Lee Seon Hwa

リソンファ | Lee Seon Hwa

Affiliation and department：
Homepage URL (1)： http://www.pharm.tohoku.ac.jp/~bunseki/bunseki.html

Research field (2)： Pharmaceuticals - analytical and physicochemistry , Clinical pharmacy

Research keywords (6)： Oxidative stress , Lipid peroxidation , Chemical modification , Mass spectrometry , Proteomics , Lipidomics

Research theme for competitive and other funds (12)：

2022 - 2025 インスリン分解酵素の活性分離に及ぼすチロシン修飾の影響
2021 - 2023 表皮ケラチンを用いた非侵襲的環境エクスポゾーム解析法の構築
2019 - 2022 Pyridoxamine could be a candidate drug for Parkinson`s disease: Mechanistic study to reduce dopamine-induced toxicity
2016 - 2019 Glycation and oxidation on amyloid beta: Molecular mechanisms of the effects on aggregation and protease-resistance
2016 - 2019 内因性ピリドキサミン-アルデヒド付加体の探索:酸化ストレスマーカーとしての評価

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Papers (96)：

Seon Hwa Lee, Kazuyuki Takahashi, Yusuke Hatakawa, Tomoyuki Oe. Lipid peroxidation-derived modification and its effect on the activity of glutathione peroxidase 1. Free Radical Biology and Medicine. 2023. 208. 252-259
Sawaka Ono, Yusuke Hatakawa, Seon Hwa Lee, Tomoyuki Oe. Stable Isotope Dilution LC/ESI-SRM/MS Analysis for Highly Polar Bioactive Dipeptides Found in Fermented Brown Rice Product using a Porous Graphitic Carbon Column. Food Analytical Methods. 2023
Seon Hwa Lee, Mizuki Tsutsui, Atsushi Matsunaga, Tomoyuki Oe. Lipid hydroperoxide-derived insulin resistance and its inhibition by pyridoxamine in skeletal muscle cells. Toxicological Research. 2022
Dai Kato, Yoshiaki Takahashi, Haruto Iwata, Yusuke Hatakawa, Seon Hwa Lee, Tomoyuki Oe. Comparative studies for amyloid beta degradation: “Neprilysin vs insulysin”, “monomeric vs aggregate”, and “whole Aβ40 vs its peptide fragments”. Biochemistry and Biophysics Reports. 2022. 30. 101268-101268
Go Usuzawa, Seon Hwa Lee, Tomoyuki Oe. Alternative LC/ESI-MS/MS approach to screen hemoglobin N-terminal modifications. International Journal of Mass Spectrometry. 2021. 468. 116651-116651

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MISC (96)：

李宣和, 高橋亮, 大江知行. マススペクトロメトリーを駆使した生体分子解析によるバイオメディカル研究の新展開脂質ペルオキシドを介したタンパク質の修飾の細胞培養系における脂肪酸の安定同位体標識(SILFAC)と同位体パターン依存的なスキャンを組み合わせたスクリーニング法(Frontier of biomedical science by biomolecule analysis based on mass spectrometry Screening of lipid hydroperoxide-mediated protein mo. 日本薬学会年会要旨集. 2017. 137年会. 1. 258-258
藤岡修平, 高橋亮, 大江知行, 李宣和. ヒト内皮細胞中のアンジオテンシンII誘発脂質過酸化のLC/ESI-MS解析. 日本薬学会年会要旨集. 2017. 137年会. 2. 246-246
川瀬士瑛, 廣嶋佑亮, 大江知行, 李宣和. On-tape消化法を用いるヒト表皮ケラチン上の化学修飾スクリーニング. 日本薬学会年会要旨集. 2017. 137年会. 2. 286-286
池田真人, 横田涼, 大江知行, 李宣和. N末端ピルビン酸アミド型アンジオテンシンの同位体希釈LC/ESI-SRM/MS分析. 日本薬学会年会要旨集. 2017. 137年会. 2. 286-286
保坂周斗, 本多拓人, 李宣和, 大江知行. 生体模倣トラッピングカクテル:新規反応性代謝物評価法の開発研究. 日本薬学会年会要旨集(CD-ROM). 2017. 137th. 2. ROMBUNNO.25P-am07S-246

