J-GLOBAL ID：200901092598955514
Update date: Aug. 22, 2024
Kazama Hiromi
Kazama Hiromi
Research field (1)：
Medical biochemistry
Research keywords (3)：
ERストレス
, 分子細胞生物学
, 乳癌細胞
Research theme for competitive and other funds (4)：
2024 - 2027 転移・難治性乳癌に対する「小胞体内プロテオスタシス」を標的とする新規治療法
2020 - 2023 Targetting aggresome formation in metastatic breast cancer cells
2016 - 2019 Novel therapeutic strategy in metastatic breast cancer by targeting misfolded protein-transport along microtubules and aggresome formation
2005 - 2006 ヒト味覚受容体遺伝子発現を利用した新規な味覚検査法の開発
Papers (34)：
Tetsuzo Tauchi, Shota Moriya, Seiichi Okabe, Hiromi Kazama, Keisuke Miyazawa, Naoharu Takano. Vitamin K2 sensitizes the efficacy of venetoclax in acute myeloid leukemia by targeting the NOXA-MCL-1 pathway. PloS one. 2024. 19. 7. e0307662
Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa. Clarithromycin overcomes stromal cell-mediated drug resistance against proteasome inhibitors in myeloma cells via autophagy flux blockage leading to high NOXA expression. PloS one. 2023. 18. 12. e0295273
Gai Yamashita, Naoharu Takano, Hiromi Kazama, Kiyoaki Tsukahara, Keisuke Miyazawa. p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs. Cell Death Discovery. 2022. 8. 1
Tomonori Hirose, Yoshinobu Sugitani, Hidetake Kurihara, Hiromi Kazama, Chiho Kusaka, Tetsuo Noda, Hidehisa Takahashi, Shigeo Ohno. PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling. Development (Cambridge, England). 2022
Keitaro Miyake, Naoharu Takano, Hiromi Kazama, Hiroyuki Kikuchi, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa. Ricolinostat enhances adavosertib-induced mitotic catastrophe in TP53-mutated head and neck squamous cell carcinoma cells. International journal of oncology. 2022. 60. 5
