Rchr
J-GLOBAL ID：200901092432533433
Update date: Feb. 16, 2024
Kudo Yasusei
クドウ ヤスセイ | Kudo Yasusei
Affiliation and department：
Homepage URL (1)：
https://yasusei6.wixsite.com/yasuseikudo
Research field (2)：
Surgical dentistry
, Oral medicine (pathology)
Research theme for competitive and other funds (47)：
- 2023 - 2026 歯周病が惹起する全身炎症性疾患の機序解明と酸化ストレス制御による予防法確立
- 2022 - 2026 Investigation of novel oral cancer-specific molecular targets based on genetic diversity
- 2022 - 2025 Investigation of the pathophysiology of oral cancer caused by Fusobacterium nucleatum infection
- 2022 - 2025 The identification of genes involved in the maintenance and regeneration of salivary gland stem / progenitor cells and application to new xerostomia treatment
- 2022 - 2025 口腔がんにおける免疫環境構築機構の解明
- 2021 - 2025 Investigation of novel molecular targets for oral cancer stem cells and establishment of novel oral cancer treatment strategy
- 2019 - 2024 Analysis of Pathogenesis of Autoimmunity through Communication between Organs
- 2020 - 2023 歯周炎惹起酸化ストレスに鉄代謝が及ぼす影響と体血管反応性改善のための臨床的戦略
- 2019 - 2022 Establishment of novel oral cancer stem cell model mimicking human oral cancer by reprogramming and insertion of gene mutation
- 2019 - 2021 Clarification of the mechanism on differentiation of pluripotent stem cells by Aurora-B and its application to regeneration therapy
- 2018 - 2021 Elucidation of regulatory chemical messengers in oral cancer stem cell niche and its diagnostic and therapeutic application
- 2018 - 2020 Molecular Mechanism of Autoimmune Germinal Center Reaction and a New Therapeutic Strategy for Autoimmunity
- 2017 - 2020 The development of preventives and therapeutics against systemic endothelial dysfunction induced by the periodontal inflammation and the effects of anesthetics to the induced endothelial dysfunction
- 2017 - 2019 Study on the generation of oral cancer stem cell and analysis of its nature
- 2017 - 2019 Establishment of highly metastatic mice model of oral squamous cell carcinoma
- 2016 - 2019 Analysis of autoimmunity caused by environmental factors~New pathogenesis of autoimmune disease~
- 2016 - 2019 Clarification of the mechanism of oral carcinogenesis by the defect of degradation of chromosome passenger complex protein
- 2016 - 2019 Elucidation of novel mechanism to lead DNA over-replication
- 2015 - 2017 Explore for master regulator of EMT in oral cancer
- 2013 - 2015 The mechanism of tumorigenesis by disruption of the regulation of geminin proteolysis
- 2011 - 2014 Mechanism of carcinogenesis by dysregulation of cell cycle via abnormal ubiquitin-mediated proteolysis
- 2011 - 2012 The involvement and their molecular mechanism of microRNAs in the invasion of oral cancer
- 2009 - 2012 Elucidation of invasive andmetastatic mechanism in oral cancer for application to molecular based diagnosisand gene therapy
- 2008 - 2010 Study for degradation mechanism of a cell cycle regulator induced by Stress-activated MAP kinases
- 2008 - 2010 Histological and molecular biological study for standardization of pathological diagnosis of salivary gland tumors
- 2008 - 2010 Oncogenic role of APC/C ubiquitin ligase inhibitor, Emi1
- 2007 - 2008 口腔扁平上皮癌の浸潤に関わる新規因子の機能および診断への応用の可能性
- 2005 - 2007 Development of a novel therapeutic agent of bone using synthetic peptide of ameloblastin
- 2005 - 2006 口腔癌におけるSkp2およびCks1タンパクの過剰発現のメカニズムの解明
- 2005 - 2006 PC-1を標的としたセメント質形成機構の解明と歯周再生療法開発に関する萌芽研究
- 2004 - 2005 Periodontal destruction and innate immunity via toll-like receptors
- 2003 - 2005 Study on alteration of expression of genes and proteins related to development, progression and characteristic morphogenesis of salivary gland tumors
- 2003 - 2004 SKP2siRNAを用いたp27タンパク分解抑制による制癌効果
- 2003 - 2004 多形性腺腫細胞株の樹立と同細胞株を用いた上皮間葉形質転換に関する検討
- 2002 - 2004 Identification creation of bioactive sites of enamel proteins for developing a new therapy of periodontal tissue regeneration.
