Research field (5)：
Environmental effects of chemicals
, Environmental effects of radiation
, Metabolism and endocrinology
, Physiology
, Neuroscience - general
Research keywords (8)：
Environmental Physiology
, Neuroscience(Neuroendocrinology)
, Cerebellum
, Endocrine Disruption
, Development
, Hormone
, Environment
, Thyroid
Research theme for competitive and other funds (40)：
2024 - 2027 Mechanisms of thyroid hormone action on the development of higher brain function.
2022 - 2025 腱板断裂修復部に対する体外衝撃波の組織修復促進効果の検討
2021 - 2024 基礎・臨床科目実習を活用したチームワーク・リーダーシップ教育の開発と評価
2020 - 2023 ネグレクトの抑制における分子作用機序の解明:乳汁成分とエピゲノム修飾の解析
2018 - 2022 Epigenetic modulation by chemical substances on thyroid hormone-mediated brain development.
2017 - 2020 Analysis of the fetal/uterine environment on nurturing behavior in the next generation: understanding the causes of neglect and its recovery
2015 - 2018 The preventive effect of ursolic acid on the degeneration of rotator cuff muscle
2014 - 2017 Establishment of disease due to CIN85 abnormality: Analysis of pathology and molecular variation of hyperactivity, maternal neglect and mental retardation
2014 - 2017 The role of thyroid hormone function in different brain regions during brain development and the development of novel methods to measure the effect of environmental chemicals.
2013 - 2017 Effects of environmental factors on small lipophilic hormone-mediated development of brain function
2014 - 2016 A novel pathway of the differenciation of Beige cells - analisis of adipocyte specific EID1-overexpressed mice
2012 - 2015 compensatory hypertrophy of the infraspinatus muscle in rotator cuff tear rat model
2012 - 2014 Effect of thyroid hormone to muscle hypertrophy by aerobic training.
2011 - 2013 Effect of environmental chemicals on brain development ; examination of the various aspects in glias and neurons.
2010 - 2012 Effects of androgen receptor on aromatase expression
2010 - 2012 Effects of Environmental Chemicals on Bone Metabolism through Steroid and Xenobiotic Receptor (SXR)
2009 - 2012 Crosstalk between nuclear receptor and transcription cofactor on brain development and its modulation by environmental chemicals.
2009 - 2011 Analysis of behavior disorder and the deficient rescue of CIN85 knockout mouse that shows hyperactivity and rearing neglect to newborns
2009 - 2010 甲状腺癌発症の性差~アロマターゼ発現とエストロゲンとの関連
2008 - 2010 The effect of environmental chemicals on the interaction of thyroid hormone receptor and retinoic acid receptor-related orphan receptor (ROR).
2008 - 2009 トランスポートソームの機能破綻による神経性異常とヒトにおける病態解析
2007 - 2008 Regulation of aromatase expression by RORα in breast cancer
2006 - 2008 Analysis of behavioral quantity by the loss of function of CIN85 related to receptor endocytosis
2005 - 2008 Molecular mechanisms generating a critical period of thyroid hormone action on brain development and its modulation by environmental chemicals
2006 - 2007 EFFECTS OF ENDOCRINE DISRUPTING CHEMICALS ON THE PROGRESSION OF BREAST CANCER -ITAIMS AT THE DEVELOPMENT OF ANOVEL REMOVAL METHOD AND TREATMENT
2005 - 2006 The novel mechanism of the potentiation of estrogen action by steroid and xenobiotic receptor (SXR) in breast cancer cells.
2005 - 2006 The Roles of PCB-regulated TR-binding Proteins during brain development.
2004 - 2005 Tamoxifen activates CYP3A4 and MDR-1 genes through steroid and xenobiotic receptor in breast cancer cells.
2002 - 2004 The role of thyroid hormone action in the developing brain and the mechanism generating critical period of its action.
2002 - 2004 Role of neurotransmitters and environmental enrichment in the critical period of brain development
2002 - 2003 The effect of endocrine-disrupting chemicals on development of breast cancer.
2002 - 2002 甲状腺ホルモンによる中枢神経系発達に及ぼす内分泌撹乱物質の作用
1995 - 1995 下垂体、視床下部におけるホルモンによる転写活性変化の細胞単位での検索
1994 - 1994 下垂体、視床下部におけるホルモンによる転写活性変化の細胞単位での検索
1992 - 1994 THE GENERATION MECHANISMS OF CIRCADIAN RHYTHM IN SUPRACHIASMATIC NUCLEUS
1993 - 1993 下垂体、視床下部におけるホルモンによる転写活性変化の細胞単位での検索
1992 - 1993 Effect of thyroid hormone on gene expression in the central nervous system of newborn rats
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Papers (376)：
Taku James Sairenji, Shinnosuke Masuda, Yuya Higuchi, Mitsue Miyazaki, Hiroyuki Yajima, Oh Kwan Ee, Yuki Fujiwara, Takuya Araki, Noriaki Shimokawa, Noriyuki Koibuchi. Plasma prolactin axis shift from placental to pituitary origin in late prepartum mice. Endocrine journal. 2024
Hiraku Suzuki, Yuki Fujiwara, Winda Ariyani, Izuki Amano, Sumiyasu Ishii, Ayane Kate Ninomiya, Seiichi Sato, Akinori Takaoka, Noriyuki Koibuchi. 17β-Estradiol (E2) Activates Matrix Mineralization through Genomic/Nongenomic Pathways in MC3T3-E1 Cells. International Journal of Molecular Sciences. 2024
Ayane Ninomiya, Izuki Amano, Hiraku Suzuki, Yuki Fujiwara, Asahi Haijima, Noriyuki Koibuchi. Lactational exposure to perfluorooctane sulfonate remains a potential risk in brain function of middle-aged male mice. The journal of physiological sciences : JPS. 2024. 74. 1. 15-15
Michifumi Kokubo, Izuki Amano, Hiroyuki Yajima, Wataru Miyazaki, Yusuke Takatsuru, Asahi Haijima, Shogo Haraguchi, Noriyuki Koibuchi. Motor coordination is partially impaired in neonatal mice with moderate hypothyroidism but not with mild hypothyroidism. Thyroid Science. 2024. 1. 1. 100005-100005
Winda Ariyani, Noriyuki Koibuchi. The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives. Endocrine Journal. 2024
鈴木啓, 石井角保, 天野出月, 藤原悠基, 鯉淵典之, 佐藤精一. Construction of an experimental system in which estradiol increase matrix mineralization of the osteoblast-like cell line MC3T3-E1 and analysis of estrogen function in bone regulation. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
The latest technology for detection and management of neurodevelopment problems in community - Can we identify tissue damage/cancer just by taking blood sample?
(1st Sriwijaya International Conference on Medical Sciences 2018)
