J-GLOBAL ID:200901092598955514   Update date: Sep. 17, 2020

Kazama Hiromi

Kazama Hiromi
Research field  (1): Medical biochemistry
Research keywords  (3): 乳癌細胞 ,  分子細胞生物学 ,  Physiology of development(=generation) and growth Cell physiology
Research theme for competitive and other funds  (4):
  • 2020 - 2023 Targetting aggresome formation in metastatic breast cancer cells
  • 2016 - 2019 Novel therapeutic strategy in metastatic breast cancer by targeting misfolded protein-transport along microtubules and aggresome formation
  • 2016 - 2019 不良タンパク質の微小管輸送およびアグリソーム形成を標的とする転移性乳癌の新規治療
  • 2005 - 2006 ヒト味覚受容体遺伝子発現を利用した新規な味覚検査法の開発
Papers (24):
  • Ayuka Yokota, Masaki Hiramoto, Hirotsugu Hino, Mayumi Tokuhisa, Masaya Miyazaki, Hiromi Kazama, Naoharu Takano, Keisuke Miyazawa. Sequestosome 1 (p62) accumulation in breast cancer cells suppresses progesterone receptor expression via argonaute 2. Biochemical and biophysical research communications. 2020. 531. 2. 256-263
  • Hideki Tanaka, Hirotsugu Hino, Shota Moriya, Hiromi Kazama, Masaya Miyazaki, Naoharu Takano, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa. Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin. Biochemistry and biophysics reports. 2020. 22. 100750-100750
  • Hirotsugu Hino, Noriyoshi Iriyama, Hiroko Kokuba, Hiromi Kazama, Shota Moriya, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa. Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes. Cancer science. 2020. 111. 6. 2132-2145
  • Kohki Ota, Takashi Okuma, Alberto De Lorenzo, Ayuka Yokota, Hirotsugu Hino, Hiromi Kazama, Shota Moriya, Naoharu Takano, Masaki Hiramoto, Keisuke Miyazawa. Fingolimod sensitizes EGFR wild-type non-small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest. Oncology reports. 2019. 42. 1. 231-242
  • Hiromi Kazama, Masaki Hiramoto, Kana Miyahara, Naoharu Takano, Keisuke Miyazawa. Designing an effective drug combination for ER stress loading in cancer therapy using a real-time monitoring system. Biochemical and biophysical research communications. 2018. 501. 1. 286-292
MISC (100):
  • 森谷 昇太, 風間 宏美, 高野 直治, 平本 正樹, 宮澤 啓介. Combined treatment with bortezomib plus clarithromycin overcomes stromal cell-mediated drug resistance in myeloma cells via ER-stress and NOXA induction(和訳中). 東京医科大学雑誌. 2020. 78. 1. 74-74
  • 高野 直治, 山田 裕美子, 風間 宏美, 徳久 真弓, 日野 浩嗣, 平本 正樹, 宮澤 啓介, 宮原 か奈, 石川 孝, 藤田 浩司, et al. 乳がん細胞におけるミトコンドリアダメージにより誘導されるBRCA1の新規分解機構の解析. 東京医科大学雑誌. 2020. 78. 1. 75-76
  • 小川 雅人, 鈴木 菫, 宮崎 誠也, 風間 宏美, 平本 正樹, 宮澤 啓介. 抗寄生虫薬の抗がん剤としてのリポジショニングの可能性について. 東京医科大学雑誌. 2020. 78. 1. 76-77
  • 田中 英基, 日野 浩嗣, 森谷 昇太, 風間 宏美, 高野 直治, 平本 正樹, 宮澤 啓介, 塚原 清彰. Comparison of autophagy inducing effect in various tyrosine kinase inhibitors in cancer cells by quantitative autophagy flux monitoring system(和訳中). 東京医科大学雑誌. 2019. 77. 4. 323-323
  • 平本 正樹, 高野 直治, 風間 宏美, 日野 浩嗣, 宮澤 啓介. ゲフィチニブの分子標的によるアクチン細胞骨格の再構成(Actin cytoskeleton reorganization mediated by a cellular target of gefitinib). 日本癌学会総会記事. 2019. 78回. P-1259
Patents (1):
  • 新規な味覚物質受容体
Education (4):
  • - 2004 Nihon University
  • - 2004 Nihon University
  • - 2000 Nihon University
  • - 2000 Nihon University
Professional career (1):
  • 修士 (日本大学)
Work history (3):
  • 2015/04 - 現在 東京医科大学
  • 2000/09 - 2005/01 Nihon University School of Medicine
  • 2000 - - Assistant
Awards (1):
  • 2019/06 - 東京医科大学 佐々記念賞
Association Membership(s) (2):
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