Rchr
J-GLOBAL ID:200901091120302497
Update date: Nov. 20, 2024
Kuroda Masahiko
クロダ マサヒコ | Kuroda Masahiko
Affiliation and department:
Job title:
Professor & Chairman
Homepage URL (1):
http://www.tokyo-med.ac.jp/molpathol/
Research field (2):
Experimental pathology
, Human pathology
Research keywords (6):
Liquid biopsy
, non-coding RNA, miRNA
, extracellular vesicles(EVs)
, 核酸医薬
, 人体病理学
, Human Pathology
Research theme for competitive and other funds (49):
- 2023 - 2026 播種性休眠細胞を標的とする乳酸菌由来人工小胞を用いたがんの再発、転移の予防と治療
- 2021 - 2024 RNA activationにおける分子機構の解析
- 2021 - 2024 Analysis of the mechanism of ncRNA-mediated carcinogenesis using the DICER1 syndrome model
- 2020 - 2023 がん幹細胞を標的とする細菌由来の人工小胞を用いたがんの再発、転移治療法の開発
- 2020 - 2023 Does smooth muscle maturation, an indicator of plaque stabilization, also appear in the intima after drug-eluting stent placement?
- 2018 - 2021 Exploration and functional analysis of novel RNA-interfering nucleic acids.
- 2018 - 2021 Breast cancer patients NAC response prediction with artificial inttelligenece
- 2017 - 2020 Development of cancer stem cell specific miRNA delivery system for recurrence and metastasis from cancer.
- 2017 - 2020 Identification of novel non-coding RNA
- 2016 - 2020 Mechanisms and predictive factors of ovarian cancer metastasis to the diaphragm
- 2016 - 2019 Development of immune therapy for non-alcoholic fatty liver disease with iNKT cells
- 2016 - 2019 Elucidation of immaturity of intimal smooth muscle cells in plaque vulnerability
- 2015 - 2018 Development of novel form of mimic microRNA for microRNA replacement therapy.
- 2015 - 2017 Development of liquid biopsy against dementia
- 2014 - 2017 Development of a miRNA delivery system using Ago2/miRNA complexes modified with cancer specific peptide.
- 2014 - 2017 Development of miRNA replacement therapy
- 2014 - 2017 Modeling fusion gene-associated bone and soft tissue sarcoma and its application to therapies
- 2012 - 2016 miRNA expression profiling of PLFs stimulated with EP4 agonist
- 2013 - 2015 Analysis of KLF5/4 complex in colon cancer development
- 2013 - 2015 Inhibition of microRNA functions by novel nucleic acids, iMIR
- 2012 - 2015 Detection of pancreatic cancer by serum microRNA
- 2012 - 2015 Expression analysis of hWAPL oncogene
- 2012 - 2015 Regulation mechanisms by micro-RNA in scirrhous carcinoma
- 2010 - 2015 Identification of cardiomyogenic factor in terms of cell-based therapy/regenerative medicine
- 2012 - 2014 Development of new cancer therapy using the exosomes from patients.
- 2011 - 2014 Development of novel cancer therapy using miRNA containing exosome
- 2011 - 2013 Development of a new miRNA delivery system for targeting cancer stem cells
- 2011 - 2012 Novel therapy of myxoid liposarcoma by Chromosome re-programming
- 2010 - 2012 Serum miRNA Levels in Patients with Inflammatory Bowel Disease
- 2011 - 2011 Development of novel drug delivery system for micro RNA nucleic biomedicine using exosome from human cultured cells
- 2009 - 2011 Personalized medicine using newly identified paclitaxel-sensitive genes in gynecologic cancer
- 2009 - 2010 機能性マイクロRNAを用いた癌診断法の開発
- 2009 - 2010 血清miRNAによる超早期癌診断法の開発
- 2008 - 2010 Development of novel diagnosis and therapy against human oncogene hWAPL
- 2007 - 2009 慢性骨髄性白血病におけるDNA修復エラーの分子病態と微少残存病変の制御の研究
- 2006 - 2009 Identification of human cardiomyogenic factor
- 2006 - 2007 Development of novel therapy against human liposarcoma using siRNAlibrary
- 2003 - 2005 Development of molecular target therapy against chimeric oncogene using siRNA
- 1999 - 2004 環境ホルモンが減数分裂に影響を与える可能性
- 2001 - 2003 The basic pathological research for the establishment of the diagnoses of bone tumors and soft tissue tumors using DNA microarray.
- 2003 - 染色体テリトリーと発がん
- 2001 - 2002 TLS-/-マウスを用いたTLS標的遺伝子の単離
- 2001 - 2001 キメラ遺伝子の発がん機構
- 2000 - 2000 キメラ遺伝子の発がん機構
- 1999 - 2000 TLS-CHOP遺伝子の新規標的遺伝子DOL54を用いた脂肪肉腫の診断法の開発
- 1995 - 粘液型脂肪肉腫におけるTLS-CHOP遺伝子の解析
- 1993 - 1994 Histopathological grading, ATPase, cytogenetics and tumor associated genes of human bone and soft tissue tumors.
