Rchr
J-GLOBAL ID：200901092151842267
Update date: Feb. 01, 2024
Matsui Yasuhisa
マツイ ヤスヒサ | Matsui Yasuhisa
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www2.idac.tohoku.ac.jp/dep/crcbr/
Research field (2)：
Molecular biology
, Developmental biology
Research keywords (6)：
germ cell
, epigenetics
, metabolism
, transgenerational inheritance
, pluripotent stem cell
, meiosis
Research theme for competitive and other funds (42)：
- 2019 - 2022 胎仔生殖細胞に特有の代謝状態による卵母細胞への分化制御機構
- 2012 - 2018 エピゲノム研究に基づく診断・治療へ向けた新技術の創出
- 2015 - 2018 International joint research on gamete formation through the cutting-edge analysis system
- 2013 - 2018 Mechanisms regulating gamete formation in animals
- 2013 - 2018 Molecular networks regulating mouse primordial germ cell development
- 2013 - 2016 Molecular mechanisms regulating conversion of pluripotential stem cells into Germ cells
- 2008 - 2012 Gene networks regulating development of primordial germ cells
- 2007 - 2012 The Germline: Its Developmental Cycle and Epigenome Network
- 2005 - 2009 Integrated cancer research using in vivo models
- 2005 - 2009 がん研究の資材有効保存と利用に関する研究
- 2003 - 2008 生殖細胞の発生プロセス・再プログラム化とエピジェネティクス
- 2003 - 2007 マウス始原生殖細胞形成を制御する分子カスケードの解明
- 2004 - 2006 Identification of genes involved E-cadherin-dependent germ cell specification
- 2003 - 2004 始原生殖細胞の分化可塑性を制御する核内基盤の解析
- 2001 - 2002 Mechanisms of differentiation of primordial germ cells.
- 1999 - 2002 Molecular genetic analysis on the regulatory mechanism for germ-soma differentiation in mammals
- 2000 - 2000 マウス生殖細胞系譜決定の分子機構
- 1999 - 2000 In vitro reconstruction of tissue function with the immortalized cell lines from transgenic mouse
- 1998 - 2000 Identification of genes specifically expressed in developing fetal mouse germ cells
- 1998 - 2000 Establishment of functional germ cell precursor cell lines
- 1999 - 1999 ダイオキシン類化合物の生体毒性機構に関する研究
- 1999 - 1999 Bcl-2ファミリー分子による生殖細胞の腫瘍化および増殖・分化の制御
- 1998 - 1998 マウス生殖細胞系譜決定の分子機構
- 1995 - 1998 Molecular Mechanisms of Germ Cell Formation
- 1997 - 1997 マウス生殖細胞系譜決定の分子機構
- 1993 - 1997 発生・形態形成の個体レベルにおける分子生物学的研究
- 1993 - 1997 発生・形態形成の個体レベルにおける分子生物学的研究
- 1993 - 1997 発生・形態形成の個体レベルにおける分子生物学的研究
- 1993 - 1997 発生・形態形式の個体レベルにおける分子生物学的研究
- 1995 - 1996 Study of the effect of dioxin on the next generations using embryonic germ cells.
- 1994 - 1996 Immortalization of multipotent stem cells by using the oncogene transgenic mice
- 1994 - 1996 Cooperation and information exchange with European countries.