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Books (5)：

Lipid peroxide-DNA adducts (Chanter 11) in Chemical Carcinogenesis, Current Cancer Research, pp. 227-244.
Springer Science+Business Media LLC 2011 ISBN:9781617379949
Chemistry of polycyclic aromatic hydrocarbons (PAH) o-quinones generated by the aldo-keto reductase pathway of PAH activation (Chapter 9) in Aldo-keto reductases and toxicant metabolism (ACS Symposium Series 865), pp.127-137
Oxford University Press 2004 ISBN:9780841238466
Aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons (Chapter 6) in Aldo-keto reductases and toxicant metabolism (ACS Symposium Series 865), pp. 83-99
Oxford University Press 2004 ISBN:9780841238466
Analysis of etheno 2’-deoxyguanosine adducts as dosimeters of AKR mediated-oxidative stress (Chapter 10) in Aldo-keto reductases and toxicant metabolism (ACS Symposium Series 865), pp.139-152
Oxford University Press 2004 ISBN:9780841238466
Vitamin C and Cancer in The antioxidant Vitamins C and E, pp. 50-65
AOCS Press 2002 ISBN:1893997294

Lectures and oral presentations (24)：

Alternative approach for biomarker discovery through chemical modificomics
(2nd Tohoku University-Sichuan University Pharmaceutical Sciences Collaboration Symposium 2019)
Lipid peroxidation-mediated modifications to biomolecules: mass spectrometry-based mechanistic study and selective screening
(2018)
基礎講座:生体分子の構造解析・定性の基礎
(第45回BMSコンファレンス 2018)
Screening of lipid hydroperoxide-mediated protein modification using stable isotope labeling by fatty acids in cell culture (SILFAC) coupled with isotope pattern dependent scan
(日本薬学会第137年会 2017)
Inhibition of lipid hydroperoxide-derived protein damages by pyridoxamine
(KSMS Summer Conference 2016)

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Education (3)：

1994 - 1999 Sungshin Women's University Department of Chemistry Ph. D.
1990 - 1992 Sungshin Women's University Department of Chemistry Master of Science
1987 - 1990 Sungshin Women's University, Seoul, Korea College of Natural Science Department of Chemistry

Professional career (1)：

Work history (8)：

2020/05 - 現在 Tohoku University Graduate School of Pharmaceutical Sciences Associate Professor
2008/05 - 2020/04 Tohoku University Graduate School of Pharmaceutical Sciences Assistant Professor
2007/11 - 2008/04 Tohoku University, Sendai, Japan Graduate School of Pharmaceutical Sciences Visiting Scholar
2005/10 - 2007/08 University of Pennsylvania School of Medicine Center of Excellence in Environmental Toxicology Director of biomarker facility core
2004/07 - 2007/08 University of Pennsylvania School of Medicine Department of Pharmacology Research assistant professor

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Committee career (2)：

2020/02 - 2021/09 PPF2020/2021 Member of executive committee
2017/09 - 2018/07 The 45th Biological Mass Spectrometry Conference Member of executive committee

Awards (4)：

2012/12/01 - Tohoku Branch of The Pharmaceutical Society of Japan Award for Young Scientists from Tohoku Branch of The Pharmaceutical Society of Japan
2011/08 - Journal of Chromatography B Top Cited Reviews 2008 to 2009 in Journal of Chromatography B
2005/06 - Rapid Communication in Mass Spectrometry RCM Beynon Prize Award Best paper published in the journal Rapid Communication in Mass Spectrometry in 2003 - 2004
2004/03 - American Association for Cancer Research (AACR) AFLAC Scholar-in-Training Award

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