- 2000 - 2001 口腔扁平上皮癌細胞における癌抑制遺伝子P27^<kip1>遺伝子導入による制癌効果
- 2000 - 2001 Experimental pathological study on roles of chemokines in LPS-induced periodontal tissue destruction - Basic analysis on remedical effects of specific antibody against chemokine -
- 1999 - 2001 Establishment of cementblast cell lines and periodontal ligament cell lines
- 1998 - 2000 Development of dental implant with support of periodontal ligament
- 1998 - 1999 Experimental pathological study on roles of LPS-binding receptor CD14 in LPS-induced periodontal tissue destruction
- 1998 - 1999 Analysis of Cell Cycle Regulators and Extracellular Matrices Associated with Cell Proliferation in Salivary Gland Tumors
- 1999 - 口腔扁平上皮癌における細胞周期調節因子の異常に関する研究
- 1999 - Study on the abnormality of cell cycle regulator in oral squamous cell carcinoma
- ユビキチンリガーゼSCF複合体によるタンパク分解機構の解明
- 口腔扁平上皮癌の浸潤・転移に関わる新規因子の同定
- The mechanism of proteolysis mediated by ubiquitin ligase SCF complex
- Exploring novel factor for invasion and metastasis of oral squamous cell carcinoma
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Papers (140)：
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Shengjian Jin, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Hiroko Hagita, Motoharu Sarubo, Natsumi Fujiwara, Guangying Qi, et al. Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma. Cancer medicine. 2023
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Wenhua Shao, Mayuko Ichimura-Shimizu, Hirohisa Ogawa, Shengjian Jin, Mitsuko Sutoh, Satoko Nakamura, Miki Onodera, Hirosuke Tawara, Shunji Toyohara, Ryoji Hokao, et al. Establishment of repeated liver biopsy technique in experimental mice. Heliyon. 2023. 9. 6. e16978
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Anrizandy Narwidina, Aya Miyazaki, Kokoro Iwata, Rika Kurogoushi, Asuna Sugimoto, Yasusei Kudo, Keita Kawarabayashi, Yoshihito Yamakawa, Yuki Akazawa, Takamasa Kitamura, et al. Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression. Biochemical and biophysical research communications. 2023. 650. 47-54
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吉田 佳世, 吉田 賀弥, 瀬山 真莉子, 芽形 真奈, 藤原 奈津美, 水澤 典子, 毛利 安宏, 工藤 保誠, 尾崎 和美. 歯周病原菌由来細胞外小胞を介した肺炎発症メカニズムの解明. 日本歯周病学会会誌. 2023. 65. 春季特別. 137-137
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Shao Wenhua, Takaaki Tsunematsu, Masaaki Umeda, Hiroaki Tawara, Natsumi Fujiwara, Yasuhiro Mouri, Rieko Arakaki, Naozumi Ishimaru, Yasusei Kudo. Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma. Cancer medicine. 2023. 12. 7. 8510-8525
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MISC (220)：
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牛尾 綾, 新垣 理恵子, 工藤 保誠, 石丸 直澄. 次世代歯学研究者のゆくえ 自己免疫疾患モデルにおける標的臓器常在型マクロファージの役割. Journal of Oral Biosciences Supplement. 2019. 2019. 61-61
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牛尾 綾, 大塚 邦紘, 新垣 理恵子, 工藤 保誠, 石丸 直澄. CCL22 and autoimmune diseases. 臨床免疫・アレルギー科 = Clinical immunology & allergology. 2019. 71. 5. 520-526
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牛尾 綾, 新垣 理恵子, 大塚 邦紘, 工藤 保誠, 石丸 直澄. シェーグレン症候群病態形成におけるCCL22産生マクロファージの役割. 日本病理学会会誌. 2019. 108. 1. 317-317
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大塚 邦紘, 山田 安希子, 齋藤 雅子, 牛尾 綾, 常松 貴明, 木曽田 暁, 工藤 保誠, 新垣 理恵子, 石丸 直澄. Ascl2を介した濾胞ヘルパーT細胞分化異常による自己免疫疾患の病態形成を促進する. 日本病理学会会誌. 2019. 108. 1. 317-317
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新垣 理恵子, 牛尾 綾, 大塚 邦紘, 工藤 保誠, 石丸 直澄. 多層化カーボンナノチューブ吸入暴露初期の肺胞マクロファージの動態. 日本病理学会会誌. 2019. 108. 1. 353-353
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Education (2)：
- 1996 - 1999 Hiroshima University Graduate School, Division of Dental Research
- 1990 - 1996 Hiroshima University Faculty of Dentistry
Professional career (1)：
Work history (8)：
- 2020/07 - 現在 Tokushima University Graduate School of Biomedicak Sciences Department of Oral Bioscience Professor
- 2012/04 - 2020/06 Tokushima University Graduate School of Biomedical Sciences Department of Oral Molecular Pathology
- 2002/04 - 2013/10 広島大学大学院医歯薬学総合研究科 助教
- 2003/11 - 2012/03 Hiroshima University
- 2011/01 - 2011/03 ニューヨーク大学医学部・がん研究所 客員研究員
- 2001 - 2003 ニューヨーク大学医学部
- 2001 - 2003 New York University School of Medicine
- 1999 - 2002 Hiroshima University Faculty of Dentistry
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Awards (9)：
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