- Effects of endocrine disrupters on meiosis and homologous recombination process
- Analysis of TCS-CHOP gene of the myxoid liposarcoma
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Papers (264):
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Masaki Asakage, Yoshihiko Usui, Hiroyuki Komatsu, Kazuichi Maruyama, Naoya Nezu, Hiroyuki Shimizu, Kinya Tsubota, Naoyuki Yamakawa, Tomohiro Umezu, Masakatsu Takanashi, et al. Comprehensive microRNA analyses using vitreous humor of ocular sarcoidosis. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2024
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Jeong-Hwan Yoon, Eunjin Bae, Yasuo Nagafuchi, Katsuko Sudo, Jin Soo Han, Seok Hee Park, Susumu Nakae, Tadashi Yamashita, Ji Hyeon Ju, Isao Matsumoto, et al. Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation. Life science alliance. 2024. 7. 9
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Tomohiro Umezu, Tomoya Mori, Hidenori Toyoda, Kohsuke Kanekura, Akihiro Tamori, Takahiro Ochiya, Masahiko Kuroda, Tatsuya Akutsu, Yoshiki Murakami. Analysis of Carcinogenic Involvement of MicroRNA Pattern in Peripheral Non-Cancerous Tissues and Chronic Viral Liver Injury. International journal of molecular sciences. 2024. 25. 14
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Yujin Kudo, Akira Saito, Tomoaki Horiuchi, Kotaro Murakami, Masaharu Kobayashi, Jun Matsubayashi, Toshitaka Nagao, Tatsuo Ohira, Masahiko Kuroda, Norihiko Ikeda. Preoperative evaluation of visceral pleural invasion in peripheral lung cancer utilizing deep learning technology. Surgery Today. 2024
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梅津 知宏, 工藤 勇人, 嶋田 善久, 大平 達夫, 村上 善基, 池田 徳彦, 黒田 雅彦. 肺癌患者由来cfDNAから検出されたde novo mutational signatureの同定と生物学的意義の解明(Identification and biological significance of de novo mutational signatures in cfDNA derived from lung cancer patients). 日本癌学会総会記事. 2023. 82回. 213-213
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MISC (103):
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桐林和代, 稲垣夏子, 梅津知宏, 黒田雅彦. Intracellular dynamics of Gb3 and ER stress in Fabry disease. 日本遺伝カウンセリング学会誌. 2023. 44. 2
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Yasuto Takeuchi, Natsuko Kimura, Takahiko Murayama, Yukino Machida, Daisuke Iejima, Tatsunori Nishimura, Yuming Wang, Mizuki Yamamoto, Naoki Itano, Junichiro Inoue, et al. FRS2b fashions a cytokine-rich inflammatory microenvironment that promotes breast cancer carcinogenesis. CANCER SCIENCE. 2022. 113. 994-994
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桐林和代, 藤田浩司, 梅津知宏, 稲垣夏子, 黒田雅彦. Distinction of urinary sediment in Fabry disease. 日本遺伝カウンセリング学会誌. 2022. 43. 2
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桐林和代, 藤田浩司, 梅津知宏, 稲垣夏子, 黒田雅彦. ファブリー病患者の尿検体を用いた偏光顕微鏡下によるマルベリー小体検出の有用性について. 日本遺伝子診療学会大会プログラム・抄録集. 2022. 29th
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桐林和代, 原田裕一郎, 梅津知宏, 稲垣夏子, 黒田雅彦. ファブリー病におけるマルベリー細胞の立体構造についての検討. 日本人類遺伝学会大会プログラム・抄録集. 2022. 67th (CD-ROM)
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Patents (1):
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ヒトbcl10に対するモノクローナル抗体の作製法及びその抗体を用いた臨床的検査法
Books (2):
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The TLS-CHOP oncogene and human liposarcoma.
Translocations in Solid Tumors (ed. Cooper C) (Landes Bioscience) 1998
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The TLS-CHOP oncogene and human liposarcoma. in Translocations in Solid Tumors(ed. Cooper C. )
Landes Bioscience, Gerogetown, TX 1998
Education (4):
- - 1993 The University of Tokyo
- - 1993 The University of Tokyo Graduate School, Division of Medicine
- - 1989 Tokyo Medical University
- - 1989 Tokyo Medical University Faculty of Medicine
Professional career (2):
- (BLANK) (The University of Tokyo)
- (BLANK)
Work history (5):
- 1996 - 1999 ニューヨーク大学、スカーボール研究所、客員助教授
- 1996 - 1999 New York University, Skirball Institute,
- 1993 - 1998 The University of Tokyo
- 1993 - 1998 University of Tokyo, Research Assistant
- Visting Associate Professor
Committee career (8):
Awards (3):
- 2005 - 佐々記念賞
- 2001 - 東京医科大学医学会奨励賞
- 2000/12 - 日本病理学会 学術研究賞(A演説) 粘液型脂肪肉腫の腫瘍発生
Association Membership(s) (7):
American Society for Investigative Pathology
, American Association for Cancer Research
, 環境ホルモン学会
, 日本臨床細胞診学会
, 日本癌学会
, 日本病理学会
, American Association for Cancer Research
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