward Cancer
  (12th International Symposium on Nanomedicine 2018)
• 担がんマウスに対する海苔抽出物の免疫賦活効果によるがん治療効果
  (第77回日本癌学会学術総会 2018)
• 海苔(Porphyra yezoensis)抽出物のin vitroおよびin vivoにおける免疫賦活効果
  (第72回日本癌学会学術総会 2013)
• Hybrid Liposomes Inhibit Tumor Growth and Lung Metastasis of Murine Osteosarcoma Cells
  (Hybrid Liposomes Inhibit Tumor Growth and Lung Metastasis of Murine Osteosarcoma Cells”, The 6th International Symposium on Molecular Science of Fluctuations toward Biological Functions 2012)
• Anti-Cancer Effects of Residual Powder from Shochu Distillation Remnants against Hepatocellular Carcinoma
  (第70回日本癌学会学術総会 2011)

ｍore...

• 1992 - 1995 熊本工業大学大学院 工学研究科 応用化学専攻 博士課程
• 1990 - 1992 熊本工業大学大学院 工学研究科 応用化学専攻 修士課程
• 1986 - 1990 熊本工業大学 工学部 工業化学科

• Engineering (Kumamoto Institute of Technology (current name Sojo University))

• 2011 - 現在 Sojo University Professor
• 2003 - 2011 - 崇城大学(旧 熊本工業大学) 助教授
• 2003 - 2011 - Associate Professor, Faculty of Engineering, Sojo University (former name: Kumamoto Institute of Technology)
• 1997 - 2003 Lecturer, Faculty of Engineering, Kumamoto Institute of Technology
• 1996 - 2003 熊本工業大学 講師
1995 - 1997 Research Assistant, Faculty of Engineering, Kumamoto Institute of Technology
1995 - 1996 熊本工業大学 助手
1995 - 新技術事業団 研究員
1995 - Researcher, Research Development Corporation of Japan

有機合成化学協会 ,  化学工学会 ,  日本化学会 ,  The Society of Synthetic Organic Chemistry, Japan ,  The Society of Chemical Engineers, Japan ,  The Chemical Society of Japan ,  Japan Nanomedicine Society ,  THE JAPANESE CANCER ASSOCIATION ,  THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER