2018 - 2021 Identification of causative bacteria for ulcerative colitis by using model mice and Maldi mass-spectrometer.
2015 - 2018 Development of cancer immunotherapy using tumor-associated antigen-derived long peptides and liberation from immune suppression mediated trough IL-6 signaling
2014 - 2017 Identification and analyses of colitis-associated gene segment using colitis-model mice by CRISPR/Cas9 system.
2013 - 2017 Investigation of cancer promotion by a cancer microenvironment factor C5a and establishment of the therapy targeting the C5a-C5a receptor system.
2014 - 2016 Study of the mechanism of malignancy increase in heterogeneous cancer by using integrated proteomics and mouse models
2012 - 2015 Development of new cancer immunotherapy aiming activation of both anti-tumor killer and helper T cells
2010 - 2015 Analysis of HLA class I/II binding peptides and binding motifs and its application for cancer immunotherapy
2011 - 2013 Development of a detection system for metastatic oral cancer by combining integrated proteomics with cancer histology analysis
2011 - 2013 Identification of substrate molecules on the host immune cells of bacterial proteases by using radioisotopes and mass spectrometry.
2010 - 2012 Analysis of gingipains target molecule of the white corpuscle cell surface by radioactivity mark and proteomics.
2010 - 2012 Investigation and therapeutic application of the cancerauto-activation pathway through generation of anaphylatoxin C5a
2010 - 2012 Study of the molecular mechanism of neural tumor formation mediatedby NF1 gene deficiency
2008 - 2010 Identification of kinase substrates by using radioactive ATP and LC-Maldi-MS/MS
2008 - 2008 cDNAマイクロアレイ解析を用いた新規癌特異抗原の探索と臨床応用
2005 - 2006 ES細胞から分化誘導した樹状細胞を用いた免疫制御機構の解明と免疫療法の開発
2005 - 2006 Analyses for protein kinase D2 substrate using 2D-DIGE and Q-Trap mass-spectrometer.
2004 - 2005 The development of immuno-modulation therapy by use of ES cell-derived dendritic cells
2003 - 2004 Analyses for phosphoproteins in activated T lymphocytes using Maldi-MS/MS method.
2000 - 2004 Identification of tumor-specific antigens recognized by human T cells
2002 - 2003 Antigen-specific immune-regulation by genetically modified ES cell-derived dendritic cells
2002 - 2003 Investigation on the molecular mechanisms of antigen presentation and recognition.
1999 - 2001 Analysis of TCR/HLA/ peptide interaction and investigation of etiology of autoimmune diseases
1999 - 2001 THE DIVESITY IN ANTIGEN RECOGNITION AND RESPONSE OF ANTIGEN-SPECIFIC HUMAN CD4^+ T-CELL CLONES
1999 - 1999 T細胞の活性化におけるNa^+イオンおよびNa^+イオン・チャンネルの役割
1998 - 1999 T細胞活性化に関わるインテグリンの構造解析
1998 - 1998 日本人の自己免疫疾患に特有のHLAクラスII・自己抗原ペプチド複合体の解析
1994 - 1994 癌細胞の浸潤・転移におけるインテグリンファミリーの役割
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Papers (91)：
Tingyu Gao, Atsushi Irie, Takahisa Kouwaki, Hiroyuki Oshiumi. Development of a single-chain variable antibody fragment against a conserved region of the SARS-CoV-2 spike protein. Scientific Reports. 2024. 14. 1
Miki Tsuruta, Masatoshi Hirayama, Poh Yin Yew, Sachiko Yoshimura, Hiroyuki Kishi, Hiroshi Hamana, Satoru Senju, Atsushi Irie, Junji Yatsuda, Tomomi Kamba, et al. Bladder cancer-associated antigens-derived long peptides activate both CTLs and Th1-cells expressing converged TCRs. CANCER SCIENCE. 2018. 109. 731-731
Shibuya I, IRIE A, Sogo S, Nishimura Y, Inagaki K. Endoplasmic reticulum stress of colonic epithelial cells is a pathogenesis of ulcerative colitis observed in the homozygous HLA-DR4 transgenic mice. Medical Science Digest. 2017. 43. 14. 741-745
Production and characterization of the single-chain anti-spike antibody that reacts with the spike protein of Wuhan and all variant strains of SARS-CoV-2
(The 52nd Annual Meeting of The Japanese Society for Immunology 2024)
Visible pathogenetic analysis of ulcerative colitis-like inflammatory bowel disease using ER-stress reporter gene and HLA-DR4 transgenic mice.
(The 51st Annual Meeting of the Japanese Society for Immunology 2022)
Production and characterization of anti-SARS-CoV-2 antibody by immunizing spike-derived peptide with high affinity to HLA-DR4
(2021)
Production and characterization of anti-SARS-CoV-2 antibody by immunizing Spike-derived peptide with high affinity to HLA-DR4
(2021)
Effective combination immunotherapy for chemoresistant mouse bladder cancer using peptide vaccines and PD-1 blockade
(The 48th Annual Meeting of The Japanese Society for Immunology 2019)
