Rchr
J-GLOBAL ID:200901092598955514   Update date: Jan. 27, 2026

Kazama Hiromi

Kazama Hiromi
Research field  (1): Medical biochemistry
Research keywords  (3): ERストレス ,  分子細胞生物学 ,  乳癌細胞
Research theme for competitive and other funds  (4):
  • 2024 - 2027 転移・難治性乳癌に対する「小胞体内プロテオスタシス」を標的とする新規治療法
  • 2020 - 2023 Targetting aggresome formation in metastatic breast cancer cells
  • 2016 - 2019 Novel therapeutic strategy in metastatic breast cancer by targeting misfolded protein-transport along microtubules and aggresome formation
  • 2005 - 2006 ヒト味覚受容体遺伝子発現を利用した新規な味覚検査法の開発
Papers (35):
  • 森谷 昇太, 風間 宏美, 高野 直治, 宮澤 啓介, 岡部 聖一. ビタミンK2はROS-NOXA-MCL1経路を標的とすることにより急性骨髄性白血病におけるベネトクラクスの殺細胞作用を増強する. 東京医科大学雑誌. 2024. 82. 2. 234-234
  • Tetsuzo Tauchi, Shota Moriya, Seiichi Okabe, Hiromi Kazama, Keisuke Miyazawa, Naoharu Takano. Vitamin K2 sensitizes the efficacy of venetoclax in acute myeloid leukemia by targeting the NOXA-MCL-1 pathway. PloS one. 2024. 19. 7. e0307662
  • Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa. Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression. PloS one. 2023. 18. 12. e0295273
  • Gai Yamashita, Naoharu Takano, Hiromi Kazama, Kiyoaki Tsukahara, Keisuke Miyazawa. p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs. Cell Death Discovery. 2022. 8. 1. 502-502
  • Tomonori Hirose, Yoshinobu Sugitani, Hidetake Kurihara, Hiromi Kazama, Chiho Kusaka, Tetsuo Noda, Hidehisa Takahashi, Shigeo Ohno. PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling. Development (Cambridge, England). 2022. 149. 21
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MISC (149):
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Patents (1):
  • 新規な味覚物質受容体
Books (1):
  • 信号機本
    交通工学研究会 2026 ISBN:4905990998
Education (2):
  • 2002 - 2004 Nihon University
  • 1996 - 2000 Nihon University College of Bioresource Sciences
Professional career (1):
  • 修士(生物資源科学) (日本大学)
Awards (1):
  • 2019/06 - 東京医科大学 佐々記念賞
Association Membership(s) (2):
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE CANCER ASSOCIATION
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