Ueno Shinya

ウエノシンヤ | Ueno Shinya

Affiliation and department：
Job title： Professor
Other affiliations (1)：

弘前大学子どもの心の発達研究センター教授

Homepage URL (1)： http://www.med.hirosaki-u.ac.jp/~neurophysiol/

Research field (4)： Anesthesiology , Clinical pharmacy , Physiology , Neuroscience - general

Research keywords (12)： epilepsy , GABA-A receptor , anesthetics , ATP受容体 , pain , nicotinic , プリナージック受容体 , 神経因性疼痛 , パッチクランプ , purinergic receptor , neuropathic pain , patch-clamp

Research theme for competitive and other funds (35)：

2021 - 2026 Regulation of anesthetic efficacy through GABA-A R phosphorilation
2020 - 2023 神経発達障害の脆弱性と予測因子に関する研究
2018 - 2021 Study of regulatory system for anesthetic efficacy using GABA-A receptor plasticity
2017 - 2021 Investigation of mechanism of pathogenesis of postoperative and sepsis-associated delirium and cognitive dysfunction and development of the prophylaxis.
2016 - 2019 The effect of chronic benzodiazepine administration on cognitive function

2015 - 2018 The clarification of pathophysiology in Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder

2014 - 2017 The elucidation of the mechanism of activation in left side and right side of anterior cingulate cortex and the modulation of descending inhibitory pain pathway in chronic pain

2015 - 2017 Novel regulatory mechanism of anesthetic efficay by GABA-A receptor trafficking

2011 - 2014 A role of purinergic receptor on descending pain modulatory system in anterior cingulate cortex of chronic pain

2013 - 2014 Regulatory effects of GABA-A receptor trafficking and/or receptor phosphorylation on anesthetics

2011 - 2013 The pharmacological properties of tonic currents mediated by GABAA-Rs in BLA neurons

2010 - 2012 Regulation of the OHC cytoskeleton induced by lipid raft.-Effects of cholesterol alterations on hearing-

2011 - 2011 Research of novel regulatory mechanism of general anesthetics through receptor trafficking

2008 - 2010 Establishment of preventive strategies for nocturnal frontal lobe epilepsy-Elucidation of molecular mechanism to inhibit epileptic seizures

2008 - 2010 Anxiety is involved in tonic GABAergic inhibition in cerebral cortex and limbic system

2006 - 2009 Generation of epilepsy model animal bearing a genetic abnormality identified in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) of human

2006 - 2008 Direct functional analysis of prestin transfected inner ear using invivo patch method

2006 - 2008 Establishment of animal model harboring a homologous mutation ofhuman epilepsy and analysis of genomics"

2004 - 2008 てんかんの分子病態

2004 - 2008 Mollecular Mechanism of Epilepsy

2006 - 2007 分子病態を基本とした前頭葉てんかんに対する薬力学的個別化治療の開発

2006 - 2007 機能性精神疾患の皮質錐体細胞回路障害のtwo hit model仮説の構築

2006 - 2007 認知機能異常動物モデルを用いた慢性疼痛機構の解明

2005 - 2006 Elucidation of pathomechanisms in region-specific epileptogenesis of autosomal dominant nocturnal frontal lobe epilepsy

2005 - 2005 機能性精神疾患のtwo hiy model仮説の構築

2004 - 2005 神経因性疼痛の病態

2004 - 2005 Mechanism of Neuropathic Pain

2004 - 2005 Establishment of trigeminal neuralgia model and role of ATP receptor for neuropathic pain

2003 - 2005 Identification of the responsible genes for childhood epilepsies targeting at channels and receptors expressed in the brain

2002 - 2004 哺乳動物リバースジェネティクス法を用いたてんかんの候補遺伝子の同定

2002 - 2004 てんかん原性皮質形成異常におけるCl^-ホメオスタシスとGABA機能異常の分子機構

2000 - 2003 An approach for anti-sense therapy based on the establishment of an animal model for the epileptogenic cortical malformations

2001 - 2002 ATP-autocrine/paracrine release and its intracellular Ca^<2+> signals

1999 - 2002 Neuronal and behavioral research on the function of ATP receptors in the signal trasnduction of pain.

1999 - 2000 新規神経伝達物質としてのATPの慢性疼痛への関与とその分子機構に関する研究

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Papers (75)：

Ryo Kawabata, Shuji Shimoyama, Shinya Ueno, Ikuko Yao, Akiko Arata, Kohei Koga. TRPA1 as a O2 sensor detects microenvironmental hypoxia in the mice anterior cingulate cortex. Scientific reports. 2023. 13. 1. 2960-2960
Kenya Saruta, Tatsuhiro Fukutoku, Gentaro Kumagai, Toshihide Nagaoki, Manami Tsukuda, Yohshiro Nitobe, Kanichiro Wada, Toru Asari, Taku Fujita, Isamu Sasaki, et al. Intraperitoneal Administration of Etizolam Improves Locomotor Function in Mice After Spinal Cord Injury. Neurotrauma reports. 2023. 4. 1. 82-96
下山修司, 古川智範, 坂本由唯, 長谷川敦史, 清水律子, 小島宏建, 上野伸哉, 中村和彦. IGF-1を標的とした自閉スペクトラム症治療薬の探索. 日本脳科学会プログラム・抄録集. 2022. 49回. 35-35
藤井萌加, 下山修司, 古川智範, 上野伸哉. GABAA受容体の細胞内分布におけるβ3サブユニットのリン酸化の影響. 日本生理学雑誌. 2022. 84. 2. 35-35
増山望, 古川智範, 二階堂義和, 下山修司, 能登谷綾香, 上野伸哉. ジアゼパム長期使用による海馬神経機能への影響. 日本生理学雑誌. 2022. 84. 2. 36-36

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MISC (67)：

古川智範, 二階堂義和, 二階堂義和, 下山修司, 下山修司, 上野伸哉, 上野伸哉. 抗不安薬ジアゼパムの長期使用による海馬神経機能への影響. 日本脳科学会プログラム・講演抄録集. 2020. 47th
下山修司, 古川智範, 小潟佳輝, 中村和彦, 上野伸哉. 遺伝子Tspoの発現制御メカニズムの解明. 弘前医学. 2019. 69. 1-4. 207-207
二階堂義和, 二階堂義和, 古川智範, 下山修司, 櫛方哲也, 廣田和美, 上野伸哉, 上野伸哉. PRIP-1欠損マウスにおける静脈麻酔薬Propofolの麻酔効果の減弱. 弘前医学. 2018. 68. 2/4
古川智範, 二階堂義和, 下山修司, 三木康生, 古賀浩平, 中村和彦, 中村和彦, 若林孝一, 上野伸哉. ジアゼパム長期投与マウスにおける脳内Lcn2発現および認知機能の解析. 弘前医学. 2017. 68. 1. 88-88
二階堂義和, 古川智範, 下山修司, 古賀浩平, 上野伸哉. <一般演題抄録>うつ病モデルラットは内側前頭前野機能異常を起こす. 弘前医学. 2017. 67. 2. 185-185

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Books (1)：

カラー版ボロンブールペープ生理学
西村書店 2011 ISBN:4890134131

Education (2)：

- 1993 Tohoku University
- 1987 Kyushu Univ Faculty of Med

Professional career (1)：

医学博士 (東北大学)

Association Membership(s) (6)：

JAPAN BRAIN SCIENCE SOCIETY , Society for Neuroscience , 日本てんかん学会 , 日本神経科学学会 , 日本薬理学会 , 日本生理学会

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