- 1993 - 1996 ES細胞を用いた未知遺伝子の検索
- 1995 - 1995 c-kitがん原遺伝子の発現と機能
- 1994 - 1994 テラトーマ発症におけるc-Kitとそのリガンド及び新規キナーゼタンパク質の関与
- 1994 - 1994 c-kitがん原遺伝子の発現と機能
- 1994 - 1994 始原生殖細胞由来の胚幹細胞株の発生工学への応用
- 1993 - 1994 Derivation of primordial germ cell lines and their application to transgenic technology
- 1993 - 1993 始原生殖細胞由来の胚幹細胞株の発生工学への応用
- 1993 - 1993 始原生殖細胞の増殖におけるチロシンキナーゼ型レセプターの役割
- 1993 - 1993 c-kitがん原遺伝子の発現と機能
- 1992 - 1992 温度感受性増殖制御下細胞の増殖回復を促す遺伝子の探索
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Papers (118)：
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Yohei Hayashi, Yukiko Tando, Yumi Ito-Matsuoka, Kaho Ikuta, Asuka Takehara, Katsutaro Morino, Hiroshi Maegawa, Yasuhisa Matsui. Nutritional and metabolic control of germ cell fate through O-GlcNAc regulation. EMBO Reports. 2023
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Yukiko Tando, Yasuhisa Matsui. Identification of spermatogenesis-associated changes in DNA methylation induced by maternal exposure to chemicals in male germ cells. STAR Protocols. 2022. 3. 4. 101912-101912
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Yohei Hayashi, Yasuhisa Matsui. Metabolic Control of Germline Formation and Differentiation in Mammals. Sexual Development. 2022. 1-16
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Yasuhisa MATSUI, Yohei HAYASHI. Metabolic pathways regulating the development and non-genomic heritable traits of germ cells. Journal of Reproduction and Development. 2022. 68. 2. 96-103
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Yukiko Tando, Hitoshi Hiura, Asuka Takehara, Yumi Ito-Matsuoka, Takahiro Arima, Yasuhisa Matsui. Epi-mutations for spermatogenic defects by maternal exposure to Di (2-ethylhexyl) phthalate. eLife. 2021. 10. e70322
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MISC (52)：
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松居 靖久, 丹藤 由希子, 吉崎 嘉一, 有馬 隆博, 河野 友宏, 大隅 典子. 胎児期環境・小児期が与える将来の老化 親の環境要因が仔の脳と精子形成に影響するしくみ. 日本老年医学会雑誌. 2022. 59. Suppl. 47-47
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鴻原葵, 松居靖久, 岡村大治. マウス始原生殖細胞が生み出す多様な多能性スペクトル. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
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Hayashi Y, Otsuka K, Ebina M, Igarashi K, Takehara A, Matsumoto M, Kanai A, Igarashi K, Soga T, Matsui Y. Correction: Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells (Proceedings of the National Academy of Sciences of the United States of America (2017) 114 (8289-8294) DOI: 10.1073/pna. Proceedings of the National Academy of Sciences of the United States of America. 2018. 115. 30
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Nana Aoki, Kentaro Mochizuki, Yasuhisa Matsui. Fthl17 gene expression is regulated by DNA methylation state of its 5 '-upstream region in cancer cells and germline stem cells. MECHANISMS OF DEVELOPMENT. 2017. 145. S134-S134
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渡邊 利雄, 小河 穂波, 田沼 延公, 早川 夏姫, 住吉 麻実, 岸本 綾子, 松居 靖久, 鈴木 麻衣, 佐々木 希, 大内 司, et al. ホスファターゼ研究のカティングエッジ メディカルイノベーションへの橋渡しを目指して 脱リン酸化酵素PP6の触媒サブユニットのPpp6cは着床後の胚の正常な発生に不可欠である. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [4W6-p
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Books (3)：
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卵子学
京都大学学術出版会 2011
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加齢医学 エイジング・ファイン
東北大学出版会 2007
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キーワードでわかる発生再生イラストマップ
羊土社 2005
Lectures and oral presentations (41)：
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Epigenetic control of germ cell development.
(International Symposium on EPIGENOME 2019 2019)
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Similarity and differences of germness and pluripotency.
(The International Research Symposium on Germness and pluripotency of the planarian in comparison eith the Fly and Mouse Systems 2018)
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Epigenetic and metabolic controls of germ cell development
(The International Research Symposium on Regulation of Germ Cell Development in vivo and in vitro. 2017)
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Molecular bases of germ cell propoeties ensuring continuity of lives.
(Tohoku Forum for Creativity, Thematic Program 2017, Aging Science: from Molecules to Society 2017)
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De-repression of germ cell-specific genes in pluripotential stem cells and in somatic cells.
(International Symposium on Epigenome Dynamics and Regulation in Germ Cells. 2016)
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Education (2)：
- - 1988 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences 生命薬学専攻
- - 1983 The University of Tokyo Faculty of Pharmaceutical Science 薬学科
Professional career (1)：
- 薬学博士 (The University of Tokyo)
Work history (6)：
Committee career (2)：
- 2014/04 - 現在 大学連携バックアッププロジェクト(IBBP)推進委員会 副委員長
- 2009/05 - 2020/03 日本発生生物学会 副編集長
Association Membership(s) (2)：
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